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1.
Acta Clin Belg ; 79(3): 193-204, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38795066

RESUMEN

OBJECTIVES: Considering the high rates in the use of antibiotics for oral/dental conditions in older patients and the rise in antimicrobial resistance, appropriate antibiotic prescription is important. This narrative review aimed to discuss the challenges and special considerations when prescribing antibiotics to older patients for oral/dental conditions. METHODS: PubMed/MEDLINE, Scopus, Web of Science, and articles' reference lists were searched for antibiotics use for oral conditions by older patients. Moreover, scientific and professional organisations' official websites were searched for guidelines on antibiotic use in dentistry. RESULTS: Despite several guidelines about the use of antibiotics in dentistry, specific information on their administration to older patients is missing. Relevant challenges include age-related changes in pharmacokinetics and pharmacodynamics, comorbidities and polypharmacy associated with low adherence, contraindications, adverse reactions, and drug-drug interactions. In unfit and frail older patients some antibiotics should be avoided, or doses should be adjusted, according to medical conditions or medications received. Amoxicillin, with doses adapted to renal function, is one of the safest options, while other antibiotics should be chosen with caution upon indications and individual patient characteristics. CONCLUSIONS: Healthcare providers should prescribe antibiotics to unfit and frail older adults with caution, given the multitude of comorbidities and potential interactions with medications received. Further research is needed on the safe and effective use of antibiotics in older patients.


Asunto(s)
Antibacterianos , Humanos , Antibacterianos/administración & dosificación , Antibacterianos/uso terapéutico , Antibacterianos/farmacocinética , Anciano , Polifarmacia , Interacciones Farmacológicas , Enfermedades de la Boca/tratamiento farmacológico
2.
Aging Clin Exp Res ; 33(4): 1091-1100, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-31893384

RESUMEN

Pneumonia is one of the leading causes of morbidity and mortality from infection in elderly patients. The increased frequency of pneumonia among elderly subjects can be explained by the physiological changes linked to the progressive aging of the respiratory tree and the diminished immunological response. A spiral of event leads to frailty, infection and possible death; preventing pneumonia consists of controlling the risk factors. Dysphagia, which is associated with malnutrition and dehydration, is recognized as one of the major pathophysiological mechanism leading to pneumonia and its screening is crucial for the pneumonia risk assessment. The impairment in the oropharyngeal reflexes results in stagnation of foreign material in the lateral cavities of the pharynx which may then get aspirated repeatedly in the lungs and cause pneumonia. Pneumonia prevention starts with lifestyle modifications such as alcohol and tobacco cessation. A careful review of the risk-benefit of the prescribed medication is critical and adaptation may be required in elders with multiple morbidities. Respiratory physiotherapy and mobilization improve the functional status and hence may help reduce the risk of pneumonia. Maintaining teeth and masticatory efficiency is important if malnutrition and its consequences are to be avoided. Daily oral hygiene and regular professional removal of oral biofilm can prevent the onset of periodontitis and can avoid an oral environment favoring the colonization of respiratory pathogens than can then be aspirated into the lungs.


Asunto(s)
Trastornos de Deglución , Neumonía , Anciano , Envejecimiento , Humanos , Neumonía/prevención & control , Factores de Riesgo
3.
Clin Oral Investig ; 23(10): 3855-3863, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30685795

RESUMEN

OBJECTIVES: To assess in persons aged 70 years or older the microbiological alterations occurring around implants and natural teeth during and after 3 weeks of undisturbed plaque accumulation. Furthermore, to test the predictive value of several markers at baseline for the extent of inflammation around implants and teeth after this period. MATERIALS AND METHODS: Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored. Levels of six subgingival plaque microorganisms, the plaque index (PI), and the gingival index (GI) were assessed before (baseline), during (days 0, 7, 14, 21), and after plaque accumulation (days 28, 42). Six microorganisms; demographic and clinical variables at day 0 were further evaluated as potential predictors for presence of GI > 1 at days 21 and 28. RESULTS: The detection frequency of the selected bacteria did not differ between implants and teeth at any time point. Bacteria counts decreased in the preparatory phase and increased in the plaque accumulation phase. Patterns observed at implants and teeth were similar. Only Parvimonas micra at day 21 reached significantly higher counts at implants than teeth. For the prediction of clinical outcome at day 21, in the multivariable model, only implant vs. tooth was significant indicator for the primary outcome (p = 0.01). CONCLUSIONS: Overall, the analysis of subgingival/submucosal samples revealed only minor differences between implants and teeth during the development and resolution of inflammation. CLINICAL RELEVANCE: Within the limitations of our study, with plaque accumulation, elders develop more inflammation around implants than around teeth, in spite of similar bacterial profiles.


Asunto(s)
Implantes Dentales/microbiología , Placa Dental/microbiología , Gingivitis/microbiología , Mucositis/microbiología , Anciano , Índice de Placa Dental , Humanos , Índice Periodontal
4.
J Am Med Dir Assoc ; 19(12): 1039-1046, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-30471798

RESUMEN

Good oral health in old age is particularly important for maintaining adequate oral function, preventing pain and discomfort, controlling localized or systemic inflammation, sustaining social interaction, and preserving quality of life. Given that oral health is an integral part of general health and well-being, and that major chronic systemic and oral diseases share common risk factors, oral health prevention and promotion should be embedded within routine medical assessment and care provision. The role of medical physicians, particularly primary care physicians, geriatricians, and elderly care physicians, in community and long-term care facilities in assessing and promoting oral health in frail older adults is critical and has been emphasized in recent European recommendations. All physicians should appreciate the importance of oral health and incorporate an initial oral health screening into routine medical assessment and care. A short interview with patients and carers on current oral health practices may help to assess the risk for rapid oral health deterioration. The interview should be followed by an oral health assessment, using validated tools, for nondental health care providers. Based on these findings, the physician should decide on necessary follow-up procedures, which may include oral health counseling and/or dental referral. Oral health counseling should include advice on daily oral, mucosal, and denture hygiene; denture maintenance; dietary advice; smoking cessation; limitation of harmful alcohol consumption; management of xerostomia; and frequent dental review. To enable physicians to perform the tasks recommended in this publication, appropriate teaching at both undergraduate and postgraduate levels must be delivered in addition to provision of appropriate continuing education courses.


Asunto(s)
Cuidado Dental para Ancianos , Anciano Frágil , Promoción de la Salud , Enfermedades de la Boca/diagnóstico , Salud Bucal , Rol del Médico , Anciano , Consejo , Femenino , Humanos , Masculino , Enfermedades de la Boca/prevención & control , Medición de Riesgo
5.
Clin Oral Implants Res ; 29 Suppl 16: 351-358, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30328181

RESUMEN

OBJECTIVES: The aim of Working Group 4 was to address topics related to biologic risks and complications associated with implant dentistry. Focused questions on (a) diagnosis of peri-implantitis, (b) complications associated with implants in augmented sites, (c) outcomes following treatment of peri-implantitis, and (d) implant therapy in geriatric patients and/or patients with systemic diseases were addressed. MATERIALS AND METHODS: Four systematic reviews formed the basis for discussion in Group 4. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary. RESULTS: Bleeding on probing (BOP) alone is insufficient for the diagnosis of peri-implantitis. The positive predictive value of BOP alone for the diagnosis of peri-implantitis varies and is dependent on the prevalence of peri-implantitis within the population. For patients with implants in augmented sites, the prevalence of peri-implantitis and implant loss is low over the medium to long term. Peri-implantitis treatment protocols which include individualized supportive care result in high survival of implants after 5 years with about three-quarters of implants still present. Advanced age alone is not a contraindication for implant therapy. Implant placement in patients with cancer receiving high-dose antiresorptive therapy is contraindicated due to the associated high risk for complications. CONCLUSIONS: Diagnosis of peri-implantitis requires the presence of BOP as well as progressive bone loss. Prevalence of peri-implantitis for implants in augmented sites is low. Peri-implantitis treatment should be followed by individualized supportive care. Implant therapy for geriatric patients is not contraindicated; however, comorbidities and autonomy should be considered.


Asunto(s)
Implantes Dentales/efectos adversos , Fracaso de la Restauración Dental , Odontología , Periimplantitis/etiología , Cuidados Posteriores , Aumento de la Cresta Alveolar , Conservadores de la Densidad Ósea/efectos adversos , Consenso , Bases de Datos Factuales , Implantación Dental Endoósea , Susceptibilidad a Enfermedades , Humanos , Neoplasias/complicaciones , Periimplantitis/diagnóstico , Periimplantitis/epidemiología , Índice Periodontal , Prevalencia , Recurrencia , Factores de Riesgo
6.
Clin Oral Implants Res ; 29 Suppl 16: 311-330, 2018 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-30328186

RESUMEN

OBJECTIVES: his review evaluated implant survival in geriatric patients (≥75 years) and/or the impact of systemic medical conditions. MATERIALS AND METHODS: Systematic literature searches were performed to identify studies reporting on geriatric subjects with dental implants and on implant patients who had any of the seven most common systematic conditions among geriatric patients. Meta-analyses were performed on the postloading implant survival rates. The impact of systemic medical conditions and their respective treatment was qualitatively analyzed. RESULTS: A total of 6,893 studies were identified; of those, 60 studies were included. The fixed-effects model revealed an overall implant survival of 97.3% (95% CI: 94.3, 98.7; studies = 7) and 96.1% (95% CI: 87.3, 98.9; studies = 3), for 1 and 5 years, respectively. In patients with cardiovascular disease, implant survival may be similar or higher compared to healthy patients. High implant survival rates were reported for patients with Parkinson's disease or diabetes mellitus type II. In patients with cancer, implant survival is negatively affected, namely by radiotherapy. Patients with bone metastases receiving high-dose antiresorptive therapy (ART) carry a high risk for complications after implant surgery. Implant survival was reported to be high in patients receiving low-dose ART for treatment of osteoporosis. No evidence was found on implant survival in patients with dementia, respiratory diseases, liver cirrhosis, or osteoarthritis. CONCLUSIONS: Implant prostheses in geriatric subjects are a predictable treatment option with a very high rate of implant survival. The functional and psychosocial benefits of such intervention should outweigh the associated risks to common medical conditions.


Asunto(s)
Factores de Edad , Implantación Dental Endoósea , Implantes Dentales , Fracaso de la Restauración Dental , Anciano , Anciano de 80 o más Años , Pérdida de Hueso Alveolar , Conservadores de la Densidad Ósea/efectos adversos , Enfermedades Cardiovasculares/complicaciones , Demencia/complicaciones , Complicaciones de la Diabetes , Diabetes Mellitus Tipo 2/complicaciones , Humanos , Enfermedades Pulmonares/complicaciones , Metástasis de la Neoplasia , Neoplasias/complicaciones , Osteoporosis/complicaciones , Osteoporosis/terapia , Enfermedad de Parkinson/complicaciones , Radioterapia/efectos adversos , Factores de Riesgo , Análisis de Supervivencia , Xerostomía/complicaciones
7.
J Am Geriatr Soc ; 66(3): 609-613, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29266168

RESUMEN

This is an expert opinion paper on oral health policy recommendations for older adults in Europe, with particular focus on frail and care-dependent persons, that the European College of Gerodontology (ECG) and the European Geriatric Medicine Society (EUGMS) Task and Finish Group on Gerodontology has developed. Oral health in older adults is often poor. Common oral diseases such as caries, periodontal disease, denture-related conditions, hyposalivation, and oral pre- and cancerous conditions may lead to tooth loss, pain, local and systemic infection, impaired oral function, and poor quality of life. Although the majority of oral diseases can be prevented or treated, oral problems in older adults remain prevalent and largely underdiagnosed, because frail persons often do not receive routine dental care, due to a number of barriers and misconceptions. These hindrances include person-related issues, lack of professional support, and lack of effective oral health policies. Three major areas for action are identified: education for healthcare providers, health policy action plans, and citizen empowerment and involvement. A list of defined competencies in geriatric oral health for non-dental healthcare providers is suggested, as well as an oral health promotion and disease prevention protocol for residents in institutional settings. Oral health assessment should be incorporated into general health assessments, oral health care should be integrated into public healthcare coverage, and access to dental care should be ensured.


Asunto(s)
Cuidado Dental para Ancianos/normas , Caries Dental/prevención & control , Odontología Geriátrica/normas , Enfermedades Periodontales/prevención & control , Odontología Preventiva/normas , Anciano , Europa (Continente) , Femenino , Geriatría/normas , Envejecimiento Saludable , Humanos , Masculino , Persona de Mediana Edad , Salud Bucal , Salud Pública , Sociedades Odontológicas/estadística & datos numéricos
8.
J Clin Periodontol ; 44(12): 1236-1244, 2017 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28703323

RESUMEN

AIM: Professional oral health care (POHC) prevents nursing home-acquired pneumonia (NHAP) and its related mortality. We assessed the cost-effectiveness of POHC versus no POHC (nPOHC) and the monetary value of eliminating uncertainty by future research. METHODS: A German public-private payer perspective was adopted. A Markov model was used, following long-term care residents from admission to death. Cost-effectiveness was estimated as Euro/disability-adjusted life year (DALY) using Monte Carlo microsimulations. Value-of-information analyses were performed. The willingness-to-pay threshold/DALY was assumed to be 66% (range 50%-100%) of per-capita gross domestic product (GDP). RESULTS: nPOHC was less costly (€3,024) but also less effective (0.89 DALYs) than POHC (€10,249, 0.55 DALYs). For most presumed payers, POHC was cost-effective. The cost-effectiveness of POHC was higher in smokers, underweight or pulmonary disease patients. Eliminating uncertainty about the NHAP costs, NHAP incidence/mortality, and POHC effectiveness would result in an expected net value of 47 million €/year (and even higher values at lower GDP thresholds), and is likely to decrease with time. CONCLUSIONS: Within the chosen setting and on the basis of current evidence, POHC was cost-effective. Given the detected uncertainty, further research seems warranted.


Asunto(s)
Análisis Costo-Beneficio , Atención a la Salud , Casas de Salud , Salud Bucal , Neumonía/enfermería , Costos y Análisis de Costo , Alemania , Humanos , Enfermedades Pulmonares , Cadenas de Markov , Método de Montecarlo , Casas de Salud/economía , Salud Bucal/economía , Higiene Bucal , Neumonía/mortalidad , Fumadores , Delgadez , Incertidumbre
9.
Periodontol 2000 ; 73(1): 228-240, 2017 02.
Artículo en Inglés | MEDLINE | ID: mdl-28000268

RESUMEN

In the developed world, the large birth cohorts of the so-called baby boomer generation have arrived in medical and dental practices. Often, elderly patients are 'young-old' baby boomers in whom partial edentulism is the predominant indication for implant therapy. However, the generation 85+ years of age represents a new challenge for the dental profession, as their lives are frequently dominated by dependency, multimorbidity and frailty. In geriatric implant dentistry, treatment planning is highly individualized, as interindividual differences become more pronounced with age. Nevertheless, there are four typical indications for implant therapy: (i) avoidance of removable partial prostheses; (ii) preservation of existing removable partial prostheses; (iii) stabilization of Kennedy Class I removable partial prostheses; and (iv) stabilization of complete prostheses. From a surgical point of view, two very important aspects must be considered when planning implant surgery in elderly patients: first, the consistent strive to minimize morbidity; and, second, the fact that coexisting medical risk factors are significantly more common in elderly patients. Modern three-dimensional cone beam computed tomography imaging is often indicated in order to plan minimally invasive implant surgery. Computer-assisted implant surgery might allow flapless implant surgery, which offers a low level of postoperative morbidity and a minimal risk of postsurgical bleeding. Short and reduced-diameter implants are now utilized much more often than a decade ago. Two-stage surgical procedures should be avoided in elderly patients. Implant restorations for elderly patients should be designed so that they can be modified to become low-maintenance prostheses, or even be removed, as a strategy to facilitate oral hygiene and comfort in the final stage of life.


Asunto(s)
Cuidado Dental para Ancianos , Implantación Dental Endoósea/métodos , Implantes Dentales , Anciano , Anciano de 80 o más Años , Diseño de Prótesis Dental , Humanos
10.
Clin Oral Implants Res ; 28(8): 1005-1012, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-27333829

RESUMEN

OBJECTIVES: To compare in persons aged 70 years or older the clinical and inflammatory changes occurring around implants and natural teeth during and after a phase of undisturbed plaque accumulation. MATERIAL AND METHODS: Twenty partially edentulous participants with titanium implants refrained from oral hygiene practices while being clinically monitored in weekly intervals for 21 days. Teeth and implants were then cleaned, oral hygiene resumed, and the participants were further monitored for 3 weeks. Twelve biomarkers were assessed in gingival and peri-implant crevicular fluid (GCF, PCF). RESULTS: During 3 weeks of oral hygiene abstention, the gingival index (GI) continuously increased. On day 21, there were significantly more sites with GI >1 at implants than at teeth. After restarting oral hygiene, the GI decreased markedly in both groups. Throughout the experiment, the plaque index was significantly higher on teeth than on implants. The different biomarkers reacted variably. IL-1ß increased significantly with plaque accumulation. IL-1ß, GM-CSF, TNF-α, and IFN-γ were significantly higher in GCF compared to PCF at day 21. IL-8 decreased significantly in GCF up to day 14. MIP-1ß decreased significantly in GCF, but not in PCF. At the 3-week follow-up, the levels of all biomarkers assessed in GCF and PCF had returned to baseline values. CONCLUSIONS: In an elderly cohort, plaque accumulation induced an inflammatory reaction around both teeth and implants. Although there was less plaque accumulation on implants, the peri-implant mucosa showed a stronger clinical response than gingiva.


Asunto(s)
Gingivitis/patología , Estomatitis/patología , Anciano , Anciano de 80 o más Años , Biomarcadores/análisis , Quimiocina CCL4/análisis , Implantes Dentales/efectos adversos , Placa Dental/patología , Femenino , Líquido del Surco Gingival/química , Gingivitis/etiología , Factor Estimulante de Colonias de Granulocitos y Macrófagos/análisis , Humanos , Interleucina-1beta/análisis , Interleucina-8/análisis , Masculino , Índice Periodontal , Estomatitis/etiología , Factor de Necrosis Tumoral alfa/análisis
11.
Clin Oral Implants Res ; 28(8): 920-930, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-27273468

RESUMEN

OBJECTIVE: This systematic review was conducted to evaluate the outcome of dental implant therapy in elderly patients (≥65 years). MATERIAL AND METHODS: Online database and hand searches were systematically performed to identify studies reporting on dental implants placed in the partially/completely edentulous jaws of elderly patients. Only prospective studies reporting on regular-diameter (≥3 mm), micro-rough surface implants were included in this review. Two investigators performed the search and data extraction. An inter-investigator reliability was verified using kappa statistics (κ). A meta-analysis was performed on implant survival rates, while the mean peri-implant marginal bone level changes (PI-MBL), technical/mechanical complications, and biological complications were reported descriptively. RESULTS: The systematic search yielded 2221 publications, of which 11 studies were included for statistical analyses. The calculated κ for the various parameters extracted was κ = 0.818-1.000. A meta-analysis was performed on the post-loading implant survival rates at 1, 3, 5, and 10 years. The random-effects model revealed an overall 1-year implant survival of 97.7% (95% CI: 95.8, 98.8; I2  = 0.00%, P = 0.968; n = 11 studies). The model further revealed an overall implant survival of 96.3% (95% CI: 92.8, 98.1; I2  = 0.00%, P = 0.618; n = 6 studies), 96.2% (95% CI: 93.0, 97.9; I2  = 0.00%, P = 0.850; n = 7 studies), and 91.2% (95% CI: 83.4, 95.6; I2  = 0.00%, P = 0.381; n = 3 studies) for 3, 5, and 10 years, respectively. The reported 1-year average PI-MBL ranged between 0.1 and 0.3 mm, while the reported 5- and 10-year PI-MBL were 0.7 and 1.5 mm, respectively. Information obtained pertaining to the technical and biological complications in the included studies was inadequate for statistical analysis. The frequent technical/mechanical complications reported were abutment screw loosening, fracture of the overdenture prostheses, activation of retentive clips, ceramic chipping, and fractures. The common biological complication reported included peri-implant mucositis, mucosal enlargement, bone loss, pain, and implant loss. CONCLUSIONS: This review provides robust evidence favoring dental implant therapy in elderly patients as a predictable long-term treatment option, in terms of implant survival, clinically acceptable PI-MBL changes, and minimal complications. Therefore, age alone should not be a limiting factor for dental implant therapy.


Asunto(s)
Implantes Dentales , Factores de Edad , Anciano , Implantación Dental , Fracaso de la Restauración Dental , Humanos , Arcada Edéntula/cirugía , Resultado del Tratamiento
12.
J Med Case Rep ; 7: 251, 2013 Nov 07.
Artículo en Inglés | MEDLINE | ID: mdl-24200238

RESUMEN

INTRODUCTION: While paraneoplastic syndromes in patients with malignant and metastasizing tumors are common, they are rarely associated with skin tumors showing predominantly local growth patterns. This case report relates to a patient with giant condyloma acuminatum, also called Buschke-Löwenstein tumor, with paraneoplastic hypercalcemia, who was successfully treated with conservative treatment. CASE PRESENTATION: The patient in question is a 48-year-old German man with a giant periscrotal tumor. Before and during the therapy, two episodes of symptomatic hypercalcemia occurred, which were successfully treated by bisphosphonates, intravenous fluids and diuretics. No evidence of lytic bone affection was found. CONCLUSIONS: Paraneoplastic hypercalcemia may occur in patients who have a Buschke-Löwenstein tumor. For patients, where surgery is not an option, established medical therapies like bisphosphonates may be useful in addition to diuretics and infusions.

13.
J Med Case Rep ; 6: 211, 2012 Jul 19.
Artículo en Inglés | MEDLINE | ID: mdl-22812671

RESUMEN

INTRODUCTION: Lung cancers are characterized by high incidence, prevalence and mortality. They may be associated with numerous paraneoplastic syndromes. Mild leukocytosis is not rare. The case described here, however, is of a female patient with adenocarcinoma of the lung who developed extreme leukocytosis at over 140,000 cells/µL. Descriptions of such leukemic forms of lung cancer are few and far between in the literature. In our case, the complete hematological diagnostic investigation, which included cytological, immunocytological, cytogenetic, histological and molecular genetic tests of the bone marrow (mutation analyses of BCR-ABL and JAK2), was accompanied for the first time by a molecular genetic workup of the primary tumor for epidermal growth factor receptor and K-RAS gene mutations. CASE PRESENTATION: We present the medical case of a 51-year-old female Caucasian patient, who was diagnosed with a poorly differentiated stage IV (International Union Against Cancer staging) adenocarcinoma of the lung. While undergoing treatment, our patient developed extreme leukocytosis, for which, despite extensive diagnostic tests, no infection-related or hematological cause could be identified. The tumor proved to be highly resistant to treatment. Our patient died only five months after the initial diagnosis. CONCLUSION: A leukemoid course can most likely be interpreted as the paraneoplastic production of hematopoietic growth factors. Despite the absence of a verified primary hematological origin, this possibility should always be investigated in all patients in a comparable situation.

14.
Clin Implant Dent Relat Res ; 14(6): 896-904, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-21414131

RESUMEN

BACKGROUND: The use of endosseous dental implants has become common practice for the rehabilitation of edentulous patients, and a two-implant overdenture has been recommended as the standard of care. The use of small-diameter implants may extend treatment options and reduce the necessity for bone augmentation. However, the mechanical strength of titanium is limited, so titanium alloys with greater tensile and fatigue strength may be preferable. PURPOSE: This randomized, controlled, double-blind, multicenter study investigated in a split-mouth model whether small-diameter implants made from Titanium-13Zirconium alloy (TiZr, Roxolid™) perform at least as well as Titanium Grade IV implants. METHODS AND MATERIALS: Patients with an edentulous mandible received one TiZr and one Ti Grade IV small-diameter bone level implant (3.3 mm, SLActive®) in the interforaminal region. The site distribution was randomized and double-blinded. Outcome measures included change in radiological peri-implant bone level from surgery to 12 months post-insertion (primary), implant survival, success, soft tissue conditions, and safety (secondary). RESULTS: Of 91 treated patients, 87 were available for the 12-month follow-up. Peri-implant bone level change (-0.3 ± 0.5 mm vs -0.3 ± 0.6 mm), plaque, and sulcus bleeding indices were not significantly different between TiZr and Ti Grade IV implants. Implant survival rates were 98.9 percent and 97.8 percent, success rates were 96.6 percent and 94.4 percent, respectively. Nineteen minor and no serious adverse events were related to the study devices. CONCLUSION: This study confirms that TiZr small-diameter bone level implants provide at least the same outcomes after 12 months as Ti Grade IV bone level implants. The improved mechanical properties of TiZr implants may extend implant therapy to more challenging clinical situations.


Asunto(s)
Implantación Dental Endoósea/métodos , Implantes Dentales , Diseño de Prótesis Dental , Arcada Edéntula/rehabilitación , Anciano , Anciano de 80 o más Años , Método Doble Ciego , Femenino , Humanos , Masculino , Mandíbula , Persona de Mediana Edad , Titanio , Resultado del Tratamiento , Circonio
15.
Strahlenther Onkol ; 187(12): 826-30, 2011 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-22127359

RESUMEN

BACKGROUND: While the activity of tyrosine kinase inhibitors as the first line treatment for primary tumors in patients with stage IV non-small cell lung cancer and a positive EGF receptor mutation is well known, little data on the efficacy in controlling cerebral metastases are available. CASE REPORT AND RESULTS: A 43-year-old woman was diagnosed with non-small cell lung cancer with cerebral and hepatic metastases. Emergency radiation therapy was initiated at the time of diagnosis due to superior vena cava syndrome. However, after she failed to respond to this therapy and in light of a positive EGF receptor mutation, gefitinib was added at a dose of 250 mg/day while continuing radiation to the primary lesion and cervical lymph nodes. She showed a rapid clinical and radiologic response with complete remission of the cerebral metastases 6 weeks after starting gefitinib. No severe toxicity was observed. CONCLUSION: This case demonstrates that gefitinib can be given during radiation treatment without significant toxicity. Furthermore, complete remission of cerebral metastases can be achieved with tyrosine kinase inhibitor monotherapy.


Asunto(s)
Adenocarcinoma/secundario , Antineoplásicos/uso terapéutico , Neoplasias Encefálicas/secundario , Neoplasias Pulmonares/tratamiento farmacológico , Quinazolinas/uso terapéutico , Adenocarcinoma/patología , Adenocarcinoma/radioterapia , Adulto , Neoplasias Encefálicas/patología , Neoplasias Encefálicas/radioterapia , Irradiación Craneana , Resistencia a Antineoplásicos , Femenino , Gefitinib , Humanos , Neoplasias Hepáticas/tratamiento farmacológico , Neoplasias Hepáticas/patología , Neoplasias Hepáticas/secundario , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/radioterapia , Metástasis Linfática/patología , Metástasis Linfática/radioterapia , Imagen por Resonancia Magnética , Estadificación de Neoplasias , Dosificación Radioterapéutica , Planificación de la Radioterapia Asistida por Computador
16.
Int J Prosthodont ; 23(5): 418-20, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20859556

RESUMEN

This case report describes the effect of complete denture abstention and subsequent rehabilitation with mandibular implant-supported overdentures (IOD) on masseter muscle thickness (MMT) in a 97-year-old patient. MMT was measured bilaterally using an ultrasound scanner during 1 year of wearing a conventional denture, after 101 days of voluntary denture abstention, and 3, 6, and 12 months after delivery of the IOD. MMT decreased by 17% during denture abstention following repeated implant surgery, and returned to 100% during the 12 months with the mandibular IOD. This case suggests that muscle bulk may be related to denture function.


Asunto(s)
Prótesis Dental de Soporte Implantado , Prótesis de Recubrimiento , Arcada Edéntula/fisiopatología , Músculo Masetero/anatomía & histología , Músculo Masetero/fisiología , Anciano de 80 o más Años , Implantación Dental Endoósea , Humanos , Arcada Edéntula/complicaciones , Masculino , Mandíbula , Músculo Masetero/diagnóstico por imagen , Contracción Muscular , Atrofia Muscular/etiología , Recuperación de la Función , Ultrasonografía
17.
Schweiz Monatsschr Zahnmed ; 118(9): 851-62, 2008.
Artículo en Francés, Alemán | MEDLINE | ID: mdl-18846977

RESUMEN

Palliative medicine deals with patients in the final phase of their life. These terminally ill patients should receive a treatment which focuses on the prevention and relief of suffering by means of early identification and assessment and treatment of pain and other problems, physical, psychosocial and spiritual. The treatment should focus on the improvement of the Quality of Life (QoL) instead of straining curative treatment approaches. It should also deal with the needs of the families. In palliative medicine an interdisciplinary approach is inevitable and imperative. Although an oral care provider should be a member of the palliative care team this is not always the case in palliative care settings. The prevention of infections, treatment of xerostomia, mucositis and candidiasis as well as the removal of sore spots are some of the important aspects of palliative oral treatment. They can have an immediate positive impact on the patients OHRQoL and their comfort in general. The particular dental work profile requires a practitioner with empathy and professional experience.


Asunto(s)
Atención Odontológica , Estética Dental , Dolor Facial/terapia , Cuidados Paliativos , Calidad de Vida , Anciano , Anciano de 80 o más Años , Candidiasis Bucal/terapia , Relaciones Dentista-Paciente , Femenino , Humanos , Masculino , Competencia Mental/legislación & jurisprudencia , Mucositis , Higiene Bucal , Estomatitis Subprotética/terapia , Xerostomía/terapia
18.
Semin Immunopathol ; 30(3): 273-8, 2008 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-18592239

RESUMEN

Oxidative stress plays an important role in periodontal health and disease. The phagocyte nicotinamide adenine dinucleotide phosphate oxidase NOX2 is most likely one of the key sources of reactive oxygen species (ROS) in periodontal tissues. This review will discuss three clinical aspects of NOX2 function. We will first focus on oral pathology in NOX2 deficiency such as chronic granulomatous disease (CGD). CGD patients are thought to suffer from infections and sterile hyperinflammation in the oral cavity. Indeed, the periodontium appears to be the most common site of infection in CGD patients; however, as periodontitis is also common in the general population, it is not clear to which extent these infections can be attributed to the disease. Secondly, the role of oxidative stress in periodontal disease of diabetic patients will be reviewed. Diabetes is indeed a major risk factor to develop periodontal disease, and increased activity of leukocytes is commonly observed. Enhanced NOX2 activity is likely to be involved in the pathomechanism, but data remains somewhat preliminary. The strongest case for involvement of NOX2 in periodontal diseases is aggressive periodontitis. Increased ROS generation by leukocytes from patients with aggressive periodontitis has clearly been documented. This increased ROS generation is to be caused by two factors: (1) genetically enhanced ROS generation and (2) oral pathogens that enhance NOX function. NOX enzymes in the oral cavity have so far received little attention but are likely to be important players in this setting. New therapies could be derived from these new concepts.


Asunto(s)
NADPH Oxidasas/metabolismo , Enfermedades Periodontales/enzimología , Complicaciones de la Diabetes/enzimología , Enfermedad Granulomatosa Crónica/complicaciones , Humanos , Enfermedades Periodontales/etiología
19.
Gerodontology ; 25(2): 107-12, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18380782

RESUMEN

OBJECTIVES: Dental care plays an important role in the multidisciplinary approach, which is used in palliative and long-term care to address the complex needs of terminally ill patients. The aim of this study was to assess the utilisation of dental services in a University Hospital Palliative and Long-term Care Unit. MATERIAL AND METHOD: Over an observation period of 13 months, structured questionnaires were filled in after each dental appointment. The survey covered three main topics: the initiation and incentive from the dental consultation, particular difficulties because of the patient's health or the hospital's organisation as well as the accomplished treatment. RESULTS: Two hundred and seventy-five questionnaires from a total of 102 patients were available for analysis. The patients' median age was 83 years (SD 10.3, range 49-101 years), 63 were female, 39 male. A majority of first appointments were initiated by a physician (n = 49 of 102), mainly because of pain (n = 62 of 275). 10.5% of the appointments were cancelled on the same day. Only one-fifth of the patients were able to reach the practice on foot. Six used a walking stick and 54 relied on a wheelchair. Eighteen patients needed to be seen in their bed. The most frequently performed procedures were extractions and removal of denture sore spots (n = 67 of 275) followed by the manufacturing of new dentures (n = 38 of 275). In more than 17% of the appointments, no particular treatment was performed. CONCLUSION: The utilisation of dental services in terminally ill and severely compromised elderly patients shown justifies a dental service in a palliative care or geriatric hospital setting. The particular dental work profile requires a practitioner with empathy and professional experience.


Asunto(s)
Cuidado Dental para Ancianos/estadística & datos numéricos , Servicio Odontológico Hospitalario/estadística & datos numéricos , Hospitales Universitarios , Anciano , Anciano de 80 o más Años , Femenino , Accesibilidad a los Servicios de Salud , Humanos , Cuidados a Largo Plazo , Masculino , Persona de Mediana Edad , Motivación , Cuidados Paliativos , Encuestas y Cuestionarios , Suiza , Resultado del Tratamiento
20.
Int J Prosthodont ; 17(5): 512-7, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-15543906

RESUMEN

PURPOSE: The present study investigated the residual functional constraints as well as the psychosocial rehabilitation of tumor patients following prosthetic treatment with implant-supported dentures. MATERIALS AND METHODS: A clinical examination and semistructured interview were performed in 66 of 132 consecutive patients who underwent tumor resection and subsequent implant-supported restoration between 1985 and 1997. RESULTS: Functional and psychosocial constraints were improved by between 91% (general comfort) and 47% (social reintegration) of all cases, but these constraints were never fully compensated for. Restrictions in tongue mobility, loss of sensation, and radiotherapy-induced hyposalivation led to problems in chewing and swallowing, which were hardly improved by prosthetic rehabilitation. The best subjective assessments referred to appearance, followed by masticatory improvement and denture retention. CONCLUSION: Functional impairment cannot be fully compensated by implant-supported prosthodontic reconstructions, but such treatment contributes essentially to general well-being and relief of disease-related social restrictions.


Asunto(s)
Prótesis Dental de Soporte Implantado , Neoplasias Maxilomandibulares/rehabilitación , Neoplasias de la Boca/rehabilitación , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/rehabilitación , Carcinoma de Células Escamosas/cirugía , Deglución , Femenino , Humanos , Entrevistas como Asunto , Neoplasias Maxilomandibulares/cirugía , Masculino , Masticación , Persona de Mediana Edad , Neoplasias de la Boca/cirugía , Estudios Retrospectivos , Ajuste Social , Habla , Lengua/fisiopatología
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