1.
Mol Cell Biochem
; 183(1-2): 169-73, 1998 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-9655193
RESUMEN
Hexadecylphosphocholine (HePC) is known as antitumor agent but the mechanism has not yet been understood. In rat liver mitochondria its effect on phospholipid transformation has been studied by quantitative HPTLC and phosphorus determination. From the results it can be concluded that HePC influences the activities of phospholipase A2, phospholipase C, phospholipase D, and lysophospholipase A. The phospholipid transformation as well as the influence of HePC are affected by exogenous calcium ions. In the presence of calcium HePC has been found to inhibit enzyme activities, whereas in the absence of exogenous calcium ions enzymatic phospholipid transformations are activated or inhibited depending on HePC concentrations.
Asunto(s)
Mitocondrias Hepáticas/efectos de los fármacos , Mitocondrias Hepáticas/metabolismo , Fosfolípidos/metabolismo , Fosforilcolina/análogos & derivados , Animales , Calcio/farmacología , Cromatografía en Capa Delgada/métodos , Relación Dosis-Respuesta a Droga , Mitocondrias Hepáticas/química , Fosforilcolina/farmacología , Ratas , Factores de Tiempo
2.
Pediatr Akus Ginekol
; 5: 61-2, 1972 Oct.
Artículo
en Ucraniano
| MEDLINE
| ID: mdl-4633307
3.
Pediatr Akus Ginekol
; 4: 60, 1969.
Artículo
en Ruso
| MEDLINE
| ID: mdl-5364492