A molecular component of the arterial baroreceptor mechanotransducer.
Neuron
; 21(6): 1435-41, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9883735
ABSTRACT
Baroreceptor nerve endings detect acute fluctuations in arterial pressure. We tested the hypothesis that members of the DEG/ENaC family of cation channels, which are responsible for touch sensation in Caenorhabditis elegans, may be components of the baroreceptor mechanosensor. We found the gamma subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus. A functional role for DEG/ENaC members was suggested by blockade of baroreceptor nerve activity and baroreflex control of blood pressure by an amiloride analog that inhibits DEG/ENaC channels. These data suggest that ENaC subunits may be components of the baroreceptor mechanotransducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension.
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Banco de datos:
MEDLINE
Asunto principal:
Presorreceptores
/
Presión Sanguínea
/
Canales de Sodio
/
Proteínas de Caenorhabditis elegans
/
Músculo Liso Vascular
/
Terminaciones Nerviosas
/
Ganglio Nudoso
Límite:
Animals
Idioma:
En
Revista:
Neuron
Asunto de la revista:
NEUROLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos