Methylation status of LDLR, PCSK9 and LDLRAP1 is associated with cardiovascular events in familial hypercholesterolemia
Epigenomics, in press, 1-12, jun. 2024
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: bud-5429
Biblioteca responsável:
BR78.1
ABSTRACT
Aim:
Methylation of LDLR, PCSK9 and LDLRAP1 CpG sites was assessed in patients with familialhypercholesterolemia (FH).Methods:
DNA methylation of was analyzed by pyrosequencing in 131FH patients and 23 normolipidemic (NL) subjects.Results:
LDLR, PCSK9 and LDLRP1 methylationwas similar between FH patients positive (MD) and negative (non-MD) for pathogenic variantsin FH-related genes. LDLR and PCSK9 methylation was higher in MD and non-MD groups thanNL subjects (p < 0.05). LDLR, PCSK9 and LDLRAP1 methylation profiles were associated withclinical manifestations and cardiovascular events in FH patients (p < 0.05).Conclusion:
Differentialmethylation of LDLR, PCSK9 and LDLRAP1 is associated with hypercholesterolemia and cardiovascularevents. This methylation profile maybe useful as a biomarker and contribute to the management ofFH.
Texto completo:
1
Bases de dados:
CONASS
/
SES-SP
Idioma:
En
Revista:
Epigenomics
Ano de publicação:
2024
Tipo de documento:
Article