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1.
J Radiat Res ; 64(6): 911-925, 2023 Nov 21.
Artículo en Inglés | MEDLINE | ID: mdl-37816672

RESUMEN

Several staffing models are used to determine the required medical physics staffing, including radiotherapy technologists, of radiation oncology departments. However, since Japanese facilities tend to be smaller in scale than foreign ones, those models might not apply to Japan. Therefore, in this study, we surveyed workloads in Japan to estimate the optimal medical physics staffing in external beam radiotherapy. A total of 837 facilities were surveyed to collect information regarding radiotherapy techniques and medical physics specialists (RTMPs). The survey covered facility information, staffing, patient volume, equipment volume, workload and quality assurance (QA) status. Full-time equivalent (FTE) factors were estimated from the workload and compared with several models. Responses were received from 579 facilities (69.2%). The median annual patient volume was 369 at designated cancer care hospitals (DCCHs) and 252 across all facilities. In addition, the median FTE of RTMPs was 4.6 at DCCHs and 3.0 at all sites, and the average QA implementation rate for radiotherapy equipment was 69.4%. Furthermore, advanced treatment technologies have increased workloads, particularly in computed tomography simulations and treatment planning tasks. Compared to published models, larger facilities (over 500 annual patients) had a shortage of medical physics staff. In very small facilities (about 140 annual patients), the medical physics staffing requirement was estimated to be 0.5 FTE, implying that employing a full-time medical physicist would be inefficient. However, ensuring the quality of radiotherapy is an important issue, given the limited number of RTMPs. Our study provides insights into optimizing staffing and resource allocation in radiotherapy departments.


Asunto(s)
Neoplasias , Oncología por Radiación , Humanos , Carga de Trabajo , Japón , Encuestas y Cuestionarios , Neoplasias/radioterapia , Física
2.
Radiol Phys Technol ; 16(4): 431-442, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-37668931

RESUMEN

This study aimed to investigate the educational environment of radiotherapy technology and medical physics specialists (RTMP) in Japan. We conducted a nationwide questionnaire survey in radiotherapy institutions between June and August 2022. Participants were asked questions regarding the educational system, perspectives on updating RTMP's skills and qualifications, and perspectives on higher education for RTMP at radiotherapy institutions. The results were then analyzed in detail according to three factors: whether the hospital was designed for cancer care, whether it was a Japanese Society for Radiation Oncology (JASTRO)-accredited hospital, and whether it was an intensity-modulated radiation therapy charged hospital. Responses were obtained from 579 (69%) nationwide radiation therapy institutions. For non-qualified RTMP, 10% of the institutions had their own educational systems, only 17% of institutions provided on-the-job training, and 84% of institutions encouraged participation in educational lectures and workshops in academic societies. However, for qualified RTMP, 3.0% of institutions had their own educational systems, only 8.9% of the institutions provided on-the-job training, and 83% encouraged participation in academic conferences and workshops. Less than 1% of the facilities offered salary increases for certification, whereas 8.2% offered consideration for occupational promotion. Regarding the educational environment, JASTRO-accredited hospitals were better than general hospitals. Few institutions have their own educational systems for qualified and non-qualified RTMP, but they encourage them to attend educational seminars and conferences. It is desirable to provide systematic education and training by academic and professional organizations to maintain the skills of individuals.


Asunto(s)
Oncología por Radiación , Humanos , Japón , Física , Tecnología , Encuestas y Cuestionarios
3.
iScience ; 25(8): 104763, 2022 Aug 19.
Artículo en Inglés | MEDLINE | ID: mdl-35992079

RESUMEN

Radium is refocused from the viewpoint of an environmental pollutant and cancer therapy using alpha particles, where it mainly exists as a hydrated ion. We investigated the radium hydration structure and the dynamics of water molecules by extended X-ray absorption fine structure (EXAFS) spectroscopy and ab initio molecular dynamics (AIMD) simulation. The EXAFS experiment showed that the coordination number and average distance between radium ion and the oxygen atoms in the first hydration shell are 9.2 ± 1.9 and 2.87 ± 0.06 Å, respectively. They are consistent with those obtained from the AIMD simulations, 8.4 and 2.88 Å. The AIMD simulations also revealed that the water molecules in the first hydration shell of radium are less structured and more mobile than those of barium, which is an analogous element of radium. Our results indicate that radium can be more labile than barium in terms of interactions with water.

4.
Sci Rep ; 12(1): 9808, 2022 Jun 13.
Artículo en Inglés | MEDLINE | ID: mdl-35697713

RESUMEN

Predicting materials properties of nuclear fuel compounds is a challenging task in materials science. Their thermodynamical behaviors around and above the operational temperature are essential for the design of nuclear reactors. However, they are not easy to measure, because the target temperature range is too high to perform various standard experiments safely and accurately. Moreover, theoretical methods such as first-principles calculations also suffer from the computational limitations in calculating thermodynamical properties due to their high calculation-costs and complicated electronic structures stemming from f-orbital occupations of valence electrons in actinide elements. Here, we demonstrate, for the first time, machine-learning molecular-dynamics to theoretically explore high-temperature thermodynamical properties of a nuclear fuel material, thorium dioxide. The target compound satisfies first-principles calculation accuracy because f-electron occupation coincidentally diminishes and the scheme meets sampling sufficiency because it works at the computational cost of classical molecular-dynamics levels. We prepare a set of training data using first-principles molecular dynamics with small number of atoms, which cannot directly evaluate thermodynamical properties but captures essential atomistic dynamics at the high temperature range. Then, we construct a machine-learning molecular-dynamics potential and carry out large-scale molecular-dynamics calculations. Consequently, we successfully access two kinds of thermodynamic phase transitions, namely the melting and the anomalous [Formula: see text] transition induced by large diffusions of oxygen atoms. Furthermore, we quantitatively reproduce various experimental data in the best agreement manner by selecting a density functional scheme known as SCAN. Our results suggest that the present scale-up simulation-scheme using machine-learning techniques opens up a new pathway on theoretical studies of not only nuclear fuel compounds, but also a variety of similar materials that contain both heavy and light elements, like thorium dioxide.

5.
Artículo en Japonés | MEDLINE | ID: mdl-35314535

RESUMEN

PURPOSE: It is necessary to perform gantry quality assurance (QA) in high precision radiotherapy. However, the O-ring type linear accelerator (Halcyon) does not have a light field and laser as a reference of isocenter point. The aim of this study is to investigate the usefulness of a three-dimensional diode array detector for gantry angle QA, and an O-ring type linear accelerator. METHOD: The gantry angle and rotational center were verified using the ArcCHECK 3D diode array on the general linear accelerator (TrueBeam) as a reference and Halcyon. The gantry angles were measured at 0, 90, 180, and 270°. The accuracy of the gantry rotational center was evaluated using rotational irradiation in the clockwise and counterclockwise directions between 181° and 179°. RESULTS: The QA system with ArcCHECK was able to apply on the TrueBeam and Halcyon. As a result of the accuracy of the gantry angle, the maximum error of value calculated from ArcCHECK was 0.1° compared with the nominal gantry angle of Halcyon. As a result of the accuracy of the gantry rotation isocenter of Halcyon, the distance between the isocenter and the gantry rotation center was 0.45 mm and 0.41 mm in the clockwise and counterclockwise directions, respectively. CONCLUSION: The QA system with ArcCHECK was useful for the gantry angle and the rotation center accuracy on the Halcyon.


Asunto(s)
Aceleradores de Partículas , Radioterapia de Intensidad Modulada , Rotación
6.
Phys Med ; 77: 121-126, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32823211

RESUMEN

PURPOSE: This study performed the accurate measurements of beam profiles with a new rigid board, which was consistent with the supplied reference beam profiles (RBPs) for clinical Halcyon model. METHODS: Percentage depth doses (PDDs), lateral and diagonal dose profiles were measured and compared with RBPs. A water tank was set on the rigid board bridged Halcyon bore without sagging and source-to-surface distance was 90.0 cm. Field sizes were from 2.0 to 28.0 cm squares and depths of lateral and diagonal dose profiles were 1.3, 5.0, 10.0, and 20.0 cm. For the PDD, the depth of maximum dose (dmax), PDD value at depth of 10.0 cm (PDD10), and absolute dose difference (DD) between RBP and measured beam profiles (MBP) were evaluated. For lateral and diagonal dose profiles, DDs for the whole and divided areas (central, shoulder, and extended areas) defined by third derivative, and distance-to-agreement (DTA) in the penumbra area were evaluated. RESULTS: For PDDs, the differences of dmax and PDD10 and DD beyond the dmax were within 1.0 mm, 0.3%, and 1.0%, respectively. For lateral and diagonal dose profiles, the DDs reached approximately 5.0% in the whole area because of penumbra area, while the DDs in the central, shoulder, and extended areas were within 1.0%, 2.0%, and 1.0%, respectively. The DTAs in the penumbra area were within 0.8 mm. CONCLUSIONS: The supplied RBPs can be used clinically owing to the good agreement with the accurate MBPs with rigid board.


Asunto(s)
Aceleradores de Partículas , Planificación de la Radioterapia Asistida por Computador , Dosificación Radioterapéutica
7.
Artículo en Japonés | MEDLINE | ID: mdl-32307361

RESUMEN

PURPOSE: Novel linac improvements in speed of gantry, collimator, leaf and dose rate may increase the time-efficiency of volumetric modulated arc therapy (VMAT) delivery, however remains to be investigated. In this study, a fast-rotating O-ring linac (Halcyon) with fast moving leaves is compared with a general linac (TrueBeam: TB) in terms of plan quality for VMAT of C-shape, prostate, multi target and, head and neck (H&N) cases from AAPM TG-119. MATERIALS AND METHODS: For the four test cases, VMAT planning was performed using single to four-arc VMAT on a Halcyon and using single to three-arc VMAT on a TrueBeam. Same conditions for optimization were used in each test case. Target coverage metrics and organ at risks (OAR) dose were compared. Monitor unit (MU) and irradiation time in each plan were also compared. RESULTS: In all cases, single-arc plans of Halcyon were inferior to TB plans on dose objectives. Conformity index (CI) to outer target of C-shape case was better for Halcyon (1-arc: 1.242, 2-arc: 1.202, 3-arc: 1.198, 4-arc: 1.181) than for TB (1-arc: 1.247, 2-arc: 1.211, 3-arc: 1.211) except to single arc. D5 (Gy) of core for C-shape case was better for halcyon (1-arc: 23.29, 2-arc: 21.01, 3-arc: 20.64, 4-arc: 20.47) than for TB (1-arc: 24.04, 2-arc: 22.94, 3-arc: 23.04). Calculated MU was smaller for Halcyon than for TB. In addition, Halcyon is more faster than TB because mechanical movements were improved. CONCLUSION: For VMAT plan in each case, Halcyon as well or better at the plan quality of two or three arcs on TB while reducing the delivery time.


Asunto(s)
Radioterapia de Intensidad Modulada , Masculino , Aceleradores de Partículas , Próstata , Dosificación Radioterapéutica , Planificación de la Radioterapia Asistida por Computador
8.
Phys Med ; 63: 19-24, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-31221404

RESUMEN

PURPOSE: The influence of the offset distance from treatment target to gantry isocenter (GIC) on the dosimetric parameter and irradiation time was investigated using TomoTherapy METHODS: The reference position was defined as the centers of both the I'mRT phantom and planning target volume (PTV) with a spherical of 4 cm diameter aligned with the GIC. The dose calculations were performed in two offset methods with 2 and 12 Gy/fr, Method 1. The PTV was moved from 0.0 to 12.5 cm along the RL direction and -5.0 to 5.0 cm along the AP direction (PTV offset), Method 2. The phantom was moved from 0.0 to -7.5 cm along the RL direction and -5.0 to 5.0 cm along the AP direction (Phantom offset). The maximum, minimum and mean doses, homogeneity index, conformity index, irradiation time, and monitor unit were compared. RESULTS: The irradiation times increased with increasing PTV offset. The increases in the irradiation time were 54.4% and 40.8% at PTV offsets of 12.5 cm along the RL direction for 2 and 12 Gy/fr, while the increases were 20.1% and 15.0% at a PTV offset of 5.0 cm along the AP direction. An increased irradiation time was not observed for the phantom offset. The offset didn't affect the other parameters. CONCLUSIONS: The PTV location offset of ≥5 cm from the GIC along the RL and AP axes increased the irradiation time; therefore, the PTV should be aligned with the GIC as much as possible to reduce the irradiation time on TomoTherapy.


Asunto(s)
Fantasmas de Imagen , Planificación de la Radioterapia Asistida por Computador/instrumentación , Radiometría , Dosificación Radioterapéutica , Radioterapia de Intensidad Modulada , Factores de Tiempo
9.
Artículo en Japonés | MEDLINE | ID: mdl-30787223

RESUMEN

PURPOSE: The dosimetric error due to immobilization devices has been highlighted by the AAPM Task Group 176. We developed a novel low-radiation-absorbent immobilization adaptor (HMA), which can be used with a Styrofoam headrest for head and neck region in radiotherapy. The purpose of this study was to investigate the impact of the HMA on the dose distribution and compare with a commercially released plastic adapter. METHODS: Computed tomography (CT) simulation and dose calculation on a treatment planning system (TPS) were performed by the use of HMA and the plastic adapter with a cylindrical phantom. Both the adapters were placed on the phantom upside and the attenuation rate was measured. Gantry angles were changed at every 1°interval from 0°to 50°for measurements. The measured dose was normalized by the value of 90°. The treatment equipment was TrueBeam (Varian medical systems); X-ray energies were set on 4, 6 and 10 MV, respectively. The measured attenuation rates were also compared with calculation results of TPS. RESULTS: The highest differences on attenuation rate of both the adapters were observed at a gantry angle of 32.0°; the differences were 3.0% at 4 MV, 2.7% at 6 MV and 3.0% at 10 MV, respectively, and lower absorption was HMA. TPS calculation results of monitor unit for the HMA were within 1.0% in each energy. CONCLUSION: The HMA was able to provide absorption dose and calculation errors lower than a commercially released adapter. It can also provide more accurate dose delivery for radiotherapy in head and neck because of the low absorption characteristics.


Asunto(s)
Neoplasias de Cabeza y Cuello , Planificación de la Radioterapia Asistida por Computador , Radioterapia de Intensidad Modulada , Neoplasias de Cabeza y Cuello/radioterapia , Humanos , Fantasmas de Imagen , Radiometría , Dosificación Radioterapéutica
10.
Igaku Butsuri ; 38(2): 85-88, 2018.
Artículo en Japonés | MEDLINE | ID: mdl-30381718

RESUMEN

18F-FDG PET/CT has an important role in radiation therapy planning. FDG PET/CT parameters such as standard uptake value and metabolic tumor volume provide important prognostic and predictive information. Importantly, FDG PET/CT for radiation planning has added biological information in defining the gross tumor volume (GTV) as well as involved nodal disease. Several studies have shown that PET has an impact on radiation therapy planning in an important proportion of patients.On the other hands, FDG PET/CT for radiation therapy planning has several limitations. First of all, the method to determine the optimal threshold of FDG PET/CT images that generates the best volumetric match to GTV is not established. The size of the GTV derived from FDG accumulation changes significantly depending on the threshold value, the threshold value can affect the clinical target delineation. Secondly, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. PET/CT simulation for radiation therapy planning requires cooperation of other professions and sufficient physical assessment.


Asunto(s)
Tomografía Computarizada por Tomografía de Emisión de Positrones , Planificación de la Radioterapia Asistida por Computador , Tomografía Computarizada por Rayos X , Fluorodesoxiglucosa F18 , Humanos , Neoplasias/radioterapia , Tomografía de Emisión de Positrones , Radiofármacos
11.
Anticancer Res ; 38(5): 2733-2738, 2018 05.
Artículo en Inglés | MEDLINE | ID: mdl-29715093

RESUMEN

BACKGROUND/AIM: Patient immobilization systems are used to establish a reproducible patient position relative to the couch. In this study, the impact of conventional lok-bars for CT-simulation (CIVCO-bar) and treatment (iBEAM-bar) were compared with a novel lok-bar (mHM-bar) in tomotherapy. MATERIALS AND METHODS: Verification was obtained as follows: i. artifacts in CT images; ii. dose attenuation rate of lok-bar, compared to without lok-bar; and iii. dose differences between the calculated and measured absorbed doses. RESULTS: With the CIVCO-bar, there were obvious metal artifacts, while there were nearly no artifacts with the mHM-bar. The mean dose attenuation rates with the mHM-bar and iBEAM-bar were 1.31% and 2.28%, and the mean dose difference was 1.55% and 1.66% for mHM-bar and iBEAM-bar. CONCLUSION: Using the mHM-bar reduced artifacts on the CT image and improved dose attenuation are obtained. The lok-bar needs to be inserted as a structure set in treatment planning with tomotherapy.


Asunto(s)
Posicionamiento del Paciente/instrumentación , Radioterapia de Intensidad Modulada/métodos , Absorción de Radiación , Artefactos , Relación Dosis-Respuesta en la Radiación , Diseño de Equipo , Humanos , Fantasmas de Imagen , Radiometría , Planificación de la Radioterapia Asistida por Computador , Tomografía Computarizada por Rayos X/métodos
12.
In Vivo ; 32(3): 531-536, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-29695556

RESUMEN

AIM: In this study, we clarified changes of the surface dose to a low-density material on a carbon couch and verified whether a novel rigid couch (HM couch) could reduce the surface dose. MATERIALS AND METHODS: We measured the surface dose using only a carbon couch (iBeam Couchtop STANDARD; BrainLab), a low-density material (Styrofoam board) on the carbon couch, and an HM couch for 6 and 10 MV photon beams. RESULTS: A 5-cm styrofoam board placed on the carbon couch reduced the surface dose by approximately 7-9%, while it had no impact on the depth dose profile; however, in use, such a thickness may cause collision of the patient with the gantry head. The HM couch reduced the surface dose by approximately 7-9% and shifted the depth dose profile by approximately 0.4 cm in the depth direction compared to the carbon couch. CONCLUSION: The HM couch has the potential to reduce skin toxicity and is expected to be useful in clinical practice instead of carbon couches.


Asunto(s)
Carbono , Dosificación Radioterapéutica , Radioterapia/efectos adversos , Piel/efectos de la radiación , Relación Dosis-Respuesta en la Radiación , Humanos , Fotones , Radiometría
13.
Igaku Butsuri ; 35(4): 282-291, 2016.
Artículo en Japonés | MEDLINE | ID: mdl-28428463

RESUMEN

The purpose of this study is to evaluate the mechanical accuracy of a respiratory-gated radiation system that combines the Linear Indicator-equipped Abches respiration-monitoring device and the Varian Real-time Position Management system (LI-RPM system). This combined configuration, implemented for the first time in Japan, was compared with the stand-alone Varian RPM system (RPM system). The delay times, dose profiles, and output waveforms of the LI-RPM and RPM systems were evaluated using a self-produced dynamic phantom. The delay times for the LI-RPM and RPM systems were both 0.1 s for 4 s and 8 s test periods. The corresponding output waveform correlation factors (R2) for the 4 s and 8 s test periods were 0.9981 and 0.9975, respectively. No difference was observed in the dose profiles of the two systems. Thus, the present results indicate that the proposed LI-RPM combined respiratory-gated radiation system has similar properties to the RPM system. However, it offers several advantages in terms of its versatility, including its alignment assistance capabilities for non-coplanar treatments.


Asunto(s)
Monitoreo Fisiológico/instrumentación , Radioterapia/métodos , Respiración , Humanos , Monitoreo Fisiológico/métodos , Fantasmas de Imagen , Radioterapia/instrumentación
14.
Radiother Oncol ; 106(1): 85-9, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23337058

RESUMEN

PURPOSE: The aim of this study was to show the benefit of a two-step intensity modulated radiotherapy (IMRT) method by examining geometric and dosimetric changes. MATERIAL AND METHODS: Twenty patients with pharyngeal cancers treated with two-step IMRT combined with chemotherapy were included. Treatment-planning CT was done twice before IMRT (CT-1) and at the third or fourth week of IMRT for boost IMRT (CT-2). Transferred plans recalculated initial plan on CT-2 were compared with the initial plans on CT-1. Dose parameters were calculated for a total dose of 70 Gy for each plan. RESULTS: The volumes of primary tumors and parotid glands on CT-2 regressed significantly. Parotid glands shifted medially an average of 4.2mm on CT-2. The mean doses of the parotid glands in the initial and transferred plans were 25.2 Gy and 30.5 Gy, respectively. D(2) (dose to 2% of the volume) doses of the spinal cord were 37.1 Gy and 39.2 Gy per 70 Gy, respectively. Of 15 patients in whom xerostomia scores could be evaluated 1-2 years after IMRT, no patient complained of grade 2 or more xerostomia. CONCLUSIONS: This two-step IMRT method as an adaptive RT scheme could adapt to changes in body contour, target volumes and risk organs during IMRT.


Asunto(s)
Neoplasias de Cabeza y Cuello/radioterapia , Radioterapia de Intensidad Modulada/métodos , Neoplasias de Cabeza y Cuello/patología , Humanos , Glándula Parótida/efectos de la radiación , Dosificación Radioterapéutica , Carga Tumoral
15.
Radiol Phys Technol ; 6(1): 210-8, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23208723

RESUMEN

Dosimetric properties of an amorphous silicon electronic portal imaging device (EPID) for verification of intensity-modulated radiation therapy (IMRT) were investigated as a replacement for conventional verification tools. The portal dosimetry system of Varian's EPID (aS1000) has an integrated image mode for portal dosimetry (PD). The source-to-imager distance was 105 cm, and there were no extra buildup materials on the surface of the EPID in this study. Several dosimetric properties were examined. For clinical dosimetry, the dose distributions of dynamic IMRT beams for prostate cancer (19 patients, 97 beams) were measured by EPID and compared with the results of ionization chamber (IC) measurements. In addition, pretreatment measurements for prostate IMRT (50 patients, 309 beams) were performed by EPID and were evaluated by the gamma method (criterion: 3 mm/3 %). The signal-to-monitor unit ratio of PD showed dose dependence, indicating ghosting effects. Tongue-and-groove effects were observed as a result of the dose difference in the measured EPID images. The results of PD for clinical IMRT beams were in good agreement with the predicted dose image with average values of 1.37 and 0.25 for γ (max) and γ (ave), respectively. The point doses of PD were slightly, but significantly, higher than the results of IC measurements (p < 0.05 paired t test). However, this small difference seems clinically acceptable. This portal dosimetry system is useful as a rapid and convenient verification tool for dynamic IMRT.


Asunto(s)
Equipos y Suministros Eléctricos , Radioterapia Guiada por Imagen/instrumentación , Radioterapia de Intensidad Modulada/instrumentación , Silicio , Humanos , Masculino , Neoplasias de la Próstata/diagnóstico , Neoplasias de la Próstata/radioterapia , Control de Calidad , Radiometría , Dosificación Radioterapéutica , Radioterapia Guiada por Imagen/normas , Radioterapia de Intensidad Modulada/normas , Relación Señal-Ruido
16.
J Radiat Res ; 54(3): 561-8, 2013 May.
Artículo en Inglés | MEDLINE | ID: mdl-23239175

RESUMEN

Respiratory motion management (RMM) systems in external and stereotactic radiotherapies have been developed in the past two decades. Japanese medical service fee regulations introduced reimbursement for RMM from April 2012. Based on thorough discussions among the four academic societies concerned, these Guidelines have been developed to enable staff (radiation oncologists, radiological technologists, medical physicists, radiotherapy quality managers, radiation oncology nurses, and others) to apply RMM to radiation therapy for tumors subject to respiratory motion, safely and appropriately.


Asunto(s)
Neoplasias/radioterapia , Posicionamiento del Paciente/normas , Garantía de la Calidad de Atención de Salud/normas , Oncología por Radiación/normas , Protección Radiológica/normas , Radioterapia Conformacional/normas , Mecánica Respiratoria , Humanos , Japón , Movimiento
17.
Phys Rev Lett ; 109(23): 235302, 2012 Dec 07.
Artículo en Inglés | MEDLINE | ID: mdl-23368216

RESUMEN

We propose a method to create a nontrivial Haldane phase in an atomic two-component Fermi gas loaded on a one-dimensional optical lattice with trap potential. The Haldane phase is naturally formed on a p-band Mott core in a wide range of the strong on-site repulsive interaction. The present proposal is composed of two steps, one of which is theoretical derivation of an effective 1D S=1 interacting-chain model from the original tight-binding Hamiltonian handling the two p orbitals, and the other of which is a numerical demonstration employing the density-matrix renormalization group for the formation of the Haldane phase on a p-band Mott core and its associated features in the original tight-binding model with the harmonic trap potential.

18.
Int J Radiat Oncol Biol Phys ; 77(2): 350-6, 2010 Jun 01.
Artículo en Inglés | MEDLINE | ID: mdl-20457349

RESUMEN

PURPOSE: Clinical applicability of a multiple-threshold method for [(18)F]fluoro-2-deoxyglucose (FDG) activity in radiation treatment planning was evaluated. METHODS AND MATERIALS: A total of 32 patients who underwent positron emission and computed tomography (PET/CT) simulation were included; 18 patients had lung cancer, and 14 patients had pharyngeal cancer. For tumors of 5 cm, thresholds were defined as 2.5 standardized uptake value (SUV), 35%, and 20% of the maximum FDG activity, respectively. The cervical and mediastinal lymph nodes with the shortest axial diameter of >or=10 mm were considered to be metastatic on CT (LNCT). The retropharyngeal lymph nodes with the shortest axial diameter of >or=5 mm on CT and MRI were also defined as metastatic. Lymph nodes showing maximum FDG activity greater than the adopted thresholds for radiation therapy planning were designated LNPET-RTP, and lymph nodes with a maximum FDG activity of >or=2.5 SUV were regarded as malignant and were designated LNPET-2.5 SUV. RESULTS: The sizes of gross tumor volumes on PET (GTVPET) with the adopted thresholds in the axial plane were visually well fitted to those of GTV on CT (GTVCT). However, the volumes of GTVPET were larger than those of GTVCT, with significant differences (p < 0.0001) for lung cancer, due to respiratory motion. For lung cancer, the numbers of LNCT, LNPET-RTP, and LNPET-2.5 SUV were 29, 28, and 34, respectively. For pharyngeal cancer, the numbers of LNCT, LNPET-RTP, and LNPET-2.5 SUV were 14, 9, and 15, respectively. CONCLUSIONS: Our multiple thresholds were applicable for delineating the primary target on PET/CT simulation. However, these thresholds were inaccurate for depicting malignant lymph nodes.


Asunto(s)
Fluorodesoxiglucosa F18 , Neoplasias Pulmonares/diagnóstico por imagen , Ganglios Linfáticos/diagnóstico por imagen , Neoplasias Faríngeas/diagnóstico por imagen , Tomografía de Emisión de Positrones/métodos , Radiofármacos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Fluorodesoxiglucosa F18/farmacocinética , Humanos , Neoplasias Pulmonares/patología , Neoplasias Pulmonares/radioterapia , Metástasis Linfática/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Neoplasias Faríngeas/patología , Neoplasias Faríngeas/radioterapia , Radiofármacos/farmacocinética , Planificación de la Radioterapia Asistida por Computador , Tasa de Supervivencia , Tomografía Computarizada por Rayos X/métodos , Carga Tumoral , Adulto Joven
19.
Jpn J Clin Oncol ; 40(2): 130-8, 2010 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-19841102

RESUMEN

OBJECTIVE: The aim of this study was to analyze the clinical results of our adaptive radiation therapy scheme of a two-step intensity-modulated radiotherapy (IMRT) method for nasopharyngeal cancer (NPC) at Kinki University Hospital. METHODS: Between 2000 and 2007, 35 patients with Stage I-IVB NPC treated by IMRT were included. For all patients, treatment-planning computed tomography was done twice before and during IMRT to a total dose of 60-70 Gy/28-35 fractions (median 68 Gy). Chemotherapy (cisplatin 80 mg/m(2)/3 weeks x 1-3 courses) was given concurrently with IMRT for 31 patients. RESULTS: The 3- and 5-year overall survival rates for the 31 patients treated with concurrent chemotherapy were 88% and 83%, respectively. The 3- and 5-year loco-regional control rates for the 31 patients were 93% and 87%, respectively. Planning target volume delineation for the primary site or involved nodes was insufficient for three early cases, resulting in marginal recurrence in the three patients (9%). Except for one patient with early death, xerostomia scores at 1-2 years were: Grade 0, 11; Grade 1, 17; Grade 2, 5; Grade 3, 1. CONCLUSIONS: Excellent overall survival and loco-regional control rates were obtained by a two-step IMRT method with concurrent chemotherapy for NPC, although marginal recurrence was noted in some early cases.


Asunto(s)
Neoplasias Nasofaríngeas/radioterapia , Radioterapia de Intensidad Modulada , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Antineoplásicos/uso terapéutico , Cisplatino/uso terapéutico , Terapia Combinada , Femenino , Humanos , Japón , Masculino , Persona de Mediana Edad , Neoplasias Nasofaríngeas/tratamiento farmacológico , Neoplasias Nasofaríngeas/mortalidad , Estadificación de Neoplasias , Dosificación Radioterapéutica , Estudios Retrospectivos , Adulto Joven
20.
Med Phys ; 36(7): 2992-3001, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19673198

RESUMEN

The purpose of this study is to calculate correction factors for plastic water (PW) and plastic water diagnostic-therapy (PWDT) phantoms in clinical photon and electron beam dosimetry using the EGSnrc Monte Carlo code system. A water-to-plastic ionization conversion factor k(pl) for PW and PWDT was computed for several commonly used Farmer-type ionization chambers with different wall materials in the range of 4-18 MV photon beams. For electron beams, a depth-scaling factor c(pl) and a chamber-dependent fluence correction factor h(pl) for both phantoms were also calculated in combination with NACP-02 and Roos plane-parallel ionization chambers in the range of 4-18 MeV. The h(pl) values for the plane-parallel chambers were evaluated from the electron fluence correction factor phi(pl)w and wall correction factors P(wall,w) and P(wall,pl) for a combination of water or plastic materials. The calculated k(pl) and h(pl) values were verified by comparison with the measured values. A set of k(pl) values computed for the Farmer-type chambers was equal to unity within 0.5% for PW and PWDT in photon beams. The k(pl) values also agreed within their combined uncertainty with the measured data. For electron beams, the c(pl) values computed for PW and PWDT were from 0.998 to 1.000 and from 0.992 to 0.997, respectively, in the range of 4-18 MeV. The phi(pl)w values for PW and PWDT were from 0.998 to 1.001 and from 1.004 to 1.001, respectively, at a reference depth in the range of 4-18 MeV. The difference in P(wall) between water and plastic materials for the plane-parallel chambers was 0.8% at a maximum. Finally, h(pl) values evaluated for plastic materials were equal to unity within 0.6% for NACP-02 and Roos chambers. The h(pl) values also agreed within their combined uncertainty with the measured data. The absorbed dose to water from ionization chamber measurements in PW and PWDT plastic materials corresponds to that in water within 1%. Both phantoms can thus be used as a substitute for water for photon and electron dosimetry.


Asunto(s)
Electrones , Método de Montecarlo , Fantasmas de Imagen , Fotones , Plásticos , Radiometría/métodos , Algoritmos , Simulación por Computador , Modelos Teóricos , Aceleradores de Partículas , Agua/química
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