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1.
J Inorg Biochem ; 257: 112585, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38718498

RESUMEN

Ruthenium complexes are one of the most promising anticancer drugs and ferroptosis is a novel form of regulated cell death, the study on the effect of Ru complexes on ferroptosis is helpful to find more effective antitumor drugs. Here, the synthesis and characterization of two Ru complexes containing 8-hydroxylquinoline and triphenylphosphine as ligands, [Ru(L1) (PPh3)2Cl2] (Ru-1), [Ru(L2) (PPh3)2Cl2] (Ru-2), were reported. Complexes Ru-1 âˆ¼ Ru-2 showed good anticancer activity in Hep-G2 cells. Researches indicated that complexes Ru-1 âˆ¼ Ru-2 could be enriched and appear as red fluorescence in the mitochondria, arouse dysfunction of mitochondria, induce the accumulation of reactive oxygen species (ROS) and lipid peroxidation (LPO), while the morphology of nuclei and cell apoptosis had no significant change. Further experiments proved that GPX4 and Ferritin were down-regulated, which eventually triggered ferroptosis in Hep-G2 cells. Remarkably, Ru-1 showed high inhibitory activity against xenograft tumor growth in vivo (TGIR = 49%). This study shows that the complex Ru-1 could act as a novel drug candidate by triggering cell ferroptosis.


Asunto(s)
Antineoplásicos , Complejos de Coordinación , Ferroptosis , Mitocondrias , Rutenio , Ferroptosis/efectos de los fármacos , Humanos , Antineoplásicos/farmacología , Antineoplásicos/química , Antineoplásicos/síntesis química , Animales , Rutenio/química , Complejos de Coordinación/farmacología , Complejos de Coordinación/química , Complejos de Coordinación/síntesis química , Mitocondrias/efectos de los fármacos , Mitocondrias/metabolismo , Ratones , Células Hep G2 , Especies Reactivas de Oxígeno/metabolismo , Compuestos Organofosforados/química , Compuestos Organofosforados/farmacología , Ratones Desnudos , Ensayos Antitumor por Modelo de Xenoinjerto , Oxiquinolina/química , Oxiquinolina/farmacología , Peroxidación de Lípido/efectos de los fármacos , Ratones Endogámicos BALB C
2.
J Mater Chem B ; 8(15): 3150, 2020 Apr 21.
Artículo en Inglés | MEDLINE | ID: mdl-32215436

RESUMEN

Correction for 'An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma' by Han Yang et al., J. Mater. Chem. B, 2020, 8, 251-259.

3.
J Mater Chem B ; 8(2): 251-259, 2020 01 14.
Artículo en Inglés | MEDLINE | ID: mdl-31799596

RESUMEN

To create a more precise, efficient imaging and therapeutic strategy is a big challenge for the current treatment of hepatocellular carcinoma (HCC). Photothermal therapy (PTT) has attracted enormous attention due to its non-invasive property and precise spatial and temporal control. Here, we developed a strategy to realize superior imaging performance and treatment, utilizing an indocyanine green (ICG) and sorafenib (S) co-loaded mesoporous silica nanosystem for synergetic PTT/immuno-enhanced therapy. We proved that (ICG+S)@mSiO2 could be easily endocytosed by H22 cells, carried out outstanding real-time fluorescence imaging, and enhanced cytotoxicity abilities by near-infrared radiation (NIR) in vitro. Moreover, (ICG+S)@mSiO2 also had excellent fluorescence imaging ability, displayed a remarkable photothermal tumor killing effect and immune enhancement capability under 808 nm irradiation in an H22 tumor-bearing mice model, without apparent adverse effects in other organs. This study provides a new strategy for the development of a PTT/immuno-enhanced synergistic theranostic nanosystem of HCC.


Asunto(s)
Carcinoma Hepatocelular/tratamiento farmacológico , Inmunoterapia/métodos , Neoplasias Hepáticas/tratamiento farmacológico , Nanopartículas/uso terapéutico , Fototerapia/métodos , Nanomedicina Teranóstica/métodos , Animales , Antineoplásicos/administración & dosificación , Línea Celular Tumoral , Femenino , Verde de Indocianina , Ratones , Ratones Endogámicos C57BL , Dióxido de Silicio , Sorafenib/administración & dosificación
4.
Mater Sci Eng C Mater Biol Appl ; 80: 102-109, 2017 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-28866143

RESUMEN

Photothermal therapy (PTT) has drawn tremendous attention because of its high therapeutic efficiency in targeting cells while minimizing the damage to normal tissues and organs. Tungsten oxide (W18O49, WO) plays a pivotal role in PTT development and its use in PTT systems has been extensively studied. However, it is difficult to control morphology of WO through conventional hydrothermal method. Which make its related researches have been limited up to now. In this study, we describe the construction and effects on tumor of a novel nanoplatform based on WO and indocyanine green (ICG) loaded in mesoporous silica nanoparticles (MSN) for dual-modal PTT and near-infrared imaging. (WO+ICG)@MSN could efficiently control WO shape without the need of surface modification due to its water-soluble of MSN. (WO+ICG)@MSN produced a PTT synergistic effect under irradiation of a single 808nm near-infrared (NIR) laser. Notably, an enhanced lethal effect of the 808nm laser triggering dual-modal therapy on B16 tumor cells was observed. The in vivo animal experiments showed that (WO+ICG)@MSN induced an effective solid tumor reduction under 808nm NIR light irradiation, revealing the potential of these nanocomposites as a NIR-mediated dual-modal therapeutic platform for cancer treatment.


Asunto(s)
Verde de Indocianina/química , Animales , Fluorescencia , Nanopartículas , Fototerapia , Dióxido de Silicio
5.
ACS Appl Mater Interfaces ; 8(33): 21603-11, 2016 Aug 24.
Artículo en Inglés | MEDLINE | ID: mdl-27491888

RESUMEN

Optical imaging-guidance of indocyanine green (ICG) for photothermal therapy (PTT) has great latent capacity in cancer therapy. However, the conventional optical image-guidance mode has caused strong tissue autofluorescence of the living tissue, which leads to the accurate infrared light irradiation cannot be conducted. In this article, ICG and persistent luminescence phosphors (PLPs) coloaded mesoporous silica nanocarriers ((ICG+PLPs)@mSiO2) were first designed and prepared for persistent luminescent imaging-guided PTT. The (ICG+PLPs)@mSiO2 nanocarriers could significantly improve signal-to-noise ratio during luminescence imaging-guided PTT, making the PLP promising for improving the accuracy of the tumor site for photothermal therapy in vivo. This paper is likely to develop a new way for accurately regulating cancer cell death based on luminescence imaging-guided PTT selectively triggered by near-infrared (NIR)-remote.


Asunto(s)
Luminiscencia , Verde de Indocianina , Nanoestructuras , Fototerapia , Dióxido de Silicio
6.
J Drug Target ; 18(6): 420-9, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19954414

RESUMEN

The blood-spinal cord barrier (BSCB) prevents many macromolecular agents from passing through to reach sites of injury in the spinal cord. This study evaluated the ability of a novel multifunctional liposome modified with polyethylene glycol (PEG) and transactivating-transduction protein (TAT) containing an iron core to cross the BSCB using a rat model of spinal cord injury. Rats were examined daily for a period of three days after spinal cord injury and injection of either the multifunctional modified liposome or control formulations using a 3.0 T magnetic resonance imaging spectrometer. A low signal was observed in the T2-weighted images. Prussian blue staining and flame atomic absorption spectrophotometry revealed that significantly more iron accumulated around the lesion site in the experimental group than the control groups (P < 0.05). The findings from this study suggest that this multifunctional liposome carrier can cross the BSCB to accumulate around the lesion site.


Asunto(s)
Sistemas de Liberación de Medicamentos/métodos , Productos del Gen tat/química , Fragmentos de Péptidos/química , Polietilenglicoles/química , Traumatismos de la Médula Espinal/sangre , Médula Espinal/irrigación sanguínea , Animales , Quitosano/administración & dosificación , Quitosano/análogos & derivados , Quitosano/química , Quitosano/farmacocinética , Colesterol/administración & dosificación , Colesterol/química , Colesterol/farmacocinética , Modelos Animales de Enfermedad , Productos del Gen tat/administración & dosificación , Productos del Gen tat/farmacocinética , Hierro/química , Liposomas , Imagen por Resonancia Magnética , Magnetismo , Microscopía Electrónica de Transmisión , Nanopartículas , Tamaño de la Partícula , Fragmentos de Péptidos/administración & dosificación , Fragmentos de Péptidos/farmacocinética , Péptidos/administración & dosificación , Péptidos/química , Péptidos/farmacocinética , Polietilenglicoles/administración & dosificación , Polietilenglicoles/farmacocinética , Ratas , Espectrofotometría Atómica , Médula Espinal/metabolismo , Médula Espinal/ultraestructura , Traumatismos de la Médula Espinal/tratamiento farmacológico , Traumatismos de la Médula Espinal/metabolismo , Traumatismos de la Médula Espinal/patología , Propiedades de Superficie
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