Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C
Rev. Soc. Bras. Med. Trop
; 53: e20190210, 2020. tab
Article
em En
| LILACS
| ID: biblio-1057300
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Hepatitis C virus (HCV) infection is involved in the pathogenesis of autoimmune and rheumatic disorders. Although the human platelet antigens (HPA) polymorphism are associated with HCV persistence, they have not been investigated in rheumatological manifestations (RM). This study focused on verifying associations between allele and genotype HPA and RM in patients with chronic hepatitis C.METHODS:
Patients (159) with chronic hepatitis C of both genders were analyzed.RESULTS:
Women showed association between HPA-3 polymorphisms and RM.CONCLUSIONS:
An unprecedented strong association between rheumatological manifestations and HPA-3 polymorphism, possibly predisposing women to complications during the disease course, was observed.Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Polimorfismo Genético
/
Doenças Reumáticas
/
Antígenos de Plaquetas Humanas
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Hepatite C Crônica
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
/
Aged80
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil