1.
J Org Chem
; 70(5): 1901-3, 2005 Mar 04.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15730318
RESUMEN
A short and highly efficient synthesis of (+)-biotin in 10 steps with 20% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.