Crizotinib combined with bronchoscopic interventional treatment in ALK-positive inflammatory myofibroblastic tumor of left main stem bronchus: a case report.

BACKGROUND: Inflammatory myofibroblastic tumor (IMT), also known as an inflammatory pseudotumor, is a unique type of intermediate soft tissue tumor that commonly occurred in the lung. Its unclear etiology and cellular activity brought about the confusion not only in naming of it, but also in diagnosis and treatment. CASE PRESENTATION: We reported the case of an 18-year-old male student who suffered from shortness of breath, chest tightness and chest pain. Chest computed tomography scan showed a spherical neoplasm blocking left main stem bronchus. After fiberoptic bronchoscopy procedure, the results of histopathological and immunohistochemical analysis indicated an IMT. The targeted next generation sequencing based genomic profiling of the tumor using formalin-fixed and paraffin embedded tissue was performed and a EML4-ALK fusion was detected. The patient began to receive Crizotinib, a ALK tyrosine kinase inhibitor, at a dose of 250 mg twice daily orally. The patient has recovered well after the operation, and no recurrence or metastasis has been found after 12 months' follow-up. CONCLUSION: By means of the diagnosis and treatment of this case, the characteristics and therapies of IMT are illustrated. In addition, it also provides a reference for the therapeutic strategy of IMT in the future.

Air pollution prevention in central China: Effects on particulate-bound PAHs from 2010 to 2018.

Long-term trends in particulate-bound polycyclic aromatic hydrocarbon (PAH) concentrations in air in Zhengzhou (a severely polluted city in central China) between 2010 and 2018 were studied to assess the effectiveness of an air pollution prevention and control action plan (APPCAP) implemented in 2013. The PM2.5, sum of 16 PAHs (Σ16 PAHs), benzo[a]pyrene (BaP), and BaP toxic equivalent concentrations were high before 2013 but 41%, 77%, 77%, and 78% lower, respectively, after the APPCAP. The maximum daily Σ16 PAHs concentration between 2014 and 2018 was 338 ng/m3, 65% lower than the maximum of 961 ng/m3 between 2010 and 2013. The ratio between the Σ16 PAHs concentrations in winter and summer decreased over time and was 8.0 in 2011 and 1.5 in 2017. The most abundant PAH was benzo[b]fluoranthene, for which the 9-year mean concentration was 14 ± 21 ng/m3 (15% of the Σ16 PAHs concentration). The mean benzo[b]fluoranthene concentration decreased from 28 ± 27 ng/m3 before to 5 ± 4 ng/m3 after the APPCAP (an 83% decrease). The mean daily BaP concentrations were 0.1-62.8 ng/m3, and >56% exceeded the daily standard limit of 2.5 ng/m3 for air. The BaP concentration decreased from 10 ± 8 ng/m3 before to 2 ± 2 ng/m3 after the APPCAP (a 77% decrease). Diagnostic ratios and positive matrix factorization model results indicated that coal combustion and vehicle exhausts were important sources of PAHs throughout the study period, contributing >70% of the Σ16 PAHs concentrations. The APPCAP increased the relative contribution of vehicle exhausts from 29% to 35% but decreased the Σ16 PAHs concentration attributed to vehicle exhausts from 48 to 12 ng/m3. The PAH concentration attributed to vehicle exhausts decreased by 79% even though vehicle numbers strongly increased, indicating that pollution caused by vehicles was controlled well. The relative contribution of coal combustion remained stable but the PAH concentration attributed to coal combustion decreased from 68 ng/m3 before to 13 ng/m3 after the APPCAP. Vehicles made dominant contributions to the incremental lifetime cancer risk (ILCRs) before and after the APPCAP even though the APPCAP decreased the ILCRs by 78%. Coal combustion was the dominant source of PAHs but contributed only 12-15% of the ILCRs. The APPCAP decreased PAH emissions and changed the contributions of different sources of PAHs, and thus strongly affected the overall toxicity of PAHs to humans.

Chemical composition and anti-inflammatory activities of Castanopsis honey.

Castanopsis is diffusely spread in tropical and subtropical regions and is an important nectar source plant in China. The Castanopsis honey (CH) is characterized by its bitter taste. However, its composition and functions remain unclear. In this study, the physicochemical parameters, chemical composition, and antioxidant capacity of CH were comprehensively investigated, with the anti-inflammatory effects of the Castanopsis honey extract (CHE) evaluated based on the RAW 264.7 cell inflammatory model. The results revealed a high level of quality in CH based on the quality standards. Among a total of 84 compounds identified in CH, 5 high response compounds and 29 phenols were further quantified by UPLC-Q/TOF-MS. The high content of phenylethylamine (117.58 ± 64.81 mg kg-1) was identified as a potential marker of CH. Furthermore, the CH showed evident antioxidant activities, and the anti-inflammatory activities of CHE were observed to inhibit the release of nitric oxide (NO) and reduce the content of tumor necrosis factor alpha (TNF-α) and improve the content of interleukin-10 (IL-10) by regulating the NF-κB pathway. Our study indicates that CH has sound physicochemical properties and biological activities with a high level of quality, providing strong experimental evidence to support the further economic and agricultural development and application of CH.

Male occult breast cancer with axillary lymph node metastasis as the first manifestation: A case report and literature review.

RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes. Immunohistochemical (IHC) staining was negative for estrogen receptor (ER), progesterone receptor (PR), cytokeratin (CK)20 and thyroid transcription factor-1 (TTF-1), positive for CK7, gross cystic disease fluid protein-15 (GCDFP-15), epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA), and suspicious positive for human epidermal receptor-2 (Her-2). On basis of IHC markers, particularly such as CK7, CK20 and GCDFP-15, and eliminating other malignancies, male OBC was identified in spite of negativity for hormone receptors. INTERVENTIONS: The patient underwent left axillary lymph node dissection (ALND) but not mastectomy. After the surgery, the patient subsequently underwent chemotherapy and radiotherapy. OUTCOMES: The patient is currently being followed up without any signs of recurrence. LESSONS: Carefully imaging examination and pathological analysis were particularly essential in the diagnosis of male OBC. The guidelines for managing male OBC default to those of female OBC and male breast cancer.