[Study on the correlation between Chinese medicine syndrome and the intestinal mucosal manifestations of 137 patients with active ulcerative colitis].

OBJECTIVE: To observe the distribution features of Chinese medicine syndrome (CMS) in 137 patients with active ulcerative colitis (AUC), and to analyze the correlation between the intestinal mucosal manifestations and CMS. METHODS: Totally 137 AUC patients were syndrome typed. The intestinal mucosal manifestations were observed under endoscope, thus analyzing the correlation between the intestinal mucosal manifestations and CMS. RESULTS: In the distribution of main syndromes, the case numbers were sequenced as the damp heat of Dachang syndrome > the yang deficiency of Pi-Shen syndrome > the Gan-depression and Pi-deficiency syndrome > the deficiency of Pi-qi syndrome > the blood stasis of the intestine meridian syndrome > the deficiency of blood and yin syndrome. The frequency of intestinal mucosal manifestations more than 50% covered mucosal damage, abnormal mucosa membrane color, congestion, edema, erosion, ulcer, pus tongue fur, and obscure or disappeared blood vessels. The edema, erosion, and ulcer occurred more in the damp-heat of Dachang syndrome, followed by the yang deficiency of Pi-Shen syndrome and the Gan-depression and Pi-deficiency syndrome (P < 0.05, P < 0.01). Polypi, abnormal enterokinesia, grainy occurred more in the damp-heat of Dachang syndrome and the Gan-depression and Pi-deficiency syndrome (P = 0.010). Shallower plica or disappeared sacculations of colon occurred more in the yang deficiency of Pi-Shen syndrome and the damp-heat of Dachang syndrome (P = 0.002). The mucosa bridge occurred more in the yang deficiency of Pi-Shen syndrome and Gan-depression and Pi-deficiency syndrome (P = 0.280). Fragility or contact bleeding occurred more in the damp-heat of Dachang syndrome, the deficiency of Pi-qi syndrome, and Gan-depression and Pi-deficiency syndrome (P = 0. 045). Pale blood of the intestinal hemorrhage occurred more in the deficiency of Pi-qi syndrome while dark blood occurred more in the damp-heat of Dachang syndrome (P = 0.017). Pus tongue fur occurred more in the damp-heat of Dachang syndrome, the yang deficiency of Pi-Shen syndrome, and the Gan-depression and Pi-deficiency syndrome. White pus tongue fur occurred more in the yang deficiency of Pi-Shen syndrome while yellow pus tongue fur occurred more in the damp-heat of Dachang syndrome (P < 0.001). Mucus occurred more in the yang deficiency of Pi-Shen syndrome, the Gan-depression and Pi-deficiency syndrome, and the deficiency of Pi-qi syndrome (P = 0.012). Narrow enteric cavity or intestinal canal fibrosis, lead pipe like manifestations occurred more in the blood stasis of the intestine meridian syndrome (P = 0.001). Atrophic mucosa occurred more in the blood stasis of the intestine meridian syndrome and the deficiency of blood and yin syndrome (P < 0.001). CONCLUSIONS: The intestinal mucosal manifestations of AUC showed certain laws in CMS. The microscopic differences could verify macroscopic CMS to some extent.

[The interior-exterior correlation between fei and dachang from the lung function injury in ulcerative colitis patients].

OBJECTIVE: To observe the probability of the lung injury and the features of the lung function injury in ulcerative colitis patients, and to preliminarily study the correlation with its severity, and further to analyze the interior-exterior correlation between Fei and Dachang. METHODS: Seventy patients with UC were assigned to the mild group and the moderate-severe group by the severity, 35 cases in each group. Another thirty healthy subjects were recruited as the control group. Relative indices of the lung function in each group were observed and compared. RESULTS: The lung injury occurred in 67. 14% of the UC patients (47 cases). Forced expiratory volume at 1st s/forced volume capacity (FEV1/FVC), maximal expiratory flow in 75% vital capacity (FEF75), total lung capacity (TLC), diffusion capacity for carbon monoxide of lung (DLCO), and diffusion capacity for carbon monoxide of lung/alveolar ventilation (DLCO/VA) were lower compared with those of the control group, showing statistical significance (P < 0.05). The ratio of residual volume/total lung capacity (RV/TLC) was lower in the mild group than in the moderate-severe group (P < 0.01). The DLCO was higher in the mild group than in the moderate-severe group (P < 0.05). CONCLUSIONS: Most UC patients were complicated with the lung function injury, mainly featured as middle and small airway obstruction and decreasing diffusing capacity. Besides, along with the aggravation of the disease, the decreasing diffusing capacity and increasing RV/TLC occurred. They provided objective reliance for Fei and Dachang interior-exteriorly correlated.