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1.
Molecules ; 28(5)2023 Feb 26.
Artículo en Inglés | MEDLINE | ID: mdl-36903419

RESUMEN

The acidic extracellular microenvironment has become an effective target for diagnosing and treating tumors. A pH (low) insertion peptide (pHLIP) is a kind of peptide that can spontaneously fold into a transmembrane helix in an acidic microenvironment, and then insert into and cross the cell membrane for material transfer. The characteristics of the acidic tumor microenvironment provide a new method for pH-targeted molecular imaging and tumor-targeted therapy. As research has increased, the role of pHLIP as an imaging agent carrier in the field of tumor theranostics has become increasingly prominent. In this paper, we describe the current applications of pHLIP-anchored imaging agents for tumor diagnosis and treatment in terms of different molecular imaging methods, including magnetic resonance T1 imaging, magnetic resonance T2 imaging, SPECT/PET, fluorescence imaging, and photoacoustic imaging. Additionally, we discuss relevant challenges and future development prospects.


Asunto(s)
Neoplasias , Medicina de Precisión , Humanos , Péptidos/química , Imagen por Resonancia Magnética , Concentración de Iones de Hidrógeno , Microambiente Tumoral
2.
Chin J Nat Med ; 15(8): 576-583, 2017 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-28939020

RESUMEN

Tripolinolate A (TLA) is recently identified as a new compound from a halophyte plant Tripolium vulgare and has been shown to have significant in vitro activity against the proliferation of colorectal cancer and glioma cells. This study was designed to further investigate the effects of TLA on the proliferation of human normal cells, and the apoptosis and cell cycle in colorectal cancer cells, and the growth of tumors in the colorectal cancer-bearing animals. The data obtained from this study demonstrated that: 1) TLA had much less cytotoxicity in the human normal cells than the colorectal cancer cells; 2) TLA remarkably induced apoptosis in the human colorectal cancer cells and blocked cell cycle at G2/M phase, and 3) TLA had significant anti-colorectal cancer activity in the tumor-bearing animals.


Asunto(s)
Antineoplásicos Fitogénicos/administración & dosificación , Asteraceae/química , Neoplasias Colorrectales/tratamiento farmacológico , Medicamentos Herbarios Chinos/administración & dosificación , Fenoles/administración & dosificación , Animales , Antineoplásicos Fitogénicos/química , Apoptosis/efectos de los fármacos , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Neoplasias Colorrectales/fisiopatología , Medicamentos Herbarios Chinos/química , Ésteres/administración & dosificación , Ésteres/química , Fase G2/efectos de los fármacos , Humanos , Masculino , Ratones , Ratones Endogámicos BALB C , Fenoles/química
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