Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world
Heart
; 104(7): 581-587, 2018. tab
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1063260
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
OBJECTIVE:
To evaluate the performance of the non-laboratory INTERHEART risk score (NL-IHRS) to predict incident cardiovascular disease (CVD) across seven major geographic regions of the world. The secondary objective was to evaluate the performance of the fasting cholesterol-based IHRS (FC-IHRS).METHODS:
Using measures of discrimination and calibration, we tested the performance of the NL-IHRS (n=100 475) and FC-IHRS (n=107 863) for predicting incident CVD in a community-based, prospective study across seven geographic regions South Asia, China, Southeast Asia, Middle East, Europe/North America, South America and Africa. CVD was defined as the composite of cardiovascular death, myocardial infarction, stroke, heart failure or coronary revascularisation.RESULTS:
Mean age of the study population was 50.53 (SD 9.79) years and mean follow-up was 4.89 (SD 2.24) years. The NL-IHRS had moderate to good discrimination for incident CVD across geographic regions (concordance statistic (C-statistic) ranging from 0.64 to 0.74), although recalibration was necessary in all regions, which improved its performance in the overall cohort (increase in C-statistic from 0.69 to 0.72, p<0.001). Regional recalibration was also necessary for the FC-IHRS, which also improved its overall discrimination (increase in C-statistic from 0.71 to 0.74, p<0.001). In 85 078 participants with complete data for both scores, discrimination was only modestly better with the FC-IHRS compared with the NL-IHRS (0.74 vs 0.73, p<0.001)...
Texto completo:
1
Bases de dados:
CONASS
/
SES-SP
Assunto principal:
Doenças Cardiovasculares
/
Risco
/
Previsões
Tipo de estudo:
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Heart
Ano de publicação:
2018
Tipo de documento:
Article