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Multiple newly identified loci associated with prostate cancer susceptibility.

Eeles, Rosalind A; Kote-Jarai, Zsofia; Giles, Graham G; Olama, Ali Amin Al; Guy, Michelle; Jugurnauth, Sarah K; Mulholland, Shani; Leongamornlert, Daniel A; Edwards, Stephen M; Morrison, Jonathan; Field, Helen I; Southey, Melissa C; Severi, Gianluca; Donovan, Jenny L; Hamdy, Freddie C; Dearnaley, David P; Muir, Kenneth R; Smith, Charmaine; Bagnato, Melisa; Ardern-Jones, Audrey T; Hall, Amanda L; O'Brien, Lynne T; Gehr-Swain, Beatrice N; Wilkinson, Rosemary A; Cox, Angie; Lewis, Sarah; Brown, Paul M; Jhavar, Sameer G; Tymrakiewicz, Malgorzata; Lophatananon, Artitaya; Bryant, Sarah L; Horwich, Alan; Huddart, Robert A; Khoo, Vincent S; Parker, Christopher C; Woodhouse, Christopher J; Thompson, Alan; Christmas, Tim; Ogden, Chris; Fisher, Cyril; Jamieson, Charles; Cooper, Colin S; English, Dallas R; Hopper, John L; Neal, David E; Easton, Douglas F.

Nat Genet ; 40(3): 316-21, 2008 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-18264097

RESUMEN

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at

Asunto(s)

Predisposición Genética a la Enfermedad , Neoplasias de la Próstata/genética , Sitios de Carácter Cuantitativo , Adulto , Anciano , Anciano de 80 o más Años , Algoritmos , Australia , Estudios de Casos y Controles , Mapeo Cromosómico , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Polimorfismo de Nucleótido Simple , Reino Unido

RESUMEN

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