RESUMEN
A patient receiving haemodialysis for 15 years developed systemic amyloidosis of beta 2 microglobulin type. Noticeable deposits of amyloid were present in the myocardium, intervertebral discs, joint cartilages and tendons. Less conspicuous amounts were present in blood vessel walls in the lungs, liver, adrenal glands and brain, and within the stroma of the prostate, testis and kidney, often with foci of calcification.
Asunto(s)
Amiloidosis/patología , Microglobulina beta-2/análisis , Vasos Sanguíneos/metabolismo , Huesos/metabolismo , Cartílago Articular/metabolismo , Humanos , Técnicas para Inmunoenzimas , Disco Intervertebral/metabolismo , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , Miocardio/metabolismo , Diálisis RenalRESUMEN
A 35-year-old man who had been treated by hemodialysis for 15 years suffered from systemic amyloidosis. It was identified as a beta 2-microglobulin type according to immunohistochemistry. Extensive amyloid deposits were found in myocardium, cartilages of intervertebral discs and in carpal tunnel ligament. Less conspicuous deposits comprised blood vessels of lungs, liver, suprarenal glands, brain, and stroma of prostate gland, testicles, kidney, often combined with calcified foci.
Asunto(s)
Amiloidosis/patología , Microglobulina beta-2/análisis , Adulto , Amiloidosis/metabolismo , Humanos , MasculinoRESUMEN
A group of 2,576 autopsies of children of the age of 0 to 15 years (made between 1978 and 1987) comprised 14 congenital (neonatal) tumours (among 93 tumorous lesions). Teratomas were the most frequent congenital tumours followed by neuroblastomas (4 and 3 cases). Neuroblastomas grew from cervical and thoracoabdominal sympathicus and from the right adrenal medulla. The most frequent and most extent hematogenic dissemination concerned liver, microscopical examination found dissemination in various organs as well as a lymphatic spread to regional lymph nodes (in 2 cases). One case was characterized by an exclusive continual destructive growth in retroperitoneum and posterior mediastinum with 2 macroscopical secondaries in skeleton. Pathognomic differentiated structures were always found by light microscopy. Differential diagnosis of round cell tumours of infancy was discussed with a concise exposure of symptomatology and autoptic findings of neuroblastomas according to congenital cases from literature.
Asunto(s)
Neuroblastoma/congénito , Adolescente , Niño , Preescolar , Humanos , Lactante , Neuroblastoma/patologíaRESUMEN
The paper summarizes the latest knowledge of carcinoma in situ in testicular tissue. It discusses their morphological, cytogenetic and histochemical characteristic including diagnosis. It stresses the necessity of correct fixation of bioptic samples of the testes. It deals with the malignant character of the cells of carcinoma in situ and reported data supporting their invasive potencial. Further the paper shows the incidence of this finding in at-risk groups as well as clinical and pathological correlations.
Asunto(s)
Biopsia , Carcinoma in Situ/patología , Neoplasias Testiculares/patología , Testículo/patología , Humanos , Masculino , Factores de RiesgoRESUMEN
Gonads were studied from 11 phenotypical women with syndromes of abnormal sexual differentiation. The group comprised 4 cases of complete and 3 cases of uncomplete testicular feminization one masculine pseudohermaphrodite with mosaic 45,XO/46,XY and 3 cases of Swyer syndrome. Sertoli-cells-only tubules with some nodes of so called "tubular adenomas" were the prevailing finding. One classical seminoma and two carcinomas in situ were registered in dysgenetic gonads.
Asunto(s)
Trastornos del Desarrollo Sexual/patología , Ovario/patología , Testículo/patología , Femenino , Humanos , MasculinoRESUMEN
Carcinoma in situ of the testis is an abnormality of the seminiferous epithelium characterized by aneuploid cells with clear cytoplasm located along the tubular basement membrane or in the lumina of tubules. Morphological, cytogenetic, and histochemical features of this anomaly are presented. An adequate fixation of testicular tissue samples is necessary for correct diagnosis. The fact that approximately 50% of carcinoma in situ may develop into malignant germ cell tumours of the testis in 5 years and the investigations of the testicular tissue adjacent to these tumours support the malignant nature and invasive potential of testicular carcinoma in situ. The incidence of carcinoma in situ in persons at risk is reviewed.
Asunto(s)
Carcinoma in Situ/patología , Disgerminoma/patología , Epitelio Seminífero/patología , Neoplasias Testiculares/patología , Testículo/patología , Biopsia , Carcinoma in Situ/epidemiología , Carcinoma in Situ/genética , Aberraciones Cromosómicas , Trastornos de los Cromosomas , Cromosomas Humanos Par 12 , Disgerminoma/epidemiología , Disgerminoma/genética , Humanos , Incidencia , Masculino , Factores de Riesgo , Neoplasias Testiculares/epidemiología , Neoplasias Testiculares/genéticaRESUMEN
The development of frequent gonadal tumors in some syndromes of abnormal sexual differentiation is often preceded by carcinoma in situ. To detect possible early changes in chromosome number and/or structure associated with the carcinoma in situ, gonadal tissue was studied in one patient with the complete form of testicular feminization syndrome, two patients with the incomplete form of this syndrome, and one patient with Swyer's syndrome. In all patients aneuploidy with a bimodal distribution of chromosome numbers with the peaks at diploid and near-tetraploid values was shown. The possible specific chromosomal marker of gonadal tumors, isochromosome i(12p), has not been found. Its absence suggests that this marker might be associated with more advanced stages of long-term cancer development or it could be confined only to a subgroup of testicular tumors, as was proposed earlier. The hypothesis that the major source of hypotetraploid or near-triploid cells often found in many gonadal tumors might be endoreduplications with their subsequent chromosome loss is supported.
Asunto(s)
Síndrome de Resistencia Androgénica/genética , Aberraciones Cromosómicas , Cromosomas Humanos Par 12 , Disgenesia Gonadal 46 XY/genética , Disgenesia Gonadal/genética , Lesiones Precancerosas/genética , Neoplasias Testiculares/genética , Adolescente , Niño , Femenino , Humanos , Cariotipificación , Masculino , PloidiasAsunto(s)
Neoplasias de la Mama/patología , Tumor Filoide/patología , Anciano , Femenino , Humanos , MetaplasiaRESUMEN
Three cases of benign vaginal rhabdomyoma were examined by light and electron microscopy. Frequency, localization, genesis, nomenclature, and differential diagnosis of the rare tumour were discussed.
Asunto(s)
Rabdomioma/patología , Neoplasias Vaginales/patología , Adulto , Femenino , HumanosRESUMEN
Aneurysmatic bone cyst is rare in ribs; only 37 cases were found in literature up to 1984. In a group of 21 children suffering from aneurysmatic bone cyst only one 13 year-old girl had the lesion in sternal part of the 2nd rib.
Asunto(s)
Quistes Óseos/patología , Costillas/patología , Adolescente , Femenino , HumanosRESUMEN
A cyst of the spleen covered by flat simple epithelium with parts of squamous metaplasia was found in a biopsy of a 14-year old boy. Pathology, origin, and nomenclature of this type of cyst were discussed.