RESUMEN
An 8-month-old female Saint Bernard dog was presented with gait abnormalities consistent with a left-lateralizing cervical myelopathy. Imaging revealed a large, irregular soft tissue and mineral mass at the level of C1 and C2. The lesion was successfully excised, and histopathology was performed, revealing evidence of both multiple cartilaginous exostoses and calcinosis circumscripta. To the authors' knowledge, this is the first report comparing features using magnetic resonance imaging, computed tomography, and radiography. Additionally, multiple cartilaginous exostoses have not previously been reported to occur in combination with calcinosis circumscripta.
Asunto(s)
Calcinosis/veterinaria , Enfermedades de los Perros/diagnóstico , Exostosis Múltiple Hereditaria/veterinaria , Animales , Calcinosis/diagnóstico , Calcinosis/diagnóstico por imagen , Calcinosis/patología , Enfermedades de los Perros/diagnóstico por imagen , Enfermedades de los Perros/patología , Perros , Exostosis Múltiple Hereditaria/diagnóstico , Exostosis Múltiple Hereditaria/diagnóstico por imagen , Exostosis Múltiple Hereditaria/patología , Femenino , Imagen por Resonancia Magnética/veterinaria , Radiografía/veterinaria , Tomografía Computarizada por Rayos X/veterinariaRESUMEN
In this study, neurological complications associated with spontaneously occurring feline diabetes were comprehensively evaluated. Physical and neurological examinations, electrophysiological assessment, and biochemical and histological analysis of nerve and muscle biopsy specimens were performed in 19 diabetic cats and referenced to similar data from 28 nondiabetic cats without evidence of neuropathy. Compared to nondiabetic cats, diabetic cats exhibited a range of functional, structural, and biochemical defects that, depending on severity, manifested as striking neurological dysfunction. A broad spectrum of clinical signs was apparent with the most notable and severe impairment being a plantigrade posture when standing or walking. A sensorimotor neuropathy, characterized by conduction deficits and increased F wave and cord dorsum potential latencies, was present in both pelvic and thoracic limbs and, except in the most severely affected animals, occurred with little or no electromyographic abnormality. As for nerve structural abnormalities, Schwann cell injury was prevalent and included myelin defects, such as splitting and ballooning, and demyelination, although axonal degeneration was noted in biopsies from severely affected cats. Evidence of polyol pathway activity consisted of marked increases in nerve fructose without appreciable sorbitol accumulation. The occurrence of diabetic neuropathy in the cat, a relatively large animal with a long life span and long nerves, provides unique opportunities to study the development and treatment of this debilitating complication.
Asunto(s)
Enfermedades de los Gatos/fisiopatología , Diabetes Mellitus/veterinaria , Conducción Nerviosa/fisiología , Animales , Enfermedades de los Gatos/patología , Gatos , Diabetes Mellitus/patología , Diabetes Mellitus/fisiopatología , Femenino , Masculino , Fibras Nerviosas/patología , Fibras Nerviosas/ultraestructura , Examen Neurológico/veterinaria , Células de Schwann/patología , Células de Schwann/ultraestructuraRESUMEN
The clinical work-up, diagnosis and follow-up of an 8-year-old, female-spayed Shih Tzu with diffuse, granulomatous meningoencephalomyelitis (GME)-causing visual deficits is reported. The use of cytosine arabinoside as an alternative treatment for GME is discussed.