RESUMEN
Phytochemical investigation of the endophytic fungus Coniothyrium sp. resulted in the isolation of a new phenoxyphenyl ether, named coniothyren (1), and two known compounds, coniol (2) and (+)-epoxydon (3). The structure of the new compound was elucidated by detailed spectroscopic analysis, namely, (1)H NMR, (13)C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Preliminary studies demonstrated that (+)-epoxydon (3) displayed good antibacterial and antialgal activities toward Bacillus megaterium and Chlorella fusca, respectively.
Asunto(s)
Antibacterianos/aislamiento & purificación , Ascomicetos/química , Éteres/aislamiento & purificación , Éteres Fenílicos/aislamiento & purificación , Antibacterianos/química , Antibacterianos/farmacología , Éteres/química , Éteres/farmacología , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Éteres Fenílicos/química , Éteres Fenílicos/farmacologíaRESUMEN
Cultivation of the marine-derived streptomycete isolate B8005 delivered three known antibiotics, resistomycin (1), resistoflavin (3a) and tetracenomycin (4), and a further member of the rare resistomycin class, the weakly antibiotically active 1-hydroxy-1-norresistomycin (2). From a related marine strain B4842, 1 and resistoflavin methyl ether (3b) have been isolated. The formation of 2 is of interest from a biosynthetic point of view.