Blood coagulation abnormalities in multibacilary leprosy patients
s.l; s.n; 2018. 20 p. ilus, tab, graf.
Non-conventional
em En
| SES-SP, HANSEN, HANSENIASE, SESSP-ILSLPROD, SES-SP, SESSP-ILSLACERVO, SES-SP
| ID: biblio-1023805
Biblioteca responsável:
BR191.1
Localização: BR191.1; 9494/S
ABSTRACT
Hemostatic illnesses are frequently associated with acute and chronic infections. In the present work we demonstrated that leprosy patients developed hemostatic abnormalities, like the formation of an atypical lipid clot mass during sera harvesting, a phenomenon previously observed and never unraveled. We characterize the nature of the "leprosum clot", formed during a protrombotic state developed by some patients. During the proteomic analysis of the leprosum clot we discovered a set of potential serum biomarkers to leprosy reactional episodes diagnosis, which at this moment is based only in clinical features. Taking together, our data suggest that leprosy patients are suffering from a procoagulant status, being beneficiated by the introduction of routine coagulation tests during their treatment, which will aloud physicians to prevent some of the acute clinical symptoms related with superficial vein thrombosis such as cyanosis and tissue necrosis observed during severe cases of leprosy reactional episodes. (AU)
Texto completo:
1
Bases de dados:
CONASS
/
SES-SP
Assunto principal:
Pele
/
Espectrometria de Massas
/
Transtornos da Coagulação Sanguínea
/
Biomarcadores
/
Eletroforese em Gel Bidimensional
/
Hanseníase Virchowiana
/
Modelos Lineares
/
Proteômica
/
Eletroforese em Gel de Poliacrilamida
/
Eritema Nodoso
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Non-conventional