Asunto(s)
Sarcoma de Kaposi/complicaciones , Sarcoma de Kaposi/diagnóstico , Síndrome de Sézary/complicaciones , Síndrome de Sézary/diagnóstico , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Persona de Mediana Edad , Sarcoma de Kaposi/patología , Síndrome de Sézary/patología , Piel/patología , Neoplasias Cutáneas/patologíaRESUMEN
IMPORTANCE: Lichen sclerosus (LS) is an uncommon chronic inflammatory disease that most commonly affects anogenital skin of postmenopausal women. It typically manifests as atrophic white plaques, which may be accompanied by purpura or fissuring. Rarely, LS has been observed to affect mucosal tissues in the mouth and the penile urethra. It is generally taught that LS does not affect the vagina, unlike lichen planus. To our knowledge, only one case report of LS with vaginal involvement exists in the literature. OBSERVATIONS: Two cases of severe vulvar LS with vaginal involvement are reported. Both cases exhibited characteristic features of LS on vaginal biopsy, and both patients were followed up clinically without further treatment of the vagina. CONCLUSIONS AND RELEVANCE: Vaginal LS may be more common than previously thought and may be underdiagnosed. Patients with more severe disease or with significant vaginal atrophy may be more likely to have involvement of the vagina. In addition, patients with pelvic organ laxity may be at increased risk if their vaginal walls are chronically exposed because of prolapse. Physicians managing patients with vulvar LS should be aware of the possibility of vaginal involvement so that vaginal lesions may be diagnosed and followed up appropriately.
Asunto(s)
Enfermedades Vaginales/patología , Liquen Escleroso Vulvar/patología , Anciano , Biopsia , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Índice de Severidad de la Enfermedad , Enfermedades Vaginales/diagnóstico , Enfermedades Vaginales/tratamiento farmacológico , Liquen Escleroso Vulvar/diagnóstico , Liquen Escleroso Vulvar/tratamiento farmacológicoRESUMEN
BACKGROUND: The lack of well-established diagnostic criteria for pigmented solar (actinic) keratosis (PSK) along with its poorly understood etiopathogenesis has contributed to underrecognition. OBJECTIVE: The clinical, dermatoscopic, and histopathologic features of PSK and the cause of the pigmentation are elucidated. METHODS: In all, 167 histologic specimens, 22 clinical images, and 17 dermatoscopic images of PSK were reviewed. In 38 cases, Melan-A-stained sections were available for analysis. RESULTS: The majority of the lesions were located on the head and neck (84%). A separate pigmented lesion was adjacent to or admixed within PSK in 138 (83%) of the cases indicating that PSK represents a collision between a nonpigmented solar keratosis and a pigmented lesion. Solar lentigo (72%) was the most commonly associated pigmented lesion followed by seborrheic keratosis and melanoma. PSK was suspected clinically in 17% of the cases. There were no significant differences in the quality and quantity of the melanocytes between pigmented and nonpigmented solar keratosis. LIMITATIONS: This was a single-center retrospective study. The sample sizes were small for the clinical and dermatoscopic images and Melan-A stains. CONCLUSION: In the majority of the cases, a collision between a nonpigmented solar keratosis and a separate coexistent pigmented lesion, primarily a solar lentigo, accounts for the pigmentation in PSK rather than from any fundamental changes in the quantity or quality of the melanocytes. The collision phenomenon accounts for the spectrum of the clinical and dermatoscopic features observed in PSK and its underrecognition.