Asunto(s)
Antiinfecciosos/sangre , Aceite de Coco/metabolismo , Recien Nacido Extremadamente Prematuro , Lauratos/sangre , Monoglicéridos/sangre , Nacimiento Prematuro , Administración Cutánea , Antiinfecciosos/administración & dosificación , Candida albicans/efectos de los fármacos , Candida albicans/crecimiento & desarrollo , Aceite de Coco/administración & dosificación , Femenino , Edad Gestacional , Humanos , Recién Nacido , Lauratos/administración & dosificación , Masculino , Monoglicéridos/administración & dosificación , Sepsis Neonatal/microbiología , Sepsis Neonatal/prevención & control , Ensayos Clínicos Controlados Aleatorios como Asunto , Staphylococcus aureus/efectos de los fármacos , Staphylococcus aureus/crecimiento & desarrollo , Staphylococcus epidermidis/efectos de los fármacos , Staphylococcus epidermidis/crecimiento & desarrolloRESUMEN
In the presence of a source of sulfane sulfur, a cyanolysis reaction catalyzed by serum albumin may contribute to cyanide detoxication. The active site for this catalysis by serum albumin has been investigated in competition studies with ligands that have known albumin binding sites. Despite complications caused by the occurrence of multiple primary and secondary sites for many ligands, the results show that the primary sites for bilirubin, steroids, indoles, aspirin, and palmitate are distinct from that for sulfur. Laurate is a tight-binding partial inhibitor of the cyanolysis reaction, competitive with cyanide rather than with sulfur. In view of the formal mechanism previously established for the catalyzed reaction, this result indicates that the sulfur-cyanolysis site is probably near the site occupied by laurate.