Implementation of an Alcohol Screening, Brief Intervention, and a Referral Program at a Community Level II Trauma Center.

BACKGROUND: Trauma is the leading cause of years of potential life lost in the United States. Alcohol and drug use is a significant contributing factor. In 2017, a Level II community trauma center was achieving less than 80% screening rate compliance utilizing blood alcohol level as a screening method for trauma patients. The purpose of this article is to evaluate the implementation of a screening, brief intervention, and a referral-to-treatment service program. METHODS: In 2018, the trauma program adopted structured interviews as a screening method for trauma patients. The injury prevention coordinator conducted structured interviews as a screening method for trauma patients who met inclusion criteria. High-risk patients were referred to the social worker, who conducted a brief evaluation with subsequent referral to treatment. RESULTS: One year after the implementation of a structured interview approach, 1,021 trauma patients met inclusion criteria for this retrospective evaluation. From 2017 to 2018, the program observed an 86% statistically significant increase in screening using the structured interview SBIRT program (p < .0001) compared with the prior alcohol-level screening approach. CONCLUSIONS: On the basis of these data, a structured interview screening method demonstrated a significant improvement in screening compliance rates.

Does the modelling of the pectus bar affect its stability? Rationale for using a short flat bar.

OBJECTIVES: Although the Nuss procedure for pectus excavatum is still associated with a non-negligible risk of postoperative bar displacement, the potential effects of the length and shape of the bar on its corrective ability and stability have not been sufficiently studied. The aim of this study was to determine how the modelling of the pectus bar affects its stability and whether an alternative configuration of the implant can improve clinical success. METHODS: Simulated implantation of bars with different shapes and sizes in a computational model was carried out. A 250 N sternal force was applied to the bars, and the resulting forces and moments on the fixation points were identified. Afterwards, a clinical trial was carried out in a group of patients with pectus excavatum, some of whom received long inverted U-shaped bars and some of whom received implants designed from the computational results. RESULTS: When U-shaped bars were tested, the sternal force generated unbalanced horizontal reaction forces (16 vs 61 N) and large reaction moments at the ends of the bar, conferring the tendency to slide and to rotate, respectively. No lateral or rotational destabilizing forces occurred in the case of a flat bar. Cosmetic outcomes, postoperative times and hospital stays were similar in both clinical groups. However, 2 cases (2/15) of bar flipping occurred in patients who received the conventional bar. CONCLUSIONS: The shape of the bar is a determinant of its stability. A flat, shorter pectus bar provides adequate correction of the deformity with less tendency for bar displacement in the repair of pectus excavatum.

El lactitol incrementa el glutation reducido y disminuye el óxido nítrico en ratas Sprague-Dawley / Lactitol increases reduced glutathione and decreases nitric oxide in Sprague Dawley rats

Existe un creciente uso de los alcohol-azúcares como el lactitol en la industria de los alimentos. El estrés oxidativo juega un papel importante en la génesis de patologías digestivas que van desde inflamación hasta cáncer. El propósito de este estudio fue determinar el efecto del lactitol sobre el malondialdehído (MDA), óxido nítrico (NO), glutation reducido (GSH), ácido ascórbico y ácido dehidroascórbico como marcadores del balance oxidación/antioxidación. Para ello se utilizaron 80 ratas macho Sprague-Dawley divididas en cuatro grupos , tres experimentales de 20 animales, a los cuales se les administró por sonda orogástrica, lactitol en dosis de 0,3; 1,0 y 5,0 g/Kg/día durante 12 semanas y un grupo control que recibió solución salina fisiológica por el mismo período de tiempo. El lactitol administrado en dosis de 0,3; 1,0 y 5,0 g/Kg/día produjo un incremento significativo (P<0,05) del GSH (326,5 ± 13,0 µg/ml; 328,5 ± 9,2 µg/ml y 398,2 ± 11,8 µg/ml) al ser comparado con sus respectivos valores basales (285,8 ± 4,0 µg/ml; 280,0 ± 6,2 µg/ml y 279,5 ± 9,1 µg/ml). El lactitol a dosis de 5 g/Kg/día produjo el más alto incremento de la concentración de GSH y al mismo tiempo provocó una disminución significativa del los niveles de NO (33,0 ± 1,2 µM) cuando se comparó con su concentración basal (46,2 ± 2,8 µM). No fueron observados cambios significativos sobre el resto de los marcadores del balance oxidación/antioxidación. Aunque el lactitol es un alcohol-azúcar que no se absorbe a nivel del tracto gastrointestinal, es posible que los productos finales obtenidos luego de su metabolismo por las bacterias intestinales, induzcan efectos sistémicos que pueden afectar el balance oxidación/antioxidación a favor de la antioxidación.

Sugar alcohols such as lactitol are increasingly being used in the food industry. Tissue oxidative stress is an important contributor to the genesis of inflammatory bowel disease and cancer. The purpose of this study was to determine the effect of lactitol on malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), dehydroascorbic and ascorbic acid as redox markers. Eighty Sprague Dawley rats were divided into four groups; three experimental groups which received lactitol through an oral catheter at doses of 0.3; 1.0; 5 g/kg/day and an experimental group to which saline solution was administered during 12 weeks. Lactitol at doses of 0.3; 1.0; 5 g/kg/day produced a significant increase (P<0.05) on GSH (326.5 ± 13.0 µg/ml; 328.5 ± 9.2 µg/ml y 398.29 ± 11.8 µg/ml respectively) when compared with their respective basal values (285.8 ± 4.0 µg/ml; 280.0 ± 6.2 µg/ml y 279.5 ± 9.1 µg/ml). Lactitol dose of 5g/kg/day produced the highest increase on GSH levels and at the same time elicited a significant decrease on NO levels (33.0 ± 1.2 µM) when compared with basal values (46.2 ± 2.8 µM). No significant changes were observed on the remaining redox markers. Although lactitol is a sugar alcohol that is not absorbed in the small bowel, it is possible that its metabolisms end products, under intestinal bacterial effects, alter the redox balance in favor of antioxidants.