Amplification of BCR-ABL rearrangement in atypical Philadelphia chromosome: a new variant detected by fluorescence in situ hybridization in one case of acute lymphoblastic leukemia.
Cancer Genet Cytogenet
; 108(2): 158-61, 1999 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-9973946
ABSTRACT
We report on a 67-year-old woman with acute lymphoblastic leukemia (ALL) who was supposed to have a variant Philadelphia (Ph) translocation identified by conventional cytogenetic techniques. Fluorescence in situ hybridization (FISH) analysis demonstrated the presence of an amplification of BCR-ABL rearrangement at locus 22q11. This is the first observation, to our knowledge, of a duplicated BCR-ABL chimeric gene within the derived chromosome 22 in ALL. Our observation supports the possibility of detecting a variant Ph chromosome at the single-cell level by FISH analysis.
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Banco de datos:
MEDLINE
Asunto principal:
Cromosoma Filadelfia
/
Reordenamiento Génico
/
Proteínas de Fusión bcr-abl
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia