The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates
Mem. Inst. Oswaldo Cruz
; 107(3): 433-436, May 2012. tab
Article
em En
| LILACS
| ID: lil-624029
Biblioteca responsável:
BR1.1
ABSTRACT
The extensive use of azole antifungal agents has promoted the resistance of Candida spp to these drugs. Candida glabrata is a problematic yeast because it presents a high degree of primary or secondary resistance to fluconazole. In Brazil, C. glabrata has been less studied than other species. In this paper, we compared the activity of three major classes of antifungal agents (azoles, echinocandins and polyenes) against fluconazole-susceptible (FS) and fluconazole-resistant (FR) C. glabrata strains. Cross-resistance between fluconazole and voriconazole was remarkable. Among the antifungal agents, the echinocandins were the most effective against FS and FR C. glabrata and micafungin showed the lowest minimal inhibitory concentrations.
Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Pirimidinas
/
Triazóis
/
Fluconazol
/
Anfotericina B
/
Candida glabrata
/
Equinocandinas
/
Antifúngicos
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Brasil