American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
An. bras. dermatol
; 94(3): 355-357, May-June 2019. graf
Article
em En
| LILACS
| ID: biblio-1011111
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Leishmaniose Cutânea
/
Insuficiência Renal Crônica
/
Antimoniato de Meglumina
/
Antiprotozoários
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
An. bras. dermatol
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil