[The results of a clinical study of the preparation hydrazine sulfate]. / Rezul'taty klinicheskogo izucheniia preparata gidrazinsul'fat.

The paper discusses results of a cooperative study of effectiveness of hydrazine sulfate therapy in 740 patients with primary advanced, recurrent and metastatic solid tumors and malignant lymphomas who had failed all other treatment modalities. Both objective response and symptomatic effect were assessed. Objective response was observed in neuroblastoma, recurrent desmoid, Hodgkin's disease, lung cancer, fibrosarcoma and other tumors. Since hydrazine sulfate provided relief of a wide spectrum of cancer symptoms, it may be recommended for patients with end-stage cancer.

[Nitrosomethylurea in the treatment of patients with disseminated cutaneous melanoma]. / Nitrozometilmochevina v lechenii bol'nykh disseminirovannoi melanomoi kozhi.

Thirty cases of disseminated skin melanoma were treated with nitrosomethylurea which was given in 2-3 week courses (10 mg/kg twice a week each) at 1-2 month intervals. Complete response with a recurrence-free period of 6 months to over 3 years was registered in 3 patients (10%). A decrease in tumor size by more than 50% within 5-12 months was secured in 6 patients (20%). The responders survived longer than those in whom the treatment had failed. Side-effects were moderate and reversible. Nitrosomethylurea should be widely used in treatment of skin melanoma.

[Combined chemotherapy of disseminated skin melanoma]. / Kombinirovannaia khimioterapiia disseminirovannoi melanomy kozhi.

The author's experience with nitrosomethylurea+prospidine treatment in 37 patients having disseminated melanoma is described. The mentioned scheme of the combination therapy is proved to be effective.