RESUMEN
The authors present the case of a 71-year-old female patient who was operated on for 16 days of abdominal pain. The work points to malignant melanoma as a rare cause of abdominal pain and then shows the inscrutability of malignant melanoma and the importance of a multidisciplinary approach to this type of disease including subsequent dispensary by an oncologist. The emphasis on the prevention of this disease is an integral part of this approach.
Asunto(s)
Dolor Abdominal , Melanoma , Neoplasias Cutáneas , Humanos , Melanoma/secundario , Melanoma/complicaciones , Femenino , Anciano , Dolor Abdominal/etiología , Neoplasias Cutáneas/secundario , Neoplasias Cutáneas/patologíaRESUMEN
Authors present a case of a 58-year old pacient that underwent acute surgery for perforation of descending colon diverticulum by swallowed rabbit bone. The thesis focuses only on foreign bodies swallowed by adult patients. Comprehensive spectrum of foreign bodies that have entered the digestive tract in another way is omitted.
Asunto(s)
Divertículo del Colon , Cuerpos Extraños , Perforación Intestinal , Adulto , Animales , Divertículo del Colon/complicaciones , Divertículo del Colon/diagnóstico por imagen , Divertículo del Colon/cirugía , Cuerpos Extraños/complicaciones , Cuerpos Extraños/diagnóstico por imagen , Cuerpos Extraños/cirugía , Humanos , Perforación Intestinal/diagnóstico por imagen , Perforación Intestinal/etiología , Perforación Intestinal/cirugía , ConejosRESUMEN
Many unanswered questions remain in understanding the biosynthesis of the peptide hormone insulin. Here we elucidate new aspects in the mechanism of co-translational translocation initiation of pre-proinsulin in the endoplasmic reticulum. We utilize a translational arrest peptide derived from the x-box-binding protein (Xbp1) to induce ribosomal stalling and generate translocation intermediates. We find that the insulin signal sequence is rather weakly gating and requires the assistance of auxiliary translocon components to initiate translocation. Probing the translational intermediates with chemical crosslinking, we identified an early interaction with the translocon-associated protein (TRAP) complex. The TRAPß subunit interacts with pre-proinsulin before the peptide enters the Sec61 translocon channel in a signal sequence-dependent manner. We describe the substrate sequence determinants that are recognized by TRAP on the cytosolic site of the membrane to facilitate substrate-specific opening of the Sec61 translocon channel. Our findings support the hypothesis that the TRAP-dependence is in part determined by the content of glycine and proline residues mainly within the signal sequence.
Asunto(s)
Proteínas de Unión al Calcio/genética , Insulina/genética , Glicoproteínas de Membrana/genética , Precursores de Proteínas/genética , Transporte de Proteínas/genética , Receptores Citoplasmáticos y Nucleares/genética , Receptores de Péptidos/genética , Proteína 1 de Unión a la X-Box/genética , Retículo Endoplásmico/genética , Células HeLa , Humanos , Sustancias Macromoleculares/metabolismo , Sustancias Macromoleculares/ultraestructura , Proteínas de la Membrana/genética , Péptidos/genética , Modificación Traduccional de las Proteínas/genética , Señales de Clasificación de Proteína/genética , Proteómica , Ribosomas/genética , Canales de Translocación SEC/genéticaRESUMEN
The authors present two cases of intestinal invagination in adult patients. The first case is an 84-year-old polymorbid female patient indicated for acute surgical revision due to ileus with a finding of invagination in the sigmoid area, with no evidence of an organic cause. The second case, an 80-year-old polymorbid female patient, was indicated for acute surgical revision also due to ileus with a finding of invagination on the small intestine and with a proven neuroendocrine tumor. Unlike invagination in childhood where its cause is usually unknown[1,7], intestinal invagination is relatively rare in adults and it is mostly due to an organic cause, most frequently a benign tumor of the small intestine[2]. This study focuses on invagination as a rare cause of acute abdomen in adult patients.Key words: invagination - ileus - idiopathic.