Sporothrix brasiliensis produces the highest levels of oxidative stress in a murine model among the species of the Sporothrix schenckii complex
Rev. Soc. Bras. Med. Trop
; 50(4): 554-557, July-Aug. 2017. graf
Article
em En
| LILACS
| ID: biblio-1041421
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
We compared indicators of oxidative stress in the tissue of mice infected with strains from Sporothrix schenckii complex.METHODS:
Mice were inoculated with Sporothrix brasiliensis, Sporothrix schenckii sensu stricto, Sporothrix globosa, Sporothrix mexicana or Sporothrix albicans. The activity of catalase and glutathione were accessed in the liver and spleen.RESULTS:
Animals infected with S. brasiliensis exhibited splenomegaly and significant decrease in catalase activity, and protein and non-protein thiol content compared to animals infected with the other species.CONCLUSIONS:
Sporothrix brasiliensis exhibits higher pathogenicity compared to other species of the Sporothrix schenckii complex by increasing oxidative stress in animal tissue.Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Baço
/
Esporotricose
/
Estresse Oxidativo
/
Fígado
Limite:
Animals
/
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil