Optimization of Electrochemical Sensitivity in Anticancer Drug Quantification through ZnS@CNS Nanosheets: Synthesis via Accelerated Sonochemical Methodology.

Zinc sulfide/graphitic Carbon Nitride binary nanosheets were synthesized by using a novel sonochemical pathway with high electrocatalytic ability. The as- obtained samples were characterized by various analytical methods such as Transmission Electron Microscopy (TEM), Field emission scanning electron microscopy (FESEM), Energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction analysis (XRD), and X-ray photoelectron spectroscopy (XPS) to evaluate the properties of ZnS@CNS synthesized by this new route. Subsequently, the electrical and electrochemical performance of the proposed electrodes were characterized by using EIS and CV to establish an electroactive ability of the nanocomposites. The complete properties like structural and physical of ZnS@CNS were analyzed. As-prepared binary nanocomposite was applied towards the detection of anticancer drug (flutamide) by various electrochemical methods such as cyclic voltammetry (CV), differential pulse voltammetry (DPV) and amperometry. The glassy carbon electrode modified with a ZnS@CNS composite demonstrates a remarkable electrocatalytic efficiency for detecting flutamide in a pH 7.0 (PBS). The composite modified electrode shows synergistic effect of ZnS and CNS catalyst. The electrochemical sensing performance of the linear range was improved significantly due to high electroactive sites and rapid electron transport pathways. Crucially, the electrochemical method was successfully demonstrated in biological fluids which reveals its potential real-time applicability in the analysis of drug.

Fabrication of a novel tantalum boride/vanadium carbide modified screen-printed carbon electrode for voltammetric determination of pimonidazole in bio-fluids.

For the first time, a tumour hypoxia marker detection has been developed using two-dimensional layered composite modified electrodes in biological and environmental samples. The concept of TaB2 and V4C3-based MXene composite materials is not reported hitherto using ball-milling and thermal methods and it remains the potentiality of the present work. The successful formation is confirmed through various characterisation techniques like X-ray crystallography, scanning electron microscopy photoelectron, and impedance spectroscopy. A reliable and repeatable electrochemical sensor based on TaB2@V4C3/SPCE was developed for quick and extremely sensitive detection of pimonidazole by various electroanalytical methods. It has been shown that the modified electrode intensifies the reduction peak current and causes a decrease in the potential for reduction, in comparison with the bare electrode. The proposed sensor for pimonidazole reduction has strong electrocatalytic activity and high sensitivity, as demonstrated by the cyclic voltammetry approach. Under the optimal experimental circumstances, differential pulse voltammetry techniques were utilised for generating the wide linear range (0.02 to 928.51 µM) with a detection limit of 0.0072 µM. The resultant data demonstrates that TaB2@V4C3/SPCE nano-sensor exhibits excellent stability, reliability, and repeatability in the determination of pimonidazole. Additionally, the suggested sensor was successfully used to determine the presence of pimonidazole in several real samples, such as human blood serum, urine, water, and drugs.

A sonochemical synthesis of SrTiO3 supported N-doped graphene oxide as a highly efficient electrocatalyst for electrochemical reduction of a chemotherapeutic drug.

A sonochemical based green synthesis method playa powerful role in nanomaterials and composite development. In this work, we developed a perovskite type of strontium titanate via sonochemical process. SrTiO3 particles were incorporated with nitrogen doped graphene oxide through simple ultrasonic irradiation method. The SrTiO3/NGO was characterized by various analytical methods. The nanocomposite of SrTiO3/NGO was modified with laser-induced graphene electrode (LIGE). The SrTiO3/NGO/LIGE was applied for electrochemical sensor towards chemotherapeutic drug detection (nilutamide). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques have been used to examine the electrochemical performance of nilutamide (anti-cancer drug). DPV was found to be more sensitive and found to exhibit a sensitivity 8.627 µA µM-1 cm-2 for SrTiO3/NGO/LIGE with a wide linear range (0.02-892 µM) and low Limit of detection (LOD: 1.16 µM). SrTiO3/NGO/LIGE has been examined for the detection of nilutamide in blood serum and urine samples and obtained a good recovery in the range of 97.2-99.72 %. The enhanced stability and selectivity and practical application results indicates the suitability of SrTiO3/NGO/LIGE towards the detection of nilutamide drug in pharmaceutical industries.

Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin.

Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate's related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS. In contrast to other electrodes reported in the literature, a much-improved electrochemical efficiency is shown by FeV/SCNF composite modified electrodes. Amperometric technique has been employed at 0.25 V (vs. Ag/AgCl) for the sensitive detection of DOX within a wide range of 20 nM-542.5 µM and it possesses enhanced selectivity in presence of common interferents. The modified electrochemical sensors show high sensitivity of 46.041 µA µM-1 cm-2. The newly developed sensor could be used for the determination of doxorubicin in both blood serum and drug formulations with acceptable results, suggesting its feasibility for real-time applications.

Sonochemical synthesis and fabrication of perovskite type calcium titanate interfacial nanostructure supported on graphene oxide sheets as a highly efficient electrocatalyst for electrochemical detection of chemotherapeutic drug.

In green approaches for electrocatalyst synthesis, sonochemical methods play a powerful role in delivering the abundant surface areas and nano-crystalline properties that are advantageous to electrocatalytic detection. In this article, we proposed the sphere-like and perovskite type of bimetal oxides which are synthesized through an uncomplicated sonochemical procedure. As a yield, the novel calcium titanate (orthorhombic nature) nanoparticles (CaTiO3 NPs) decorated graphene oxide sheets (GOS) were obtained through simple ultrasonic irradiation by a high-intensity ultrasonic probe (Titanium horn; 50 kHz and 60 W). The GOS/CaTiO3 NC were characterized morphologically and chemically through the analytical methods (SEM, XRD, and EDS). Besides, as-prepared nanocomposites were modified on a GCE (glassy carbon electrode) and applied towards electrocatalytic and electrochemical sensing of chemotherapeutic drug flutamide (FD). Notably, FD is a crucial anticancer drug and also a non-steroidal anti-androgen chemical. Mainly, the designed and modified sensor has shown a wide linear range (0.015-1184 µM). A limit of detection was calculated as nanomolar level (5.7 nM) and sensitivity of the electrode is 1.073 µA µM-1 cm-2. The GOS/CaTiO3 modified electrodes have been tested in human blood and urine samples towards anticancer drug detection.

A sensitive electrochemical determination of chemotherapy agent using graphitic carbon nitride covered vanadium oxide nanocomposite; sonochemical approach.

We have developed a graphitic carbon nitride covered vanadium oxide nanocomposite (V2O5@g-C3N4) by a simple sonochemical approach (50 kHz and 150 W/cm2). Furthermore, the morphology and chemical composition of the V2O5@g-C3N4 nanocomposite was carried out by X-rays diffractometry (XRD), transmission electron microscopy (TEM) and electrochemical impedance spectroscopy (EIS). Furthermore, the V2O5@g-C3N4 nanocomposite modified electrode was investigate electrochemical behavior of the anticancer drug. Compared with bare SPCE, V2O5/SPCE and g-C3N4/SPCE, V2O5@g-C3N4 modified SPCE showed highest current response towards anti-cancer drug (methotrexate). Furthermore, the modified sensor exhibits with a sharp peaks and wide linear range (0.025-273.15 µM) by using DPV with the sensitivity of 7.122 µA µM-1 cm-2. Notably, we have achieved a nanomolar detection limit (13.26 nM) for the DPV detection of methotrexate. Further, the practicability of the V2O5@g-C3N4 nanocomposite modified sensor can be used for real time sensing of methotrexate in drug and blood serum samples with good recover ranges. It has potential applications in routine analysis with high specificity, excellent reproducibility and good stability.

A novel nanocomposite with superior electrocatalytic activity: A magnetic property based ZnFe2O4 nanocubes embellished with reduced graphene oxide by facile ultrasonic approach.

Herein, a novel Zinc Ferrite nanocubes (ZnFe2O4 NCs) decorated reduced graphene oxide (rGO) nanocomposite have been designed through a sonochemical method. After then, as-synthesized ZnFe2O4 NCs/rGO was characterized by XPS, XRD, HRTEM and EIS. Furthermore, the ZnFe2O4 NCs/rGO nanocomposite modified GCE (glassy carbon electrode) shows excellent electrochemical sensing performance towards biomarker of 4-nitroquinoline N-oxide (4-NQ) with fast detection. 4-NQ is one of the important cancer biomarker. Moreover, the fabricated sensor showed a wide linear window for 4-NQ between 0.025 and 534.12 µM and nanomolar detection limit (8.27 nM). Further, the as-prepared ZnFe2O4 NCs/rGO/GCE has been applied to the determination of 4-NQ in human blood and urine samples with excellent recovery results.

Facile synthesis of mesoporous WS2 nanorods decorated N-doped RGO network modified electrode as portable electrochemical sensing platform for sensitive detection of toxic antibiotic in biological and pharmaceutical samples.

We report a facile and ultrasound assisted sonochemical synthesis of a Tungsten disulfide nanorods decorated nitrogen-doped reduced graphene oxide based nanocomposite. The WS2 NRs/N-rGOs nanocomposite was characterized by FESEM, HRTEM, XRD, XPS and electrochemical methods and its application towards the electrochemical detection of organo-arsenic drug (coccidiostat). The WS2 NRs/N-rGOs modified SPCE was used for the electrochemical reduction of roxarsone (ROX) and it showed superior electrocatalytic performance in terms of reduction peak current and shift in overpotential when compared to those of WS2 NRs/SPCE, N-rGOs/SPCE and based SPCE. The WS2 NRs/N-rGOs modified SPCE showed an excellent sensing ability towards ROX in nitrogen saturated phosphate buffer (PB) then the other controlled modified and unmodified electrodes. The WS2 NRs/N-rGOs/SPCE displays high sensitive response towards ROX and gives wide linearity in the range of 0.1-442.6 µM ROX in neutral phosphate buffer (pH 7.0) and the sensitivity of the sensor is calculated as 14.733 µA µM-1 cm-2. The WS2 NRs/N-rGOs nanocomposite modified sensor also exhibits valuable ability of anti-interference to electroactive analytes. Furthermore, the as-prepared WS2 NRs/N-rGOs/SPCE has been applied to the determination of ROX in biological and pharmaceutical samples.

One-pot sonochemical synthesis of Bi2WO6 nanospheres with multilayer reduced graphene nanosheets modified electrode as rapid electrochemical sensing platform for high sensitive detection of oxidative stress biomarker in biological sample.

4-Nitroquinoline N-oxide (4-NQO) is an important tumorigenic organic compound with high adverse effect in the human body. In this study, a novel Bismuth Tungstate nanospheres (Bi2WO6) decorated reduced graphene oxide (Bi2WO6/rGOS) nanocomposite have been designed through a sonochemical method. The as-synthesized Bi2WO6/rGOS was characterized through the HRTEM, FESEM, XPS, EIS and XRD. Furthermore, the nanocomposite modified glassy carbon electrode (GCE) was developed for the determination of 4-NQO. The results showed that the Bi2WO6/rGOS nanocomposite modified electrode exhibit valuable responses and excellent electrocatalytic activity. The fabricated sensor was facilitated the analysis of 4-NQO with a nanomolar detection limit (6.11 nM). Further, the as-synthesized Bi2WO6/rGOS modified electrode has been applied to sensing of 4-NQO in human blood and urine samples with satisfactory recovery.

Rapid sonochemical synthesis of silver nano-leaves encapsulated on iron pyrite nanocomposite: An excellent catalytic application in the electrochemical detection of herbicide (Acifluorfen).

Herein, we developed a silver nanoparticles decorated iron pyrite flowers (FeS2@Ag NL) based nanocomposite was prepared by a sonochemical method. The formation of FeS2@Ag NL nanocomposite was confirmed by XRD, XPS, HR-TEM and analytical techniques. The FeS2@Ag NL/SPCE was potentially applied towards electrochemical detection of toxic herbicide (acifluorfen-AFF). This provided an efficient sensor platform anchoring FeS2@Ag NL on its surface. Under optimized conditions of differential pulse voltammetric transduction, a linear relationship between the current and the concentration was obtained in the range of 0.05-1126.45 µM for Acifluorfen. The detection limit was observed to be 0.0025 µM. the modified sensor exhibits excellent electrochemical performance, including good linear range, nanomolar detection limit, high sensitivity, and desirable stability. Particularly, the practical applicability was revealed by quantifying the AFF concentration in biological samples.

Determination of the antioxidant propyl gallate in meat by using a screen-printed electrode modified with CoSe2 nanoparticles and reduced graphene oxide.

A voltammetric sensor is described for the quantitation of propyl gallate (PG). A screen-printed carbon electrode (SPCE) was modified with reduced graphene sheets that were decorated with cobalt diselenide nanoparticles (CoSe2@rGO). The material was hydrothermally prepared and characterized by several spectroscopic techniques. The modified SPCE displays excellent electrocatalytic ability towards PG. Differential pulse voltammetry, with a peak voltage at 0.34 V (vs. Ag/AgCl) has a sensitivity of 12.84 µA·µM-1·cm-2 and a detection limit as low as 16 nM. The method is reproducible, selective, and practical. This method was applied to the determination of PG in spiked meat samples, and the result showed an adequate recovery. Graphical abstract Schematic of a new method for fast and sensitive electrochemical determination of the food additive propyl gallate in meat.