1.
Angew Chem Int Ed Engl
; 40(21): 4055-4060, 2001 Nov 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29712249
RESUMEN
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthesis, which exploits boron-mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.