RESUMEN
We report the detailed gross, histopathological and immunohistochemical study of Strobilocercus fasciolaris infection, the metacestodal stage of Taenia taeniaeformis, in the liver of laboratory Wistar rats. Necropsy examination of seventeen rats revealed transparent or white or cream to clear, thick walled cysts, 1 to 97 in number, measuring about 2mm to 12mm on one or many of the liver lobes and containing strobilocercus of Taenia taeniaeformis. Histopathological examination revealed the presence of the cross-section of larva surrounded by a thick fibrous capsule and moderate infiltration of lymphocytes, plasma cells and a few eosinophils. Fatty degeneration of hepatocytes, gastric mucosal hyperplasia, distended gastric glands and marked increase in the mucosal epithelial cells and goblet cells in the duodenum were also observed. Contamination of feed and bedding materials seems to be the probable source in these naturally infected rats.
Asunto(s)
Ciencia de los Animales de Laboratorio , Hepatopatías/veterinaria , Enfermedades de los Roedores/parasitología , Taenia/clasificación , Teniasis/veterinaria , Animales , Duodeno/patología , Fibrosarcoma/parasitología , Fibrosarcoma/patología , Fibrosarcoma/veterinaria , Inmunohistoquímica , India/epidemiología , Hígado/parasitología , Hígado/patología , Hepatopatías/parasitología , Hepatopatías/patología , Neoplasias Hepáticas/parasitología , Neoplasias Hepáticas/patología , Neoplasias Hepáticas/veterinaria , Ratas , Ratas Wistar , Enfermedades de los Roedores/epidemiología , Enfermedades de los Roedores/patología , Teniasis/epidemiología , Teniasis/parasitología , Teniasis/patologíaRESUMEN
Concurrent leishmaniasis and neoplasia has been reported in dogs. This study describes the presence of the protozoa within the cytoplasm of neoplastic cells in 3 different types of tumors. Leishmania amastigotes were detected by light and transmission electron microscopy and immunohistochemistry in a fibrosarcoma, a T-cell lymphoma, and an adrenocortical adenoma.
Asunto(s)
Adenoma Corticosuprarrenal/veterinaria , Enfermedades de los Perros/patología , Enfermedades de los Perros/parasitología , Fibrosarcoma/veterinaria , Leishmaniasis/veterinaria , Linfoma de Células T/veterinaria , Adenoma Corticosuprarrenal/parasitología , Adenoma Corticosuprarrenal/patología , Animales , Citoplasma/parasitología , Perros , Ensayo de Inmunoadsorción Enzimática/veterinaria , Femenino , Fibrosarcoma/parasitología , Fibrosarcoma/patología , Inmunohistoquímica/veterinaria , Leishmaniasis/patología , Linfoma de Células T/parasitología , Linfoma de Células T/patología , Masculino , Microscopía Electrónica de Transmisión/veterinariaRESUMEN
Tapeworm cysts were identified in liver of Wistar rats and it induced fibrosarcoma in liver and gastroenteropathy in stomach and intestine. The tapeworm larva was confirmed as Strobilocercus fasciolaris by PCR linked mitochondrial DNA sequencing. Light microscopy, special staining (masson trichrome) and immunoflouresence supported the diagnosis of fibrosarcoma. Infiltration of plasma cells, macrophages and eosinophils were observed in the liver section. Gastric mucosal hyperplasia, dilation of gastric glands with secretion, intestinal mucosal cell hyperplasia, proliferation of duodenal submucosal glands were confirmed by light microscopy and supported by PAS, AB staining. The concomitant development of hepatic sarcoma and gastroenteropathy by larvae of Taenia taeniaeformis (S. fasciolaris) infection is very rare and is the first reported case in Wistar rats to our knowledge.