Asunto(s)
Fracturas Óseas/terapia , Hueso Pisiforme/lesiones , Traumatismos de la Muñeca/terapia , Adulto , Fracturas Óseas/diagnóstico por imagen , Fuerza de la Mano , Humanos , Masculino , Hueso Pisiforme/diagnóstico por imagen , Rango del Movimiento Articular , Recuperación de la Función , Tomografía Computarizada por Rayos X , Traumatismos de la Muñeca/diagnóstico por imagenRESUMEN
Buprenorphine was administered as sublingual tablets to 70 patients suffering from chronic pain of malignant or non-malignant origin. Daily doses ranging from 0.4 mg to 3.2 mg were administered and good analgesia was reported by the majority of patients. The most common unwanted effects were drowsiness/sleepiness, nausea and/or vomiting and sweating which appeared to be dose related but the incidence of dizziness was not related to daily dose. The incidence of all these unwanted effects except drowsiness/sleepiness decreased after the first week's treatment. No buprenorphine related changes in vital signs or laboratory values were observed and no signs of tolerance or physical dependence were seen in the short term period after discontinuation of treatment. A significant positive correlation between buprenorphine plasma concentration and daily dose was observed but there was no correlation between plasma levels and pain relief.
Asunto(s)
Buprenorfina/administración & dosificación , Morfinanos/administración & dosificación , Dolor/tratamiento farmacológico , Administración Oral , Adulto , Anciano , Buprenorfina/metabolismo , Buprenorfina/uso terapéutico , Enfermedad Crónica , Estudios de Evaluación como Asunto , Femenino , Humanos , Cinética , Masculino , Persona de Mediana EdadRESUMEN
The use of analgesic drugs is only one part of a multidisciplinary approach which offers also other possible palliative procedures for pain therapy. Pain complaints are placed against the background of terminal illness. The use of analgesic drugs and their combinations is discussed, with a short reference to their mechanism of action. The way of adminstration may have some impact on the efficacy of the analgesic regimen. Side effects and concomitant medication are reviewed.