RESUMEN
In the available literature, there are single papers on the association of the values of external respiratory function and the EchoCG sings of pulmonary hypertension with the morphological parameters of pulmonary arterial branches in idiopathic pulmonary hypertension (IPH) and secondary pulmonary hypertension (SPH). The present investigation comprised a comprehensive study of life-time functional changes in the cardiopulmonary system and postmortem morphometric changes in the heart and pulmonary vessels in idiopathic pulmonary fibrosis (IPF)-induced SPH and IPH. The investigation has indicated that PPH and SPH are characterized by the same-type rearrangement of pulmonary arterial branches as intimal hyperplasia and medial hypertrophy; however, IPH, as compared with SPH, induces a more significant cor pulmonale. The magnitude of right and left ventricular dysfunction corresponds to the degree of pulmonary hypertension (PH) and cor pulmonale. In IPF, the decreases in tidal volumes and pulmonary diffusion capacity favor PH progression.
Asunto(s)
Vasos Coronarios/patología , Hipertensión Pulmonar/patología , Hipertensión Pulmonar/fisiopatología , Fibrosis Pulmonar Idiopática/complicaciones , Arteria Pulmonar/patología , Arteria Pulmonar/fisiopatología , Adolescente , Adulto , Diagnóstico Diferencial , Progresión de la Enfermedad , Femenino , Humanos , Hiperplasia/patología , Hipertensión Pulmonar/etiología , Hipertrofia/patología , Masculino , Persona de Mediana Edad , Enfermedad Cardiopulmonar/patología , Pruebas de Función Respiratoria , Estudios Retrospectivos , Volumen de Ventilación Pulmonar , Túnica Íntima/patología , Disfunción Ventricular/patología , Adulto JovenRESUMEN
Examination covered 213 workers of asbestos technical ware plant. Standard X-ray examination no pulmonary and pleural changes were revealed. External respiration studies demonstrated moderate ventilation disorders in half of the examinees: in hardware workshop workers--restrictive type disorders, in autofriction components workshop workers--obstructive type ones with hyperventilation. Lower diffusing lung capacity in one-third of the workers in one of two autofriction components workshops proves most likely distributive disorders. Moderately increased serum alveolar mucin 3EG5 in 20% of the examinees could be a predictive criterion of slow formation of chisotyle pulmonary fibrosis.
Asunto(s)
Asbestosis/sangre , Mucinas/sangre , Adulto , Asbestosis/fisiopatología , Biomarcadores/sangre , Progresión de la Enfermedad , Femenino , Humanos , Mediciones del Volumen Pulmonar , Masculino , Índice de Severidad de la EnfermedadRESUMEN
AIM: To study cardiorespiratory system in adult patients with mucoviscedosis. MATERIAL AND METHODS: External respiration function, echocardiographic and dopplercardiographic evidence were analysed for 22 patients with mucoviscedosis. RESULTS: 66.7% examinees had mixed pulmonary ventilation disorders, 46% were found to have low diffuse capacity of the lungs correlating in degree with ventilatory abnormalities. Dilated right heart and high systolic pressure in the pulmonary artery were registered in 14% patients with marked obstruction. Left ventricular systolic and diastolic defects occurred in 23%. CONCLUSION: Adult patients with mucoviscedosis have mixed disorders of pulmonary ventilation, high pressure in pulmonary circulation and developing pulmonary heart in patients with severe obstruction.