One-year outcome of small-vessel disease treated with sirolimus-eluting stents: a subgroup analysis of the e-SELECT registry
J Interven Cardiol
; 26: 163-172, 2013. tab, graf
Article
em En
| SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1063683
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
Objectives:
To investigate the characteristics and one-year outcomes following sirolimus-eluting CYPHER Select Plus stent (SES) implantation in small (SmVD) and non-small vessel disease (NSmVD) in the internationale-SELECT registry.Background:
Large-scale registry data are lacking on DES outcomes in SmVD treatment.Methods:
There were 4,700 SmVD (at least one vessel with estimated reference vessel diameter [RVD] < 2.5 mm, excluding 283 patients with unknown RVD vessels) and 10,139 NSmVD only patients.Results:
The SmVD population was older, with more women, diabetics, and vessels treated, higher mean CharlsonComorbidity Index score (CCI), shorter lesions, and less STEMI presentation. The 1-year stent thrombosis (ST) rate (primary end-point), was significantly higher (1.3% vs. 0.7%) in SmVD versus NSmVD, mainly driven by early events. One-year major adverse cardiac event (MACE), myocardial infarction (MI), and clinically indicated target-lesion revascularization (TLR) rates were significantly higher in SmVD although death and major bleeding rates were similar in both groups. Complication rates were similar between pure (3,188 patients; only RVD < 2.5 mm) and mixed (1,795 patients; some RVD < 2.5 mm or unknown RVD) SmVD. Multivariate predictors for 1-year MACE in SmVD included saphenous vein graft or bifurcation lesions, major bleeding, any antiplatelet therapy discontinuation within 1 month, age, number of stents implanted, CCI, acute coronary syndrome, and insulin-dependent diabetes mellitus.Conclusion:
SES implantation for SmVD occurs more frequently in women, diabetics, and those with multivesseldisease and comorbidities. One-year ST, MACE, MI, and clinically indicated TLR rates are higher, although low overall, in SmVD or mixed SmVD patients while death rates are similar to NSmVD.
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Bases de dados:
CONASS
/
SES-SP
Assunto principal:
Stents
/
Sirolimo
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Interven Cardiol
Ano de publicação:
2013
Tipo de documento:
Article