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1.
Sensors (Basel) ; 24(14)2024 Jul 20.
Artículo en Inglés | MEDLINE | ID: mdl-39066120

RESUMEN

The next generation phased array radio telescopes, such as the Square Kilometre Array (SKA) low frequency aperture array, suffer from RF interference (RFI) because of the large field of view of antenna element. The classical station beamformer used in SKA-low is resource efficient but cannot deal with the unknown sidelobe RFI. A real-time adaptive beamforming strategy is proposed for SKA-low station, which trades the capability of adaptive RFI nulling at an acceptably cost, it doesn't require hardware redesign but only modifies the firmware accordingly. The proposed strategy uses a Parallel Least Mean Square (PLMS) algorithm, which has a computational complexity of 4N+2 and can be performed in parallel. Beam pattern and output SINR simulation results show deeply nulling performance to sidelobe RFI, as well as good mainlobe response similar to the classical beamformer. The convergence performance depends on the signal-and-interference environments and step size, wherein too large a step size leads to a non-optimal output SINR and too small a step size leads to slow convergence speed. FPGA implementation demonstrations are implemented and tested on a NI FPGA module, and test results demonstrate good real-time performance and low slice resource consumption.

2.
Biomed Eng Lett ; 14(3): 571-582, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38645597

RESUMEN

Intracardiac echocardiography (ICE) enables cardiac imaging with a wide field of view, deep imaging depth, and high frame rate during surgery. However, strong sidelobe and grating lobe artifacts created by the ultra-compact transducer degrade its image quality, making diagnosis and monitoring of treatment difficult. Conventionally, aperture apodization algorithms are often used to suppress sidelobe and grating lobe artifacts at the expense of lateral resolution, which is undesirable in ICE. In this study, we present comparative results of the beamforming methods specifically in ICE application. We demonstrate and compare five nonlinear beamforming algorithms in ICE: nonlinear pth root delay and sum (NL-p-DAS), nonlinear pth root spectral magnitude scaling (NL-p-SMS), delay-and-sum with coherence factors (DAS + SCF), delay and sum with apodization (DAS + apodization) and delay and sum (DAS). Phantom and ex-vivo experiment compare the performance of each algorithm in static and dynamic conditions. DAS + SCF shows the best lateral resolution, and all four algorithms improve the image contrast and sidelobe suppression over conventional DAS. NL-p-SMS stands out for the best axial resolution and suppression of grating lobe artifacts. For motion tracking, NL-p-SMS shows better temporal resolution than other methods. Overall, all the beamforming algorithms other than DAS showed improved image quality. Among them, NL-p-SMS, which has a high temporal resolution, showed the potential for providing more accurate information regards movement tracking. Supplementary Information: The online version contains supplementary material available at 10.1007/s13534-024-00352-9.

3.
Cancers (Basel) ; 16(7)2024 Mar 22.
Artículo en Inglés | MEDLINE | ID: mdl-38610923

RESUMEN

To develop ultrasound-guided radiotherapy, we proposed an assistant structure with embedded markers along with a novel alternative method, the Aligned Peak Response (APR) method, to alter the conventional delay-and-sum (DAS) beamformer for reconstructing ultrasound images obtained from a flexible array. We simulated imaging targets in Field-II using point target phantoms with point targets at different locations. In the experimental phantom ultrasound images, image RF data were acquired with a flexible transducer with in-house assistant structures embedded with needle targets for testing the accuracy of the APR method. The lateral full width at half maximum (FWHM) values of the objective point target (OPT) in ground truth ultrasound images, APR-delayed ultrasound images with a flat shape, and images acquired with curved transducer radii of 500 mm and 700 mm were 3.96 mm, 4.95 mm, 4.96 mm, and 4.95 mm. The corresponding axial FWHM values were 1.52 mm, 4.08 mm, 5.84 mm, and 5.92 mm, respectively. These results demonstrate that the proposed assistant structure and the APR method have the potential to construct accurate delay curves without external shape sensing, thereby enabling a flexible ultrasound array for tracking pancreatic tumor targets in real time for radiotherapy.

4.
Sensors (Basel) ; 24(5)2024 Feb 20.
Artículo en Inglés | MEDLINE | ID: mdl-38474901

RESUMEN

An acoustic imaging method for detecting and locating gas leaks based on a virtual ultrasonic sensor array is proposed and experimentally demonstrated. A scanning sensor array of only two sensors is used to collect the acoustic signals generated by the leakage hole. The matrix of the leakage signal is processed by the cross-power spectrum method to achieve time consistency, afterward, the location of the leakage source can be calculated by the virtual beamforming method. The influence of the number of sensors and the distance between adjacent sensors on the effect of the proposed method are compared and discussed. To verify the effectiveness and operability of the detection and localization method, several experiments were carried out. Furthermore, a series of experiments were conducted to assess the accuracy and stability of this method. The experimental results demonstrate that the proposed method based on a virtual sensor array can achieve highly accurate localization of gas leaks and performs well regarding stability.

5.
Math Biosci Eng ; 21(1): 1573-1589, 2024 Jan 02.
Artículo en Inglés | MEDLINE | ID: mdl-38303478

RESUMEN

While immersive media services represented by virtual reality (VR) are booming, They are facing fundamental challenges, i.e., soaring multimedia applications, large operation costs and scarce spectrum resources. It is difficult to simultaneously address these service challenges in a conventional radio access network (RAN) system. These problems motivated us to explore a quality-of-service (QoS)-driven resource allocation framework from VR service perspective based on the fog radio access network (F-RAN) architecture. We elaborated details of deployment on the caching allocation, dynamic base station (BS) clustering, statistical beamforming and cost strategy under the QoS constraints in the F-RAN architecture. The key solutions aimed to break through the bottleneck of the network design and to deep integrate the network-computing resources from different perspectives of cloud, network, edge, terminal and use of collaboration and integration. Accordingly, we provided a tailored algorithm to solve the corresponding formulation problem. This is the first design of VR services based on caching and statistical beamforming under the F-RAN. A case study provided to demonstrate the advantage of our proposed framework compared with existing schemes. Finally, we concluded the article and discussed possible open research problems.

6.
Quant Imaging Med Surg ; 13(7): 4603-4617, 2023 Jul 01.
Artículo en Inglés | MEDLINE | ID: mdl-37456280

RESUMEN

Background: An aberration correction algorithm has been implemented and demonstrated in an echocardiographic clinical trial using two-dimensional (2D) imaging. The method estimates and compensates arrival time errors between different sub-aperture processor (SAP) signals in a matrix array probe. Methods: Five standard views of channel data cineloops were recorded from 22 patients (11 male and 11 female) resulting in a total of 116 cineloops. The channel data were processed with and without the aberration correction algorithm, allowing for side-by-side comparison of images processed from the same channel data cineloops. Results: The aberration correction algorithm improved image quality, as quantified by a coherence metric, in all 7,380 processed frames. In a blinded and left-right-randomized side-by-side evaluation, four cardiologists (two experienced and two in training) preferred the aberration corrected cineloops in 97% of the cases. The clinicians reported that the corrected cineloops appeared sharper with better contrast and less noise. Many structures like valve leaflets, chordae, endocardium, and endocardial borders appeared narrower and more clearly defined in the aberration corrected images. An important finding is that aberration correction improves contrast between the endocardium and ventricle cavities for every processed image. The gain difference was confirmed by the cardiologists in their feedback and quantified with a median global gain difference estimate between the aberration-corrected and non-corrected images of 1.2 dB. Conclusions: The study shows the potential value of aberration correction in clinical echocardiography. Systematic improvement of images acquired with state-of-art equipment was observed both with quantitative metrics of image quality and clinician preference.

7.
Ultrasound Med Biol ; 49(8): 1709-1718, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37127527

RESUMEN

OBJECTIVE: Abundant research demonstrates that early detection of cancer leads to improved patient prognoses. By detecting cancer earlier, when tumors are in their primary stages, treatment can be applied before metastases have occurred. The presence of microcalcifications (MCs) is indicative of malignancy in the breast, i.e., 30-50% of all nonpalpable breast cancers detected using mammograms are based on identifying the presence of MCs. Therefore, improving the ability to detect MCs with modern imaging technology remains an important goal. Specifically, improving the sensitivity of ultrasound imaging techniques to detect MCs in the breast will provide an important role for the early detection and diagnosis of breast cancer. METHODS: In this work, a novel nonlinear beamforming technology for ultrasonic arrays is investigated for its ability to detect MCs. The beamforming technique, called null subtraction imaging (NSI), utilizes nulls in the beam pattern to create images using ultrasound. NSI provides improved lateral resolution, a reduction in side lobes, and an accentuation of bright singular targets. Therefore, it was hypothesized that the use of NSI would result in identification of more MCs in rat tumors having a speckle background. To test this hypothesis, rats with tumors were injected with Hydroxyapatite (HA) particles to mimic MCs. Ultrasound was used to scan the rat tumors and images were constructed using conventional delay and sum and using NSI beamforming. Three readers with experience in diagnostic ultrasound imaging examined the 1,344 images and scored the presence or absence of MCs. DISCUSSION: In all, 336 different tumor image slices were recorded and each reconstructed using NSI or conventional delay and sum with Hann apodization. In every image where one or MCs were detected in the Hann reconstructions, MCs were detected in the NSI images. In nine rat tumor images, one or more MCs were detected in the NSI images but not in the Hann images. CONCLUSIONS: Statistically, the results did support the hypothesis that NSI would increase the number of MCs detected in the rat tumors.


Asunto(s)
Calcinosis , Mamografía , Animales , Ratas , Calcinosis/diagnóstico por imagen , Procesamiento de Imagen Asistido por Computador , Ultrasonografía , Algoritmos
8.
Artículo en Inglés | MEDLINE | ID: mdl-37047882

RESUMEN

The current global roll-out of 5G infrastructure is designed to utilise millimetre wave frequencies (30-300 GHz range) at data transmission rates in the order of gigabits per second (Gbps). This frequency band will be transmitted using beamforming, a new introduction in near-field exposures. The International Commission on Non-Ionising Radiation Protection (ICNIRP) has recently updated their guidelines. We briefly examine whether the new approach of the ICNIRP is satisfactory to prevent heat damage and other adverse bio-effects once millimetre wave 5G is included, and we challenge the use of surface-only exposure assessment for local exposures greater than 6 GHz in part due to possible Brillouin precursor pulse formation. However, this is relevant whether or not Brillouin precursors occur from absorption of either 5G or future G transmissions. Many significant sources conclude there is insufficient research to assure safety even from the heat perspective. To date, there has been no published in vivo, in vitro or epidemiological research using exposures to 5G New Radio beam-formed signals.


Asunto(s)
Exposición a la Radiación , Protección Radiológica , Exposición a la Radiación/efectos adversos , Campos Electromagnéticos/efectos adversos , Ondas de Radio/efectos adversos
9.
Phys Med Biol ; 68(4)2023 02 17.
Artículo en Inglés | MEDLINE | ID: mdl-36696691

RESUMEN

Objective.While ultrasound image texture has been utilized to detect and quantify hepatic steatosis, the texture features extracted using a single (conventionally 1540 m s-1) beamforming speed of sound (SoS) failed to achieve reliable diagnostic performance. This study aimed to investigate if the texture features extracted using various beamforming SoSs can improve the accuracy of hepatic steatosis detection and quantification.Approach.Patients with suspected non-alcoholic fatty liver disease underwent liver biopsy or MRI proton density fat fraction (PDFF) as part of standard of care, were prospectively enrolled. The radio-frequency data from subjects' right and left liver lobes were collected using 6 beamforming SoSs: 1300, 1350, 1400, 1450, 1500 and 1540 m s-1and analyzed offline. The texture features, i.e. Contrast, Correlation, Energy and Homogeneity from gray-level co-occurrence matrix of normalized envelope were obtained from a region of interest in the liver parenchyma.Main results.Forty-three subjects (67.2%) were diagnosed with steatosis while 21 had no steatosis. Homogeneity showed the area under the curve (AUC) of 0.75-0.82 and 0.58-0.81 for left and right lobes, respectively with varying beamforming SoSs. The combined Homogeneity value over 1300-1540 m s-1from left and right lobes showed the AUC of 0.90 and 0.81, respectively. Furthermore, the combined Homogeneity values from left and right lobes over 1300-1540 m s-1improved the AUC to 0.94. The correlation between texture features and steatosis severity was improved by using the images from various beamforming SoSs. The combined Contrast values over 1300-1540 m s-1from left and right lobes demonstrated the highest correlation (r= 0.90) with the MRI PDFF while the combined Homogeneity values over 1300-1540 m s-1from left and right lobes showed the highest correlation with the biopsy grades (r= -0.81).Significance.The diagnostic accuracy of ultrasound texture features in detecting and quantifying hepatic steatosis was improved by combining its values extracted using various beamforming SoSs.


Asunto(s)
Enfermedad del Hígado Graso no Alcohólico , Humanos , Hígado/diagnóstico por imagen , Hígado/patología , Imagen por Resonancia Magnética/métodos , Ultrasonografía/métodos , Biopsia , Protones
10.
Ultrasound Med Biol ; 49(1): 256-268, 2023 01.
Artículo en Inglés | MEDLINE | ID: mdl-36333154

RESUMEN

Traditional breast ultrasound imaging is a low-cost, real-time and portable method to assist with breast cancer screening and diagnosis, with particular benefits for patients with dense breast tissue. We previously demonstrated that incorporating coherence-based beamforming additionally improves the distinction of fluid-filled from solid breast masses, based on qualitative image interpretation by board-certified radiologists. However, variable sensitivity (range: 0.71-1.00 when detecting fluid-filled masses) was achieved by the individual radiologist readers. Therefore, we propose two objective coherence metrics, lag-one coherence (LOC) and coherence length (CL), to quantitatively determine the content of breast masses without requiring reader assessment. Data acquired from 31 breast masses were analyzed. Ideal separation (i.e., 1.00 sensitivity and specificity) was achieved between fluid-filled and solid breast masses based on the mean or median LOC value within each mass. When separated based on mean and median CL values, the sensitivity/specificity decreased to 1.00/0.95 and 0.92/0.89, respectively. The greatest sensitivity and specificity were achieved in dense, rather than non-dense, breast tissue. These results support the introduction of an objective, reader-independent method for automated diagnoses of cystic breast masses.


Asunto(s)
Neoplasias de la Mama , Mamografía , Femenino , Humanos , Mamografía/métodos , Densidad de la Mama , Neoplasias de la Mama/diagnóstico por imagen , Ultrasonografía Mamaria/métodos , Ultrasonografía , Sensibilidad y Especificidad
11.
Appl Sci (Basel) ; 13(8)2023 Apr 02.
Artículo en Inglés | MEDLINE | ID: mdl-38711800

RESUMEN

Resolution and target detectability in ultrasound imaging are directly tied to the size of the imaging array. This is especially important for imaging at depth, such as in the detection and diagnosis of hepatocellular carcinoma and other lesions in the liver. Swept synthetic aperture (SSA) imaging has shown promise for building large effective apertures from small physical arrays using motion, but has required bulky fixtures and external motion tracking for precise positioning. In this study we present an approach that constrains the transducer motion with a simple linear sliding fixture and estimates motion from the ultrasound data itself using either speckle tracking or channel correlation. We demonstrate in simulation and phantom experiments the ability of both techniques to accurately estimate lateral transducer motion and form SSA images with improved resolution and target detectability. We observed errors under 83 µm across a 50 mm sweep in simulation and found improvements of up to 61% in resolution and up to 33% in lesion detectability experimentally even imaging through ex vivo tissue layers. This approach will increase the accessibility of SSA imaging and allow us to test its use in clinical settings.

12.
Sensors (Basel) ; 22(21)2022 Oct 25.
Artículo en Inglés | MEDLINE | ID: mdl-36365862

RESUMEN

Respiration and heartrates are important information for surgery. When the vital signs of the patient lying prone are monitored using radar installed on the back of the surgical bed, the surgeon's movements reduce the accuracy of these monitored vital signs. This study proposes a method for enhancing the monitored vital sign accuracies of a patient lying on a surgical bed using a 60 GHz frequency modulated continuous wave (FMCW) radar system with beamforming. The vital sign accuracies were enhanced by applying a fast Fourier transform (FFT) for range and beamforming which suppress the noise generated at different ranges and angles from the patient's position. The experiment was performed for a patient lying on a surgical bed with or without surgeon. Comparing a continuous-wave (CW) Doppler radar, the FMCW radar with beamforming improved almost 22 dB of signal-to-interference and noise ratio (SINR) for vital signals. More than 90% accuracy of monitoring respiration and heartrates was achieved even though the surgeon was located next to the patient as an interferer. It was analyzed using a proposed vital signal model included in the radar IF equation.


Asunto(s)
Radar , Procesamiento de Señales Asistido por Computador , Humanos , Signos Vitales , Monitoreo Fisiológico/métodos , Respiración , Frecuencia Cardíaca , Algoritmos
13.
Comput Methods Programs Biomed ; 226: 107171, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-36257199

RESUMEN

BACKGROUND AND OBJECTIVE: Recently, the Filtered Delay-Multiply-and-Sum (F-DMAS) beamformer was successfully applied to Ultrasound Imaging (UI), improving the image quality compared to the conventional data-independent Delay-and-Sum (DAS) beamformer. However, its reconstructed images lead to restricted resolution, contrast, and dark regions in the speckle. Various beamformers based on F-DMAS were proposed to mitigate these issues; some improved resolution and contrast at the expense of more dark regions; others reduced the dark points with lower contrast than the F-DMAS beamformer. This study aims to propose a novel beamformer, improving resolution and contrast while reducing dark points in the speckle. METHODS: This study proposes a modified version of the F-DMAS beamformer, using two modifications to compensate for the aforesaid trade-off. Firstly, coupled signals' Correlation Coefficient (CC) was calculated and compared to a threshold value. The multiplications were applied only to the high-correlated (those whose CC is higher than the threshold value) signals. Secondly, a new Modified Coherence Factor (MCF) was applied to the high-correlated signals. Then, these two new beamformers were combined to reach a novel beamformer entitled "Modified DMAS (MDMAS)." RESULTS: The performance of MDMAS was evaluated using simulating Point-Spread-Function, Cyst phantom, the experimental geabr dataset, and an in vivo dataset. Moreover, we evaluated the performance of the MDMAS beamformer quantitatively. Full-width-half-maximum (FWHM), contrast-ratio (CR), contrast-to-noise-ratio (CNR), speckle signal-to-noise-ratio (sSNR), and generalized-CNR (gCNR) were assessed. CONCLUSIONS: This paper modified the conventional F-DMAS beamformer by adaptively multiplying signals. Then, CF was implemented on high correlated signals (MCF) and combined with the adaptive beamformer to compensate for the poor contrast. Results highlight that the MDMAS beamformer outperforms F-DMAS in terms of resolution and contrast without compromising the speckle from the dark region artifact.


Asunto(s)
Algoritmos , Procesamiento de Imagen Asistido por Computador , Procesamiento de Imagen Asistido por Computador/métodos , Ultrasonografía/métodos , Fantasmas de Imagen , Relación Señal-Ruido
14.
J Biomed Phys Eng ; 12(4): 349-358, 2022 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-36059289

RESUMEN

Background: In body tissues, tumors generally have different speeds of sound (SOS) than normal tissues. In this respect, ultrasound computed tomography (UCT) can generate a cross-sectional SOS map as an innovative ultrasound imaging method. This technique can produce images with a resolution of millimeters and a high signal-to-noise ratio. Objective: This study aimed to improve UCT image quality without increasing breast cancer screening and diagnosis time. Material and Methods: In this analytical study, a ring-shaped UCT breast imaging system was simulated using the K-wave toolbox of MATLAB. The system has a 20 cm diameter and 256 ultrasonic piezoelectrics placed in the ring's circumference. Different beamforming techniques imaged two designed phantoms (i.e., resolution and contrast), and the resolution and contrast to noise ratio (CNR) were calculated. Results: The results of resolution phantom imaging without any beamforming showed that only bars with the value of 0.125 and 0.167 lp/mm were distinguishable, and the 0.1 bars were not recognizable in the imaging. In addition, increasing the number of transmitters led to no noticeable change in resolution for 0.125 and 0.167 lp/mm bars. In all beamforming techniques for imaging the contrast phantom, the CNR parameter up to an object with a diameter of 8 mm increases with increasing diameter without any change. Conclusion: The beamforming technique using three simultaneous transmitters improved the resolution by about 1 mm compared to the normal strategy. In addition to high-contrast images, beamforming with 9 simultaneous transmitters led to a preferable technique.

15.
Ultrasonics ; 126: 106808, 2022 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-35921724

RESUMEN

This paper presents an adaptive subarray coherence-based post-filter (ASCBP) applied to the eigenspace-based forward-backward minimum variance (ESB-FBMV) beamformer to simultaneously improve image quality and beamformer robustness. Additionally, the ASCBP can separate close targets. The ASCBP uses an adaptive noise power weight based on the concept of the beamformer's array gain (AG) to suppress the noise adaptively and achieve improved images. Moreover, a square neighborhood average was applied to the ASCBP in order to provide more smoothed square neighborhood ASCBP (SN-ASCBP) values and improve the speckle quality. Through simulations of point phantoms and cyst phantoms and experimental validation, the performance of the proposed methods was compared to that of delay-and-sum (DAS), MV-based beamformers, and subarray coherence-based post-filter (SCBP). The simulated results demonstrated that the ASCBP method improved the full width at half maximum (FWHM) by 57 % and the coherent interference suppression power (CISP) by 52 dB compared to the SCBP post-filter. Considering the experimental results, the SN-ASCBP method presented the best enhancement in terms of generalized contrast to noise ratio (gCNR) and contrast ratio (CR) while the ASCBP showed the best improvement in FWHM among other methods. Furthermore, the proposed methods presented a striking performance in low SNRs. The results of evaluating the different methods under aberration and sound speed error illustrated the better robustness of the proposed methods in comparison with others.


Asunto(s)
Quistes , Procesamiento de Señales Asistido por Computador , Algoritmos , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Fantasmas de Imagen , Ultrasonografía/métodos
16.
Biomed Eng Online ; 21(1): 40, 2022 Jun 18.
Artículo en Inglés | MEDLINE | ID: mdl-35717330

RESUMEN

BACKGROUND: The minimum variance (MV) beamformer can significantly improve the image resolution in ultrasound imaging, but it has limited performance in noise reduction. We recently proposed the covariance matrix-based statistical beamforming (CMSB) for medical ultrasound imaging to reduce sidelobes and incoherent clutter. METHODS: In this paper, we aim to improve the imaging performance of the MV beamformer by introducing a new pixel-based adaptive weighting approach based on CMSB, which is named as covariance matrix-based adaptive weighting (CMSAW). The proposed CMSAW estimates the mean-to-standard-deviation ratio (MSR) of a modified covariance matrix reconstructed by adaptive spatial smoothing, rotary averaging, and diagonal reducing. Moreover, adaptive diagonal reducing based on the aperture coherence is introduced in CMSAW to enhance the performance in speckle preservation. RESULTS: The proposed CMSAW-weighted MV (CMSAW-MV) was validated through simulation, phantom experiments, and in vivo studies. The phantom experimental results show that CMSAW-MV obtains resolution improvement of 21.3% and simultaneously achieves average improvements of 96.4% and 71.8% in average contrast and generalized contrast-to-noise ratio (gCNR) for anechoic cyst, respectively, compared with MV. in vivo studies indicate that CMSAW-MV improves the noise reduction performance of MV beamformer. CONCLUSION: Simulation, experimental, and in vivo results all show that CMSAW-MV can improve resolution and suppress sidelobes and incoherent clutter and noise. These results demonstrate the effectiveness of CMSAW in improving the imaging performance of MV beamformer. Moreover, the proposed CMSAW with a computational complexity of [Formula: see text] has the potential to be implemented in real time using the graphics processing unit.


Asunto(s)
Algoritmos , Procesamiento de Señales Asistido por Computador , Simulación por Computador , Procesamiento de Imagen Asistido por Computador/métodos , Fantasmas de Imagen , Ultrasonografía/métodos
17.
Curr Med Imaging ; 18(9): 939-951, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35249498

RESUMEN

BACKGROUND: This paper presents an improved radar-based imaging system for breast cancer detection that features p-slot ultrawideband antennae in a 32-array set-up. The improved reconstruction algorithm incorporates the phase coherence factor (PCF) into the conventional delay and sum (DAS) beamforming algorithm, thus effectively suppressing noise arising from the side- and gratinglobe interferences. METHODS: The system is tested by using several breast models fabricated from chemical mixtures formulated on the basis of realistic human tissues. Each model is placed in a hemispherical breast radome that was fabricated from polylactide material and surrounded by 32 p-slot antennae mounted in four concentric layers. These antennae are connected to an 8.5 GHz vector network analyser through two 16-channel multiplexers that automatically switch different combinations of transmitter and receiver pairs in a sequential manner. RESULTS: The system can accurately detect 5 mm tumours in a complex and homogeneously dense 3D breast model with an average signal-to-clutter ratio and full-width half-maximum of 7.0 dB and 2.3 mm, respectively. These values are more competitive than the values of other beamforming algorithms, even with contrasts as low as 1:2. CONCLUSION: The proposed PCF-weighted DAS is the best-performing algorithm amongst the tested beamforming techniques. This research paves the way for a clinical trial involving human subjects. Our laboratory is planning such a trial as part of future work.


Asunto(s)
Procesamiento de Imagen Asistido por Computador , Microondas , Algoritmos , Humanos , Procesamiento de Imagen Asistido por Computador/métodos , Imagenología Tridimensional , Fantasmas de Imagen
18.
Med Phys ; 48(11): 7410-7426, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34529281

RESUMEN

PURPOSE: Thermal dose delivery in microwave hyperthermia for cancer treatment is expected to benefit from the introduction of ultra-wideband (UWB)-phased array applicators. A full exploitation of the combination of different frequencies to improve the deposition pattern is, however, a nontrivial problem. It is unclear whether the cost functions used for hyperthermia treatment planning (HTP) optimization in the single-frequency setting can be meaningfully extended to the UWB case. METHOD: We discuss the ability of the eigenvalue (EV) and a novel implementation of iterative-EV (i-EV) beam-forming methods to fully exploit the available frequency spectrum when a discrete set of simultaneous operating frequencies is available for treatment. We show that the quadratic power deposition ratio solved by the methods can be maximized by only one frequency in the set, therefore rendering EV inadequate for UWB treatment planning. We further investigate whether this represents a limitation in two realistic test cases, comparing the thermal distributions resulting from EV and i-EV to those obtained by optimizing for other nonlinear cost functions that allow for multi-frequency. RESULTS: The classical EV-based single-frequency HTP yields systematically lower target SAR deposition and temperature values than nonlinear HTP. In a larynx target, the proposed single-frequency i-EV scheme is able to compensate for this and reach temperatures comparable to those given by global nonlinear optimization. In a meninges target, the multi-frequency setting outperforms the single-frequency one, achieving better target coverage and 0 . 5 ∘ C higher T 90 in the tumor than single-frequency-based HTP. CONCLUSIONS: Classical EV performs poorly in terms of resulting target temperatures. The proposed single-frequency i-EV scheme can be a viable option depending on the patient and tumor to be treated, as long as the proper operating frequency can be selected across a UWB range. Multi-frequency HTP can bring a considerable benefit in regions typically difficult to treat such as the brain.


Asunto(s)
Hipertermia Inducida , Neoplasias , Algoritmos , Humanos , Hipertermia , Microondas , Neoplasias/terapia
19.
Sensors (Basel) ; 21(13)2021 Jun 22.
Artículo en Inglés | MEDLINE | ID: mdl-34206337

RESUMEN

This paper presents a low-cost architecture that allows for beamforming with antenna arrays installed onto unmanned aerial vehicles (UAVs). Beam switching is proposed to improve the antenna gain towards the ground station with two three-element arrays installed below the wings of the UAV. The electromagnetic modeling of the complete structure (UAV and integrated antennas) was performed with commercial electromagnetic simulator Ansys HFSS. The radiation patterns were synthesized with particle swarm optimization (PSO). By employing lumped surface-mount device (SMD) components and switches, the design of the feeder to deliver proper excitation coefficients to the antennas is presented, and its performance was assessed by simulations. The proposed approach is demonstrated to be very effective with low-cost production.

20.
Clin Neurophysiol ; 132(9): 2136-2145, 2021 09.
Artículo en Inglés | MEDLINE | ID: mdl-34284249

RESUMEN

OBJECTIVE: To assess the feasibility of automatically detecting high frequency oscillations (HFOs) in magnetoencephalography (MEG) recordings in a group of ten paediatric epilepsy surgery patients who had undergone intracranial electroencephalography (iEEG). METHODS: A beamforming source-analysis method was used to construct virtual sensors and an automatic algorithm was applied to detect HFOs (80-250 Hz). We evaluated the concordance of MEG findings with the sources of iEEG HFOs, the clinically defined seizure onset zone (SOZ), the location of resected brain structures, and with post-operative outcome. RESULTS: In 8/9 patients there was good concordance between the sources of MEG HFOs and iEEG HFOs and the SOZ. Significantly more HFOs were detected in iEEG relative to MEG t(71) = 2.85, p < .05. There was good concordance between sources of MEG HFOs and the resected area in patients with good and poor outcome, however HFOs were also detected outside of the resected area in patients with poor outcome. CONCLUSION: Our findings demonstrate the feasibility of automatically detecting HFOs non-invasively in MEG recordings in paediatric patients, and confirm compatibility of results with invasive recordings. SIGNIFICANCE: This approach provides support for the non-invasive detection of HFOs to aid surgical planning and potentially reduce the need for invasive monitoring, which is pertinent to paediatric patients.


Asunto(s)
Epilepsia Refractaria/fisiopatología , Epilepsia Refractaria/cirugía , Electrocorticografía/métodos , Electrocorticografía/normas , Electrodos Implantados/normas , Magnetoencefalografía/métodos , Adolescente , Niño , Epilepsia Refractaria/diagnóstico , Electrocorticografía/instrumentación , Femenino , Estudios de Seguimiento , Humanos , Masculino , Reproducibilidad de los Resultados
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