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1.
J Biol Regul Homeost Agents ; 34(4 Suppl. 3): 51-57. Congress of the Italian Orthopaedic Research Society, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33261256

RESUMEN

The aim of our study was to define if Arthroscopic Transosseous Rotator Cuff Techniques should have comparable results to those of the suture-anchors technique in a single row configuration. We reported the preliminary results of a consecutive population of 22 patients who underwent a rotator cuff treatment on the left and right sides for average medium-sized thickness tears with minimal fatty infiltration with the two different techniques: transosseous rotator cuff repair technique on one side and single row with suture-anchors on the other side, in different times. Subjective evaluation with DASH questionnaires, Constant Scores and Numerical Rating Scale (NRS) for pain evaluation, have been submitted pre and postoperatively after both operations. A statistical analysis was performed to assess the superiority of one technique and to compare pre and postoperative ROM data and clinical outcomes. A transosseous rotator cuff repair was performed in 7 patients on the dominant arm, while the other 15 patients had dominant arm cuff tear lesions repaired by using suture-anchors technique. At last follow-up a significant improvement, in shoulder pain and function, was referred at both sides. Also, DASH, Constant Scores and NRS for pain evaluation improved with both techniques, but no statistical difference was found between them. Arthroscopic transosseous rotator cuff repair technique shows comparable results to those of the suture-anchors technique in a single row configuration.


Asunto(s)
Lesiones del Manguito de los Rotadores , Manguito de los Rotadores , Artroscopía , Humanos , Manguito de los Rotadores/cirugía , Lesiones del Manguito de los Rotadores/cirugía , Anclas para Sutura , Técnicas de Sutura , Resultado del Tratamiento
2.
Biomed Res Int ; 2018: 8961805, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30105260

RESUMEN

BACKGROUND: Recurrent shoulder dislocations occur much more frequently in adolescents than in the older population but a clear explanation of this incidence does not exist. The aim of the present study was to define the age-related distribution of the elastic fibers (EFs) in the shoulder capsule's extracellular matrix as a factor influencing shoulder instability. MATERIALS AND METHODS: Biopsy specimens were obtained from the shoulder capsule of patients divided preoperatively into three groups: Group 1 consisted of 10 male patients undergoing surgery for unidirectional traumatic anterior instability (TUBS); Group 2 consisted of 10 male patients undergoing surgery for multidirectional instability (MDI); Group 3 represents the control, including 10 patients with no history of instability. In addition to the group as a whole, specific subgroups were analyzed separately on the basis of the age of subjects: > 22 or < to 22 years. All the samples were analyzed by histochemical (Weigert's resorcinol fuchsin and Verhoeff's iron hematoxylin), immunohistochemical (monoclonal antielastin antibody), and histomorphometric methods. RESULTS: Both the elastin density and the percentage of area covered by EFs were significantly higher in younger subjects (<22 years old). Furthermore, the elastin density and the percentage of area covered by EFs were significantly higher in specimens of group of patients affected by multidirectional shoulder instability in comparison to the other two groups. CONCLUSION: Data of the present study confirmed the presence of an age-related distribution of EFs in the human shoulder capsule. The greater amount of EFs observed in younger subjects and in unstable shoulders could play an important role in predisposing the joint to first dislocation and recurrence.


Asunto(s)
Tejido Elástico/patología , Inestabilidad de la Articulación/fisiopatología , Luxación del Hombro/fisiopatología , Adolescente , Adulto , Factores de Edad , Artroscopía , Humanos , Masculino , Proyectos Piloto , Recurrencia , Hombro , Articulación del Hombro , Adulto Joven
3.
Musculoskelet Surg ; 101(Suppl 2): 169-173, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28770511

RESUMEN

PURPOSE: We evaluate the ability of in-season competitive athletes to return to competition after an anterior shoulder instability treated conservatively with a new dynamic brace combined with a specific rehabilitation program. METHODS: Twenty soccer players affected by traumatic anterior shoulder dislocation have been enrolled in the "Footballer In Season Fast Rehab" project during 2 consecutive football seasons. We excluded patients affected by rotator cuff tears and the bony defect over 25%. All the players have been treated the day after the first dislocation with a new dynamic brace used until the end of the second month after the first glenohumeral dislocation combined with a specific rehab protocol. Athletes were evaluated for the time necessary to completely resume sport activities, to complete the season, and for the recurrence of dislocation. RESULTS: All the athletes enrolled in this study were able to come back on the ground in approximately 40 days after the dislocation except 2 of them. Only two athletes claimed a slight discomfort at the return to play. One athlete had a traumatic relapse of the instability, 50 days after the dislocation. Another athlete claimed to have had a subluxation during a training session 45 days after the dislocation. 90% of the athletes were able to end the season without any shoulder discomfort. CONCLUSIONS: The dynamic brace combined to the rehabilitation protocol represents the solution that allows a quick start of resumption of training while maintaining a stable pain-free shoulder. LEVEL OF EVIDENCE: Level 4.


Asunto(s)
Tirantes , Inmovilización/instrumentación , Luxación del Hombro/terapia , Fútbol/lesiones , Adulto , Traumatismos en Atletas/rehabilitación , Traumatismos en Atletas/terapia , Supervivencia sin Enfermedad , Diseño de Equipo , Humanos , Inestabilidad de la Articulación/rehabilitación , Inestabilidad de la Articulación/terapia , Masculino , Recurrencia , Luxación del Hombro/rehabilitación , Resultado del Tratamiento , Adulto Joven
4.
Orthop Traumatol Surg Res ; 102(8): 989-994, 2016 12.
Artículo en Inglés | MEDLINE | ID: mdl-27825707

RESUMEN

BACKGROUND: Large fractures of the anterior glenoid rim can result in persisting instability and osteoarthritis of the glenohumeral joint When this fracture is associated with a glenohumeral dislocation and proximal humerus fracture could be a concern. The goal of this paper was to evaluate the clinical and radiological outcomes and complications of reverse shoulder arthroplasty (RSA) and glenoid bone graft in cases with a significant anterior glenoid fracture associated with a proximal humerus fracture. HYPOTHESIS: RSA and step bone graft harvested from proximal humeral head could be a viable option in the treatment of this complex injury. DESIGN: Retrospective case series. MATERIAL AND METHODS: Twenty-six patients underwent RSA and glenoid bone graft in a single stage procedure were evaluated at an average 32 months postoperatively. There were 18 women and 8 men with a mean age of 68.5 years (range 63-75 years). Reverse shoulder arthroplasty with a contoured glenoid bone graft placed underneath the baseplate using humeral head autograft was utilized in all cases. Clinical outcomes were evaluated with range of motion, Constant score and self-reported subjective outcome rated as excellent, good, fair or poor. Radiographic evaluation was performed to evaluate for baseplate displacement or loosening, bone graft union, resorption or collapse. RESULTS: At final follow-up, average active elevation was 135° (range 110°-145°), abduction 122° (range 60°-160°), and external rotation 30° (range 0 to 45°). The mean Constant score was 68.2 (range 54-83). The clinical results were rated as excellent by 15 patients, good by 9, and fair by 2. Radiographic evaluation showed the disc of cancellous bone graft healed without any signs of graft resorption or migration in all 26 cases. No reoperation was performed on any patient in this series. DISCUSSION/CONCLUSION: RSA with glenoid bone grafting produces satisfactory short-term outcomes with acceptable complication rates for treatment of patients greater than 60 years old with proximal humerus fractures associated with an anterior glenoid rim fracture. Further studies are necessary to determine the extended viability of this procedure. LEVEL OF EVIDENCE: III.


Asunto(s)
Artroplastia de Reemplazo/métodos , Trasplante Óseo/métodos , Cabeza Humeral/trasplante , Fracturas Intraarticulares/cirugía , Escápula/cirugía , Luxación del Hombro/cirugía , Fracturas del Hombro/cirugía , Anciano , Femenino , Fracturas Óseas/complicaciones , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/cirugía , Humanos , Masculino , Persona de Mediana Edad , Radiografía , Rango del Movimiento Articular , Reoperación , Estudios Retrospectivos , Escápula/lesiones , Luxación del Hombro/complicaciones , Luxación del Hombro/diagnóstico por imagen , Fracturas del Hombro/complicaciones , Fracturas del Hombro/diagnóstico por imagen , Articulación del Hombro/cirugía , Trasplante Autólogo
5.
Musculoskelet Surg ; 99 Suppl 1: S25-30, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25957543

RESUMEN

BACKGROUND: The treatment of clavicle fractures has historically been nonoperative, but several studies have recently shown the merits of operative management for specific fractures patterns. We developed a novel technique utilizing a 6.5-mm cannulated screw for fixation of displaced midshaft clavicle fractures. MATERIALS AND METHODS: We present 15 consecutive patients treated with this technique between 2007 and 2012. All patients were male, and all 15 suffered a traumatic injury involving a fall directly onto the affected side. Mean time from injury to surgery was 12 days (range 3-24 days). Decision for surgery was based on the displacement and shortening of the fracture, either at least 20 mm of shortening or displacement with no bony apposition. After surgery, all patients were placed in an abduction brace for 6 weeks. No motion was allowed for the first 3 weeks, followed by passive shoulder motion below 90° of forward flexion under the supervision of a therapist for the next 3 weeks. RESULTS: All 15 patients progressed to union at an average of 5.7 months (range 3-12). Three patients had superficial wound infections. Hardware removal was performed in 6 of the 15 patients at an average of 12 months (range 5-24). All patients regained full range of motion and strength in comparison with contralateral extremity. CONCLUSION: This novel technique limits soft tissue stripping. It has the advantages of using an implant familiar to most orthopedists and available in most hospital settings. We believe this technique is ideally suited for transverse fractures patterns, less than 14 days old, in males greater than 180 cm with clavicles large enough to accommodate a 6.5-mm screw.


Asunto(s)
Tornillos Óseos , Clavícula/lesiones , Fijación Intramedular de Fracturas/métodos , Fracturas Óseas/cirugía , Adolescente , Adulto , Clavícula/diagnóstico por imagen , Fijación Intramedular de Fracturas/instrumentación , Curación de Fractura , Fracturas Óseas/diagnóstico por imagen , Fracturas Óseas/etiología , Humanos , Masculino , Radiografía , Tiempo de Tratamiento
6.
Musculoskelet Surg ; 99 Suppl 1: S31-5, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25957544

RESUMEN

PURPOSE: The goal of this study was to report the clinical effects of two different braces after rotator cuff repair. METHODS: Forty patients who underwent an arthroscopic rotator cuff repair were prospectively allocated in this study. Twenty patients were immobilized in 15° external rotation brace (ER Group), and twenty were immobilised in an internal rotation sling (IR Group). For all patients, four surveys were done: in the immediate pre-operative period (T0), at 1 month (T1), at 3 months (T2) and at 6 months after surgery (T3). Range of motion and pain were evaluated by an independent physician. Self-Assessment Scales [(University California Los Angeles Shoulder Rating Scale (UCLA), Disability of the Arm Shoulder and Hand (DASH), Visual Analog Scale (VAS), Simple Shoulder Test (SST) and Physician Assessment Scale (Constant)] were also administered. RESULTS: Abduction and ER2 (external rotation with arm in abduction) were significantly greater in the ER group at T1, T2 and T3, ER1 (external rotation with arm at side) was significantly greater in the ER group at T1 and T2, IR2 (internal rotation) was significantly greater in the ER group at T1, and FFL (forward flexion) was significantly greater in the ER group at T1. VAS was significantly lower in the ER group at T1 and T2 and T3. About the Self-Assessment Shoulder Scales after 3 and 6 months, no differences were found. SST showed a lesser functional limitation for the ER group at T3. CONCLUSIONS: Patients operated with isolated superior or posterosuperior rotator cuff tear immobilised with brace in 15° of ER position showed less pain and a better passive range of motion at short time after surgery.


Asunto(s)
Inmovilización/métodos , Lesiones del Manguito de los Rotadores/cirugía , Articulación del Hombro , Adulto , Anciano , Artroscopía , Tirantes , Femenino , Estudios de Seguimiento , Humanos , Inmovilización/instrumentación , Masculino , Persona de Mediana Edad , Dolor Postoperatorio/prevención & control , Cuidados Posoperatorios/instrumentación , Cuidados Posoperatorios/métodos , Estudios Prospectivos , Rotación , Factores de Tiempo , Resultado del Tratamiento
7.
Musculoskelet Surg ; 98 Suppl 1: 35-9, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24659194

RESUMEN

BACKGROUND: Late sequelae of septic arthritis of the glenohumeral joint are very rare and represent a potentially devastating condition that can result in irreversible changes at the level of joint and surrounding soft tissues. MATERIALS AND METHODS: Between January 2001 and December 2010, ten patients were treated at our institution for late sequelae of septic arthritis of the shoulder. There were eight men and two women with a mean age of 67.9 years (range 62-74 years). Eight of ten patients had previously received three or more intra-articular or subacromial injections. Surgical treatment consisted of open joint debridement, humeral head resection and implantation of an antibiotic spacer followed by a 6-8-week course of intravenous antibiotics. RESULTS: White blood cell count, C-reactive protein and erythrocyte sedimentation rate normalized between 6 and 8 weeks postoperatively in all patients. No recurrent infection was observed in any patient. Postoperatively, the mean Constant score was 37 (range 28-46) and mean DASH score was 54 (range 40-69), demonstrating a very limited function in these patients. There was a trend toward improved outcome scores in patients who underwent early surgical debridement. Five patients underwent delayed reconstruction with a reverse shoulder prosthesis, and at minimum 1-year follow-up, the mean Constant score was 56 (range 47-69) and mean DASH score was 33 (31-38). CONCLUSIONS: Antibiotic spacers are able to deliver antibiotics locally to the infected tissue while reducing the dead space and stabilizing the glenohumeral joint. An early, aggressive management of the infection is essential to maximize clinical outcomes and avoid either significant destruction or ankylosis of the shoulder joint.


Asunto(s)
Antibacterianos/administración & dosificación , Artritis Infecciosa/diagnóstico por imagen , Artritis Infecciosa/terapia , Desbridamiento , Imagen por Resonancia Magnética , Anciano , Artritis Infecciosa/microbiología , Desbridamiento/métodos , Femenino , Estudios de Seguimiento , Humanos , Inyecciones Intralesiones , Masculino , Persona de Mediana Edad , Rango del Movimiento Articular , Reoperación , Estudios Retrospectivos , Articulación del Hombro/cirugía , Resultado del Tratamiento
8.
J Fish Dis ; 37(3): 241-50, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-23634773

RESUMEN

Melanomacrophage centres (MMCs), located in different organs of non-mammalian vertebrates, play a role in the destruction, detoxification or recycling of endogenous and exogenous materials. Cytochrome P450 monoxygenase 1A (CYP1A) is involved in xenobiotics biotransformation, and its liver expression is considered as a biomarker for detecting exposure to environmental pollutants. Atlantic bluefin tuna (ABFT), Thunnus thynnus L., liver samples were collected from: wild animals caught in the eastern Atlantic; juveniles reared in the central Adriatic; juveniles reared in the northern Adriatic; adults reared in the western Mediterranean. The samples were processed for basic histology, histochemistry and for CYP1A immunodetection. An unexpected high density of MMCs, containing ferric iron and lipofuscin-ceroids, was detected in the juveniles sampled in the northern Adriatic Sea. These individuals showed also a strong anti-CYP1A immunopositivity in hepatocytes and in the epithelium of bile ducts. This study supports the utility of MMCs as biomarkers of fish 'health status' and gives concern for a potential contaminant accumulation in ABFT.


Asunto(s)
Biomarcadores/análisis , Enfermedades de los Peces/patología , Hepatopatías/veterinaria , Hígado/patología , Atún , Animales , Croacia , Enfermedades de los Peces/metabolismo , Hígado/metabolismo , Hepatopatías/metabolismo , Hepatopatías/patología , Masculino , Mar Mediterráneo
9.
Musculoskelet Surg ; 97 Suppl 1: 39-47, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23605080

RESUMEN

BACKGROUND: We evaluated the role of matrix metalloproteases (MMPs) and their inhibitors which are involved in extracellular matrix remodeling and degradation, in the pathogenesis of chronic rotator cuff tears. MATERIALS AND METHODS: Tendon samples were harvested from 13 patients who underwent arthroscopic repair of a rotator cuff tear. Supraspinatus biopsy specimens were harvested en bloc from the arthroscopically intact middle portion of the tendon more than 1 cm from the torn edge, from the lateral edge of the tear, and from the superior one third of the macroscopically intact subscapularis tendon used as control. Histological analysis and an evaluation of the activity of specific metalloproteases and the tissue inhibitors of metalloprotease (TIMP-1, TIMP-2) was done blindly by multiplex sandwich ELISA (Search-Light technology) in each specimen RESULTS: Histological evidence of tendinopathy was present in all patients with a tear of the rotator cuff, and not in the macroscopically intact subscapularis tendon. There was a significant increase in MMP 1, MMP 2, MMP 3 and in TIMP-1, TIMP-2 levels in all specimens examined, including the macroscopically intact portion of the supraspinatus tendon and in the control specimens CONCLUSIONS: The tissue in the ruptured area of the supraspinatus tendon undergoes marked rearrangement at molecular levels. This involves the activity of MMP 1, 2 and 3, and supports the critical role of MMPs in the tendon physiology. Seemingly intact parts of the injured supraspinatus tendon can present tendinopathic features, with altered cellular metabolism.


Asunto(s)
Metaloproteasas/metabolismo , Lesiones del Manguito de los Rotadores , Manguito de los Rotadores/enzimología , Inhibidor Tisular de Metaloproteinasa-1/metabolismo , Inhibidor Tisular de Metaloproteinasa-2/metabolismo , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Manguito de los Rotadores/anatomía & histología , Manguito de los Rotadores/patología
10.
J Bone Joint Surg Br ; 92(10): 1410-5, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20884980

RESUMEN

Total shoulder replacement is a successful procedure for degenerative or some inflammatory diseases of the shoulder. However, fixation of the glenoid seems to be the main weakness with a high rate of loosening. The results using all-polyethylene components have been better than those using metal-backed components. We describe our experience with 35 consecutive total shoulder replacements using a new metal-backed glenoid component with a mean follow-up of 75.4 months (48 to 154). Our implant differs from others because of its mechanism of fixation. It has a convex metal-backed bone interface and the main stabilising factor is a large hollow central peg. The patients were evaluated with standard radiographs and with the Constant Score, the Simple Shoulder Test and a visual analogue scale. All the scores improved and there was no loosening, no polyethylene-glenoid disassembly and no other implant-related complications. We conclude that a metal-backed glenoid component is a good option in total shoulder replacement with no worse results than of those using a cemented all-polyethylene prosthesis.


Asunto(s)
Artroplastia de Reemplazo/métodos , Prótesis Articulares , Articulación del Hombro/cirugía , Anciano , Artritis Reumatoide/cirugía , Artroplastia de Reemplazo/instrumentación , Cementación , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Osteoartritis/cirugía , Diseño de Prótesis , Radiografía , Articulación del Hombro/diagnóstico por imagen , Titanio , Resultado del Tratamiento
11.
J Gen Virol ; 89(Pt 8): 1978-1986, 2008 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-18632970

RESUMEN

Human metapneumovirus (HMPV) is a recently discovered pathogen that causes a significant proportion of respiratory infections in young infants, the elderly and immunocompromised patients. Very little is known regarding the cellular signalling elicited by this virus in airway epithelial cells, the target of HMPV infection. In this study, we investigated the role of the RNA helicases retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene-5 (MDA-5) as the main pattern recognition receptors (PRRs) involved in viral detection and subsequent expression of proinflammatory and antiviral genes. HMPV infection readily induced RIG-I and MDA-5 gene and protein expression in A549 cells, a type II-like alveolar epithelial cell line. Expression of dominant-negative (DN) RIG-I or downregulation of RIG-I gene expression using small interfering RNA (siRNA) significantly decreased HMPV-induced beta interferon (IFN-beta), interleukin (IL)-8 and RANTES gene transcription, by inhibiting viral-induced activation of nuclear factor (NF)-kappaB and interferon regulatory factor (IRF), leading to enhanced viral replication. On the other hand, MDA-5 did not seem to play a significant role in HMPV-induced cellular responses. Mitochondrial antiviral signalling protein (MAVS), an adaptor protein linking both RIG-I and MDA-5 to downstream activation of IRF-3 and NF-kappaB, was also necessary for HMPV-induced cellular signalling. Expression of a DN MAVS significantly reduced IFN-beta and chemokine gene transcription, by inhibiting NF-kappaB- and IRF-dependent gene transcription, in response to HMPV infection. Our results show that HMPV activates the RIG-I-MAVS signalling pathway in airway epithelial cells, leading to the expression of important proinflammatory and antiviral molecules involved in the innate immune response to viruses.


Asunto(s)
Células Epiteliales/virología , Regulación de la Expresión Génica , Metapneumovirus/patogenicidad , Alveolos Pulmonares/virología , Receptores de Ácido Retinoico/metabolismo , Transducción de Señal , Proteínas Adaptadoras Transductoras de Señales/genética , Proteínas Adaptadoras Transductoras de Señales/metabolismo , Animales , Línea Celular , Chlorocebus aethiops , ARN Helicasas DEAD-box/genética , ARN Helicasas DEAD-box/metabolismo , Células Epiteliales/metabolismo , Humanos , Helicasa Inducida por Interferón IFIH1 , Proteínas/genética , Proteínas/metabolismo , Alveolos Pulmonares/citología , Alveolos Pulmonares/metabolismo , Interferencia de ARN , ARN Interferente Pequeño/genética , ARN Interferente Pequeño/metabolismo , Receptores de Ácido Retinoico/genética , Células Vero
12.
Virology ; 374(1): 114-27, 2008 Apr 25.
Artículo en Inglés | MEDLINE | ID: mdl-18234263

RESUMEN

Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections in infants, elderly and immunocompromised patients. Little is known about the response to hMPV infection of airway epithelial cells, which play a pivotal role in initiating and shaping innate and adaptive immune responses. In this study, we analyzed the transcriptional profiles of airway epithelial cells infected with hMPV using high-density oligonucleotide microarrays. Of the 47,400 transcripts and variants represented on the Affimetrix GeneChip Human Genome HG-U133 plus 2 array, 1601 genes were significantly altered following hMPV infection. Altered genes were then assigned to functional categories and mapped to signaling pathways. Many up-regulated genes are involved in the initiation of pro-inflammatory and antiviral immune responses, including chemokines, cytokines, type I interferon and interferon-inducible proteins. Other important functional classes up-regulated by hMPV infection include cellular signaling, gene transcription and apoptosis. Notably, genes associated with antioxidant and membrane transport activity, several metabolic pathways and cell proliferation were down-regulated in response to hMPV infection. Real-time PCR and Western blot assays were used to confirm the expression of genes related to several of these functional groups. The overall result of this study provides novel information on host gene expression upon infection with hMPV and also serves as a foundation for future investigations of genes and pathways involved in the pathogenesis of this important viral infection. Furthermore, it can facilitate a comparative analysis of other paramyxoviral infections to determine the transcriptional changes that are conserved versus the one that are specific to individual pathogens.


Asunto(s)
Células Epiteliales/virología , Redes Reguladoras de Genes , Metapneumovirus/crecimiento & desarrollo , Western Blotting , Perfilación de la Expresión Génica , Interacciones Huésped-Patógeno , Humanos , Análisis de Secuencia por Matrices de Oligonucleótidos , Mucosa Respiratoria/virología , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Regulación hacia Arriba
13.
J Orthop Traumatol ; 9(2): 105-8, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19384625

RESUMEN

BACKGROUND: Although nonoperative treatment is considered the standard of care for the treatment of grade I and II acromioclavicular joint injuries, the treatment of grade III injuries is controversial. There are as many methods of nonoperative treatment as there are for operative stabilization. That is why we conducted a literature research to find out the best evidence regarding the treatment of acute grade III acromioclavicular dislocation. METHOD: The research was limited to RCTs, systematic review and meta-analysis in the most representative databases. Even if research identifies more than 600 articles, only five were included in the study because there were RCTs, and systematic reviews, but no meta-analysis articles were found. Moreover, no meta-analysis was performed because of differences of data published in the three RCTs (different type of surgical treatments and different outcome measures). RESULTS: From the literature evaluation, clinical results seem to be comparable between the operative and the conservative treatments, but complications are more evident in the surgery group. Since there is not a preponderance of positive papers showing the benefits of a surgical technique over conservative therapy, the nonoperative treatment is still considered a valid procedure in the grade III acromioclavicular separation. CONCLUSION: More prospective randomized studies using validated outcome measures are needed to identify the suitable operation techniques for the acute injuries.

14.
Virology ; 368(1): 91-101, 2007 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-17655903

RESUMEN

Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections (LRTIs) in infants, elderly and immunocompromised patients. In this study, we show that hMPV can infect in a similar manner epithelial cells representative of different tracts of the airways. hMPV-induced expression of chemokines IL-8 and RANTES in primary small alveolar epithelial cells (SAE) and in a human alveolar type II-like epithelial cell line (A549) was similar, suggesting that A549 cells can be used as a model to study lower airway epithelial cell responses to hMPV infection. A549 secreted a variety of CXC and CC chemokines, cytokines and type I interferons, following hMPV infection. hMPV was also a strong inducer of transcription factors belonging to nuclear factor (NF)-kappaB, interferon regulatory factors (IRFs) and signal transducers and activators of transcription (STATs) families, which are known to orchestrate the expression of inflammatory and immunomodulatory mediators.


Asunto(s)
Células Epiteliales/virología , Metapneumovirus/crecimiento & desarrollo , Metapneumovirus/inmunología , Mucosa Respiratoria/virología , Línea Celular , Quimiocinas/biosíntesis , Humanos , Factores Reguladores del Interferón/metabolismo , Factor 3 de Genes Estimulados por el Interferón/metabolismo , FN-kappa B/metabolismo
15.
J Shoulder Elbow Surg ; 16(3): 352-7, 2007.
Artículo en Inglés | MEDLINE | ID: mdl-17188909

RESUMEN

Between January 1996 and July 2003, 93 consecutive patients operated on with a diagnosis of olecranon fractures were identified from our trauma unit files. Fourteen transolecranon fracture-dislocations were found after a retrospective X-radiographic evaluation. Eight patients were women and six were men, with a mean age of 54 years. There were 4 noncomminuted olecranon fractures, treated with K-wires and single tension-band wiring. The remaining 10 fractures were complex fractures, treated in 3 cases with multiple K-wires and single tension-band wiring, in 2 by use of one-third tubular plates, in 1 with a 3.5-mm dynamic compression plate, and in the remaining 4 with 3.5-mm reconstruction plates. Ligament repair was not performed in any case. Three patients needed reoperation because of early failure of primary fixation. Patients were reviewed at a mean follow-up of 3.6 years. Two reported difficulties in daily activities, none with any symptoms of elbow instability. According to the Broberg and Morrey score, 4 patients had excellent results, 6 had good results, 2 had fair results, and 2 had poor results. Four patients showed signs of degenerative arthritis on the radiographs obtained at follow-up. We conclude that transolecranon fracture-dislocation is an underreported and misdiagnosed injury. Various fixation techniques can restore the anatomic relationships and contour of the trochlear notch; the imperative goal is to obtain a good stable primary fixation and allow early active mobilization.


Asunto(s)
Articulación del Codo/cirugía , Fijación Interna de Fracturas/métodos , Fracturas Óseas/cirugía , Rango del Movimiento Articular/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Curación de Fractura/fisiología , Fracturas Óseas/diagnóstico por imagen , Humanos , Luxaciones Articulares/diagnóstico por imagen , Luxaciones Articulares/cirugía , Masculino , Persona de Mediana Edad , Dolor Postoperatorio , Pronóstico , Radiografía , Recuperación de la Función , Estudios Retrospectivos , Medición de Riesgo , Lesiones de Codo
16.
Med Princ Pract ; 15(5): 382-6, 2006.
Artículo en Inglés | MEDLINE | ID: mdl-16888398

RESUMEN

OBJECTIVE: To present four cases of tuberculosis of the greater trochanter. CASE PRESENTATION AND INTERVENTION: The four cases (3 females and 1 male), aged 45-70 years, presented with mechanical pain in the trochanteric area associated with progressive swelling in the 3 female patients in whom mobility was also restricted. X-ray revealed a mass in 2 females; CT scan and MRI exhibited an abscess in the 3 females. Histological and bacteriological examinations showed Mycobacterium bovis in the 3 females and M. tuberculosis in the male. In the females, tritherapy and surgery were performed, while in the male quadritherapy and surgery. All the patients recovered and were followed up for 4-9 years. CONCLUSION: These cases show that both chemotherapy and surgery must be synergic if tuberculosis is diagnosed and an abscess is confirmed by imaging.


Asunto(s)
Fémur , Tuberculosis Osteoarticular/diagnóstico , Tuberculosis Osteoarticular/terapia , Anciano , Terapia Combinada , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Mycobacterium bovis/aislamiento & purificación , Mycobacterium tuberculosis/aislamiento & purificación , Tuberculosis Osteoarticular/microbiología
17.
Eur Spine J ; 15(6): 857-63, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15843970

RESUMEN

We report preliminary results for unstable sacral fractures treated with a modified posterior triangular osteosynthesis. Seven patients were admitted to our trauma center with an unstable sacral fracture. The average age was 31 years (22-41). There were four vertical shear lesions of the pelvis and three transverse fracture of the upper sacrum. The vertical shear injuries were initially treated with an anterior external fixator inserted at the time of admission. Definitive surgery was performed at a mean time of 9 days after trauma. The operation consisted in a posterior fixation combining a vertebropelvic distraction osteosynthesis with pedicle screws and a rod system, whereby the transverse fixation was obtained using a 6 mm rod as a cross-link between the two main rods. Late displacement of the posterior pelvis or fracture was measured on X-ray films according to the criteria of Henderson. The patients were followed-up for a minimum time of 12 months. Four patients who presented with a pre-operative perineal neurological impairment made a complete recovery. No iatrogenic nerve injury was reported. One case of deep infection was managed successfully with surgical debridement and local antibiotics. All patients complained of symptoms related to the prominence of the iliac screws. The metalwork was removed in all cases after healing of the fracture, at a mean time of 4.3 months after surgery. No loss of reduction of fracture was seen at final radiological follow-up. The preliminary results are promising. The fixation is sufficiently stable to allow an immediate progressive weight-bearing, and safe nursing care in polytrauma cases. The only problem seems to be related to prominent heads of the distal screws.


Asunto(s)
Fijación Interna de Fracturas/métodos , Sacro/lesiones , Sacro/cirugía , Fracturas de la Columna Vertebral/cirugía , Adulto , Tornillos Óseos , Femenino , Fijación Interna de Fracturas/instrumentación , Humanos , Masculino , Radiografía , Sacro/diagnóstico por imagen , Fracturas de la Columna Vertebral/diagnóstico por imagen
18.
Knee Surg Sports Traumatol Arthrosc ; 14(2): 193-7, 2006 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-15902415

RESUMEN

Chronic exertional compartment syndrome (CECS) of the leg is a pathological condition often related to overuse in subject who engage repetitive physical activities. Fascial release is the mainstay of surgical management. The purpose of this study was to evaluate the results obtained with a double incision decompressive fasciotomy. Eighteen consecutive athletes with a diagnosis of anterior and/or lateral CECS of the leg were operated on with a minimal double incision fascial release after a mean period of 4 months after onset of symptoms. In 11 cases (61%) CECS was bilateral. Surgery was performed without tourniquet and active mobilization was starting immediately. Sports activities were resumed gradually at a mean period of 25 days. The athletes were followed until 2 years. All resumed pre-injury level sports activity. Two patients (18%) of the 11 who underwent to bilateral fasciotomy referred a sensation of leg weakness for an average period of 3 months. The surgical technique presented in this paper seems to be a good mean to treat anterior and lateral leg CECS. The use of tourniquet is deconselled to obtain an accurate intraoperative haemostasis so reducing the risk of post-operative haematoma.


Asunto(s)
Síndromes Compartimentales/cirugía , Descompresión Quirúrgica/métodos , Fasciotomía , Pierna/cirugía , Deportes/fisiología , Adulto , Síndromes Compartimentales/fisiopatología , Femenino , Humanos , Pierna/fisiopatología , Masculino , Procedimientos Quirúrgicos Mínimamente Invasivos , Satisfacción del Paciente , Esfuerzo Físico/fisiología , Resultado del Tratamiento
19.
Knee Surg Sports Traumatol Arthrosc ; 14(6): 581-5, 2006 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-16374589

RESUMEN

Treatment of long head biceps (LHB) tendon pathology has become an area of renewed interest and debate among orthopaedic surgeons in recent years. The background of this manuscript is a description of biceps tenodesis which ensure continual dynamic action of the tendon which depresses the head and impedes lateral translation. A new technique has been developed in order to treat LHB tendon irreversible structural abnormalities associated with cuff rotator lesions. This technique entails the construction of a biological anchor between the LHB and supraspinatus and/or infraspinatus tendons according to arthroscopic findings. The rationale, although not supported by biomechanical studies is to obtain a triple, biomechanical effect. The first of these biomechanical effects which we try to promote through the procedure of transposition is the elimination of the deviation and oblique angle which occurs as the LHB completes its intra-articular course prior to reaching the bicipital groove. Furthermore, we have found this technique extremely useful in the presence of large ruptures of the rotator cuff with muscle retraction. The most common complication associated to this particular method, observed in less than 3%, is failed biological fixation which manifests as subsidence of the tenodesis and consequent descent of the tendon with evident aesthetic deformity.


Asunto(s)
Músculo Esquelético/cirugía , Articulación del Hombro/cirugía , Traumatismos de los Tendones/cirugía , Tendones/cirugía , Artroscopía , Fenómenos Biomecánicos , Humanos , Procedimientos Ortopédicos , Rango del Movimiento Articular , Manguito de los Rotadores/fisiopatología , Manguito de los Rotadores/cirugía , Lesiones del Manguito de los Rotadores , Síndrome de Abducción Dolorosa del Hombro/fisiopatología , Síndrome de Abducción Dolorosa del Hombro/cirugía , Articulación del Hombro/fisiopatología , Técnicas de Sutura , Traumatismos de los Tendones/fisiopatología
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