Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 5 de 5
Filtrar
1.
Langenbecks Arch Surg ; 407(8): 3691-3699, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36094764

RESUMEN

PURPOSE: The influence of cancer development on long-term outcome after elective endovascular (EVAR) vs. open repair (OAR) of non-ruptured abdominal aortic aneurysms (AAA) was investigated. METHODS: Patient survival and cancer incidence were recorded for 18,802 patients registered with the AOK health insurance company in Germany who underwent EVAR (n = 14,218) and OAR (n = 4584) in the years 2010 to 2016 (men n = 16,086, women n = 2716). All patients were preoperatively and in their history cancer-free. RESULTS: 30.1% of EVAR and 27.6% of OAR patients (p ≤ .001) developed cancer after a follow-up period of up to 9 years (Kaplan-Meier estimated). Patients with cancer had a significantly less favorable outcome compared to patients with no cancer (HR 1.68; 95% CI 1.59-1.78, p < .001). After 9 years, the estimated survival of patients with and without cancer was 27.0% and 55.4%, respectively (p < .001). Survival of men and women did not differ significantly (HR 0.94; 95% CI 0.88-1.00, p = .061). In the Cox regression analysis (adjusted outcomes by operative approach, gender, age, and comorbidities), the postoperative cancer incidence was not significantly different between EVAR and OAR (HR 1.09; 95% CI 1.00-1.18, p = .051). However, EVAR showed an increased risk of postoperative development of abdominal cancer (HR 1.20; 95% CI 1.07-1.35, p = .002). 48.0% of all EVAR patients and 53.4% of all OAR patients survived in the follow-up period of up to 9 years. This difference was not significant (HR 0.96; 95% CI 0.91-1.02, p = .219). CONCLUSION: Cancer significantly worsened the long-term outcome after EVAR and OAR, without significant differences between the two repair methods in the overall cancer incidence. However, the higher abdominal cancer incidence with EVAR can affect quality of life including oncological therapy and therefore should be considered when determining the indication for surgery, and the patient should be informed about it.


Asunto(s)
Aneurisma de la Aorta Abdominal , Implantación de Prótesis Vascular , Procedimientos Endovasculares , Neoplasias , Masculino , Humanos , Femenino , Aneurisma de la Aorta Abdominal/epidemiología , Aneurisma de la Aorta Abdominal/cirugía , Procedimientos Endovasculares/métodos , Calidad de Vida , Factores de Riesgo , Resultado del Tratamiento , Factores de Tiempo , Estudios Retrospectivos , Implantación de Prótesis Vascular/efectos adversos , Complicaciones Posoperatorias/etiología , Neoplasias/cirugía
2.
Chirurg ; 92(9): 830-837, 2021 Sep.
Artículo en Alemán | MEDLINE | ID: mdl-33095283

RESUMEN

BACKGROUND: The MTL30 (mortality, transfer, length of stay) was proposed as a surrogate parameter for evaluating the quality of large and potentially complication-prone visceral surgical interventions. OBJECTIVE: The aim of this study was to find out to what extent the MTL30 can be correlated with the results of the abdominal aortic aneurysm (AAA) registry of the German Institute for Vascular Health Research (DIGG) of the German Society for Vascular Surgery and Vascular Medicine (DGG) and with the case volume of the participating hospitals. MATERIAL AND METHODS: Elective endovascular abdominal aortic aneurysm repair (EVAR) was performed in 14,282 patients and open repair (OAR) in 3923 patients. Case volume of the treating hospitals, hospital mortality, length of stay and transfer to another acute care hospital were determined 30 days after the index intervention. RESULTS: The hospital mortality was 1.3% for EVAR and 4.9% for OAR (p = 0.000), the MTL30 was 5.0% and 14.4%, respectively (p = 0.000). For EVAR, no relationship between case volume and hospital mortality (quintile 1: 1.0%; quintile 5: 1.3%) as well as case volume and MTL30 (quintile 1: 5.3%; quintile 5: 5.3%) could be demonstrated. Also in OAR there was no significant relationship between case volume and hospital mortality (quintile 1: 5.8%, quintile 5: 3.5%; p = 0.505) and case volume and MTL30 (quintile 1: 16.4%, quintile 5: 12.2%, p = 0.110). With a hospital mortality rate of 7.2% (5-10%) the MTL30 for OAR was 17.6%. In both EVAR and OAR, the length of stay correlated significantly with hospital mortality and MTL30. DISCUSSION: A clear relationship between hospital case volume and hospital mortality could not be shown in the AAA registry of the DIGG. The same was true for the MTL30. It remains to be seen whether the MTL30 offers an additional benefit compared to the recording of hospital mortality and inpatient length of stay as a quality parameter.


Asunto(s)
Aneurisma de la Aorta Abdominal , Implantación de Prótesis Vascular , Procedimientos Endovasculares , Aneurisma de la Aorta Abdominal/cirugía , Mortalidad Hospitalaria , Humanos , Indicadores de Calidad de la Atención de Salud , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento
3.
Hamostaseologie ; 24(3): 151-6, 2004 Aug.
Artículo en Alemán | MEDLINE | ID: mdl-15314698

RESUMEN

A screening program for infrarenal abdominal aortic aneurysm (AAA) has limited cost-effectiveness. Yet, screening of the subpopulation of smoking men aged 60-75 years, or men and smoking women with a family history of vascular diseases or other cardio-vascular co-morbidity is cost-effective and has been demonstrated. It is suited to halve the increasing mortality of AAA. Elective repair of AAA is justified at diameters larger than 5.5 cm for men, but uncertain for women. However, aortic diameters between 4.5 and 5 cm in women probably necessitate an invasive approach. Surveillance of patients who still not meet these criteria should not only include the absolute diameter of the aneurysm, but direct individuals with aneurysms at an annual expansion rate of more than 0.5 cm to elective repair.


Asunto(s)
Aneurisma de la Aorta Abdominal/epidemiología , Animales , Aneurisma de la Aorta Abdominal/diagnóstico , Aneurisma de la Aorta Abdominal/mortalidad , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Caracteres Sexuales , Fumar
4.
Eur J Vasc Endovasc Surg ; 27(1): 45-50, 2004 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-14652836

RESUMEN

OBJECTIVES: Even though endovascular aneurysm repair (EVAR) creates a closed chamber except for patent branches, the intra-sac pressure is never zero. This study was designed to investigate whether, and to what extent, aneurysm wall compliance influences intra-sac pressure. DESIGN: In vitro experimental study. METHODS: Aneurysm models with six and 12 latex layers were produced, resulting in elastic and stiff circumferential compliance (3.5 +/- 0.5 and 0.9 +/- 0.3%/100 mmHg, respectively). The models with an 18 mm internal neck and maximum aneurysm diameter of 60 mm were inserted into an in vitro circulation system. The systemic mean pressure (SPmean) was varied from 50 to 120 mmHg. After the aneurysm was excluded with a knitted polyethylene graft, aneurysm sac mean pressure (ASPmean) and aneurysm sac pulse pressure (ASPpulse) were measured. Data are presented as mean +/- SD. Statistics were performed using repeated measurements of variance; p<0.05 was considered significant. RESULTS: In the model EVAR created a closed chamber without endoleak, but with an aneurysm sac pressure related to wall compliance. In the elastic aneurysm model with six latex coats the aneurysm sac mean pressure (ASPmean) and the aneurysm sac pulse pressure (ASPpulse) at all systemic pressures were significantly lower than they were in the stiffer model with 12 latex coats (p<0.05). At a SPmean of 90 mmHg, the ASPmean was 21.0 +/- 0.9 mmHg (six latex coats) and 26.0 +/- 0.2 mmHg (12 latex coats) (p<0.05), the ASPpulse was 5.7 +/- 0.2 mmHg (six latex coats) and 8.8 +/- 0.3 mmHg (12 latex coats) (p<0.05). CONCLUSIONS: This in vitro model demonstrated that the aneurysm sac mean pressure (ASPmean) and the aneurysm sac pulse pressure (ASPpulse) were significantly influenced by the compliance of the aneurysm wall. These data highlight the need for further studies regarding endotension.


Asunto(s)
Aneurisma de la Aorta Abdominal/fisiopatología , Aneurisma de la Aorta Abdominal/cirugía , Implantación de Prótesis Vascular , Adaptabilidad , Látex , Modelos Biológicos , Estrés Mecánico
5.
Hamostaseologie ; 23(2): 90-6, 2003 May.
Artículo en Alemán | MEDLINE | ID: mdl-12736705

RESUMEN

Increasingly, endovascular therapy of the superficial femoral artery (SFA) is performed using stent technology. Not only short stenoses, but also longer lesions are receiving primary endovascular treatment, although several randomized studies have shown that stenting the SFA does not improve the prognosis after PTA of lesions of this size. Rather, the stent is indicated as a secondary measure to preserve the PTA-result should complications such as a dissection occur. New technical developments such as nitinol stents, sirolimus or PTFE coated stents offer the prospect of treating more complex SFA lesions (TASC Typ C). However, randomized studies reporting long term results with such stents have yet to be published and any cost-benefit analysis of stent therapy is questionable due to lack of pertinent data. Adjunctive techniques such as laser or brachytherapy have not shown convincing improvement of endovascular SFA therapy. Compound intervention carries the risk of injury to the branching profunda or the popliteal segment, which can transform an otherwise relatively harmless SFA occlusion into a lesion which may endanger the extremity. Furthermore, increasing complexity of the SFA lesion or lesions in diabetic patients result in markedly worse results when stented, in contrast to treatment employing bypass surgery. Applying evidence based criteria to treatment recommendation shows that primary stent-PTA of the SFA is, in most cases, medically and economically unjustifiable.


Asunto(s)
Arteriopatías Oclusivas/cirugía , Arteria Femoral/cirugía , Stents , Arteria Femoral/anatomía & histología , Arteria Femoral/diagnóstico por imagen , Cirugía General , Humanos , Radiografía
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA