RESUMEN
The kinetics of degradation and sustained cancer drugs (paclitaxel (PT) and prodigiosin (PG)) release are presented for minirods (each with diameter of ~5 and ~6 mm thick). Drug release and degradation mechanisms were studied from solvent-casted cancer drug-based minirods under in vitro conditions in phosphate buffer solution (PBS) at a pH of 7.4. The immersed minirods were mechanically agitated at 60 revolutions per minute (rpm) under incubation at 37 °C throughout the period of the study. The kinetics of drug release was studied using ultraviolet visible spectrometry (UV-Vis). This was used to determine the amount of drug released at 535 nm for poly(lactic-co-glycolic acid) loaded with prodigiosin (PLGA-PG) samples, and at 210 nm, for paclitaxel-loaded samples (PLGA-PT). The degradation characteristics of PLGA-PG and PLGA-PT are elucidated using optical microscope as well as scanning electron microscope (SEM). Statistical analysis of drug release and degradation mechanisms of PLGA-based minirods were performed. The implications of the results are discussed for potential applications in implantable/degradable structures for multi-pulse cancer drug delivery.
Asunto(s)
Antineoplásicos/farmacología , Preparaciones de Acción Retardada/química , Portadores de Fármacos , Ácido Láctico/química , Neoplasias/tratamiento farmacológico , Ácido Poliglicólico/química , Materiales Biocompatibles/química , Difusión , Liberación de Fármacos , Humanos , Concentración de Iones de Hidrógeno , Hidrólisis , Cinética , Microscopía Electrónica de Rastreo , Paclitaxel/administración & dosificación , Tamaño de la Partícula , Copolímero de Ácido Poliláctico-Ácido Poliglicólico , Polímeros/química , Prodigiosina/administración & dosificación , Espectrofotometría Ultravioleta , TemperaturaRESUMEN
Numerical simulations were used to study the transmittances (Ts) of ZnO/Al/ZnO (ZAZ) films with Al thicknesses between â¼1 and 40 nm. The simulations are validated using previously reported experimental results. Multilayers with Al thicknesses between â¼1 and 10 nm are shown to have average Ts between â¼75% and 90%, which decreased farther to â¼63 and 41% for the Al layer thicknesses of 20 and 40 nm, respectively. Variations in the ZnO thickness between â¼10 and 100 nm are shown to have little effect on the optical properties of the model multilayers for a given Al thickness. The reliability of the numerical simulations is tested by comparing them with experimental measurements on films produced using similar interlayer thicknesses. These are also shown to be comparable to the performance characteristics of indium tin oxide (ITO) anodes that are used currently in organic solar cells (OSCs) and organic light emitting diodes (OLEDs).