Photobiomodulation of matrix metalloproteinases in rat calcaneal tendons
Photobiomodul Photomed Laser Surg, v. 37, n. 7, p. 421-427, jul. 2019
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: bud-2790
Biblioteca responsável:
BR78.1
ABSTRACT
Objective:
The main objective was to verify the modulatory effects of MMP-1, MMP-3, and MMP-13 levels on the partially injured calcaneal tendons of rat exposure to photobiomodulation.Background:
Photobiomodulation has been shown to have anti-inflammatory and regenerative effects on tendon injuries. However, there is still uncertainty regarding the beneficial effects in matrix metalloproteinase (MMP) levels, especially MMP-1, -3, and -13. Materials andmethods:
Sixty-five male Wistar rats were used. Sixty were submitted to a direct trauma on the calcaneal tendons and were randomly distributed into the following six groups LASER 1, 3, and 7 (10 partially injured calcaneal tendons in each group treated with photobiomodulation for 1, 3, and 7 days, respectively) and Sham 1, 3, and 7 (same injury, with simulated photobiomodulation). The remaining five animals were allocated to the normal group (no injury or treatment procedure). The 780?nm low-level laser was applied with 70?mW of mean power and 17.5 J/cm2 of fluency for 10 sec, once a day. The tendons were surgically removed and analyzed for MMP-1, MMP-3, and MMP-13 through immunohistochemistry.Results:
MMP-3 levels remained close to normal in all experimental groups (p > 0.05); however, reductions (p < 0.05) in MMP-1 and MMP-13 levels were detected in the groups submitted to one, three, and seven low level laser therapy applications.Conclusions:
The photobiomodulation protocol was able to reduce MMP-1 and MMP-13 levels in injured calcaneal tendons.
Texto completo:
1
Bases de dados:
CONASS
/
SES-SP
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Photobiomodul Photomed Laser Surg
/
Photobiomodulation, Photomedicine, and Laser Surgery
Ano de publicação:
2019
Tipo de documento:
Article