Performance of POC-CCA® in diagnosis of schistosomiasis mansoni in individuals with low parasite burden
Rev. Soc. Bras. Med. Trop
; 49(3): 341-347, tab, graf
Article
em En
| LILACS
| ID: lil-785789
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Schistosomiasis, caused by Schistosoma mansoni, is a public health concern in Brazil. However, the most popular diagnostic method, the Kato-Katz technique, exhibits low sensitivity in low-endemicity areas. We aimed to compare the performance of an immunological assay, the point-of-care circulating cathodic antigen (POC-CCA®) test, with that of two parasitological techniques in a low-endemicity population.METHODS:
Our study included 141 individuals living in Estreito de Miralta, Minas Gerais, Brazil. Fecal samples were obtained from all participants and analyzed for schistosomiasis using two parasitological techniques the Kato-Katz technique and the saline gradient technique. Additionally, POC-CCA® strips were utilized for testing urine samples. The results obtained by the different techniques were compared.RESULTS:
Analysis of two or 24 slides using the Kato-Katz technique resulted in a positivity rate of 10.6% (15/141) or 19.1% (27/141), respectively. The saline gradient technique yielded a positivity rate of 17.0% (24/141). The prevalence according to both parasitological techniques was 24.1% (34/141). The POC-CCA® test yielded a positivity rate of 22.7% (32/141); however, the positivity rate was merely 2.1% if trace results were considered negative. The agreements observed between POC-CCA® and the parasitological techniques were good (Kappa indexes > 0.64). The POC-CCA® test was more sensitive than the two-slide Kato-Katz technique (p < 0.05) in detecting cases of S. mansoni infection when trace results were considered positive.CONCLUSIONS:
These findings reinforce the importance of using multiple diagnostic techniques in low-endemicity areas for effective control of disease.Palavras-chave
Texto completo:
1
Bases de dados:
LILACS
Assunto principal:
Schistosoma mansoni
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Esquistossomose mansoni
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Fezes
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Antígenos de Helmintos
Tipo de estudo:
Diagnostic_studies
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Risk_factors_studies
Limite:
Aged80
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Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Brasil