Monitoreo del impacto en la formación de especialistas en Medicina Intensiva y Emergencias en Matanzas / Monitoring the impact in the formation of specialist in intensive medicine and emergencies, Matanzas

Introducción: la evaluación y acreditación de la calidad en la formación de las especialidades médicas en Cuba, conceptualiza el monitoreo del impacto como el proceso dirigido a evaluar la correspondencia entre los objetivos del programa y los resultados alcanzados por sus participantes en el entorno social donde se desarrollan profesionalmente. Objetivo: aplicar la metodología diseñada para el monitoreo del impacto en la formación de las especialidades médicas en el Programa de Medicina Intensiva y Emergencias. Materiales y métodos: se realizó un estudio de corte pedagógico donde se aplicó la metodología diseñada en la Universidad de Ciencias Médicas de Matanzas, para monitorear el impacto en la formación de la especialidad de Medicina Intensiva y Emergencias, desarrollado en el Hospital Universitario Comandante Faustino Pérez Hernández. Participaron 6 egresados, 11 profesores, 8 tutores y 4 directivos de la última edición concluida (octubre de 2016 a noviembre de 2019). Resultados: se observó un alto impacto en la institución y mediano en el individuo, con contraste entre el diagnóstico inicial y durante la formación: de excelencia en el 100 % de los residentes, pero un diagnóstico final con 33,3 % excelente y 66,6 % bien. No se evaluó la etapa de transferencia o impacto en la sociedad, por el corto de tiempo de experiencia laboral de los egresados. Conclusiones:la metodología aplicada permitió conocer un mediano impacto en la formación de los egresados de Medicina Intensiva y Emergencias, por contrastación entre el diagnóstico inicial y durante la formación, de excelente con un diagnóstico final de bien (AU).

Introduction: the evaluation of the quality in the formation of the medical specialties in Cuba, conceptualize the monitored of the impact like the process directed to evaluate the correspondence among the objectives of the program and the results reached by their participants in the social environment where they are developed professionally, guaranteeing the relevancy of the program. Objective: to apply the methodology designed for the monitored of the impact in the formation of the medical specialties in the program of intensive Medicine and emergencies. Materials and methods: carried out a study of pedagogic court where the methodology was applied designed in the Medical University of Matanzas, for the monitored of the impact in the formation of the specialty of intensive Medicine and emergencies, developed in the university hospital "Faustino Pérez Hernández." They participated six graduate, four directives, 11 professors and tutors of the last concluded edition, from October of the 2016 to November of the one 2019. Results: a high impact was observed in the institution and medium in the individual, with a contrast among the initial diagnosis and during for formation of excellence in 100% of the residents, with a final diagnosis of 33,3% excellent and 66,6% well. It was not evaluated the transfer stage or impact in the society, for the short of time of labor experience of the graduate. Conclusions: the applied methodology allowed to know the medium impact in the formation of graduate in Intensive Medicine and Emergencies in Matanzas, for a contrast among the initial diagnosis and during the formation of excellent with the final diagnosis of well (AU).

Desarrollo histórico de la evaluación del impacto de la formación de especialidades médicas en Cuba / Develop historical of the evaluation of the impact in the formation of the medical specialties in Cuba

RESUMEN La evaluación en la formación surgió en el siglo XVII, buscando dar juicios de valor a las acciones y actitudes de los estudiantes, a la determinación sistemática del mérito, valor y significado del aspecto a evaluar en función de criterios y normas establecidas en aquella época. Su evolución desde lo conceptual y lo procesual tuvo la influencia de los paradigmas investigativos. Muchos han sido los modelos propuestos en el ámbito internacional para perfeccionar el proceso de evaluación de la calidad en la educación. Actualmente, se asocia el término "evaluación" con el término "impacto", usado con frecuencia como expresión del efecto de una acción determinada, con cambios o transformaciones generadas en las personas, organizaciones, procesos o productos. En Cuba, este proceso ha tenido diferentes etapas, pero no es hasta el siglo XXI que comienza a implementarse en el Sistema Universitario de Programas de Acreditación, actual Sistema de Evaluación y Acreditación de la Educación Superior, con el objetivo de lograr una mejora continua en la formación, acorde a los principios y exigencias de la sociedad socialista. Dentro del mismo, el Sistema de Evaluación y Acreditación de Especialidades de Posgrado desempeña un papel fundamental en el desarrollo de dicha figura del posgrado, teniendo una repercusión notable en el desarrollo de las ciencias médicas. Este artículo expone la evolución histórica de la evaluación de la calidad y su impacto en el proceso de formación de especialidades médicas en el país, como referente para futuras investigaciones (AU).

ABSTRACT Training assessment emerged in the 17 century, in search for giving value judgment to the students' actions and behavior, for systematic determining the worth, value and significance of the aspect to assess according to criteria and norms established at that time. Its evolution, from the point of view of the conceptual and process, received the influence of research paradigms. Many models have been proposed around the world to improve the process of quality assessing in the educational field. Currently, the term 'assessment' is associated to the term 'impact', frequently used as an expression of a determinate action's effect on changes or transformations in people, organizations, processes or products. This process has had different stages in Cuba, but only in the 21 century, the University System of Accreditation Programs (SUPRA by its acronym in Spanish) -currently known as Accreditation and Assessment System of High Education (SEAES by its acronym in Spanish)- has begun to be implemented, with the objective of achieving a better continuous training, according to the principles and demands of the socialist society. Among it, the Accreditation and Assessment System of Post-grade Specialties (SEA-EP by its acronym in Spanish), play an important role in the development of the post-grade figure, having a remarkable repercussion in the medical sciences. This article exposes the historical evolution of the quality assessment and its impact in the medical sciences training process in the country as a referent for subsequent researches (AU).

No Longer a Match: Trends in Radiation Oncology National Resident Matching Program (NRMP) Data from 2010-2020 and Comparison Across Specialties.

PURPOSE: To report trends in the number and types of applicants and matched trainees to radiation oncology in comparison to other specialties participating in the National Resident Matching Program (NRMP) between 2010 and 2020. METHODS AND MATERIALS: Data from the NRMP and Electronic Residency Application System (ERAS) were obtained for 18 medical specialties between 2010 and 2020. We assessed the numbers and types of applicants and matched trainees relative to available positions in the NRMP and Supplemental Offer and Acceptance Program (SOAP). RESULTS: In the 2020 NRMP, 122 US MD senior graduates preferentially ranked radiation oncology, a significant decrease from a median of 187 between 2010 to 2019 (interquartile range [IQR], 170-192; P < .001). Across all 18 specialties, radiation oncology experienced the greatest declines in the 2020 NRMP cycle relative to 2010 to 2019, in both the number of ERAS applicants from the United States and Canada (-31%) and the percentage of positions filled by US MD or DO senior graduates (-28%). Of 189 available positions, 81% (n = 154) filled in the NRMP prior to the SOAP, of which 65% (n = 122) were "matched" by US MD senior graduates who preferentially ranked radiation oncology as their top choice of specialty, representing a significant decrease from a median of 92% between 2010 to 2019 (IQR, 88%-94%; P = .002). The percentages of radiation oncology programs and positions unfilled in the NRMP prior to the SOAP were significantly increased in 2020 compared with 2010 to 2019 (programs: 29% vs 8% [IQR, 5%-8%; P < .001]; positions: 19% vs 4% [IQR, 2%-4%; P <.001]). Despite >99% (n = 127 of 128) of US MD or DO senior applicants preferring radiation oncology successfully matching to a radiation oncology position in the 2020 NRMP, 16 of 35 remaining unfilled positions were filled via the SOAP. Radiation oncology was the top user of the SOAP across all specialties participating in the 2020 NRMP, filling 15% of total positions versus a median of 0.9% (IQR, 0.3%-2.3%; P <.001). CONCLUSIONS: The supply of radiation oncology residency positions now far exceeds demand by graduating US medical students. Efforts to nullify a market correction revealed by medical student behavior via continued reliance on the SOAP to fill historical levels of training positions may not be in the best of interest of trainees, individual programs, or the specialty as a whole.

Mesenchymal Stem Cells Current Clinical Applications: A Systematic Review.

INTRODUCTION: Human Mesenchymal Stem Cells (hMSCs) are multipotent stem cells capable of renewing themselves and differentiation in vitro into different kinds of tissues. In vivo hMSCs are sources of trophic factors modulating the immune system and inducing intrinsic stem cells to repair damaged tissues. Currently, there are multiple clinical trials (CT) using hMSCs for therapeutic purposes in a large number of clinical settings. MATERIAL AND METHODS: The search strategy on clinicaltrials.gov has focused on the key term "Mesenchymal Stem Cells", and the inclusion and exclusion criteria were separated into two stages. Stage 1, CT on phases 1-4: location, the field of application, phase, and status. For stage 2, CT that have published outcome results: field of application, treatment, intervention model, source, preparation methods, and results. RESULTS: By July 2020, there were a total of 1,138 registered CT. Most studies belong to either phase 2 (61.0%) or phase 1 (30.8%); most of them focused in the fields of traumatology, neurology, cardiology, and immunology. Only 18 clinical trials had published results: the most common source of isolation was bone marrow; the treatment varied from 1-200 M hMSCs; all of them have similar preparation methods; all of them have positive results with no serious adverse effects. CONCLUSIONS: There appears to be a broad potential for the clinical use of hMSCs with no reported serious adverse events. There are many trials in progress, their future results will help to explore the therapeutic potential of these promising cellular sources of medicinal signals.

Artificial intelligence in medicine: A matter of joy or concern?

Artificial Intelligence (AI), a concept which dates back to the 1950s, is increasingly being developed by many medical specialties, especially those based on imaging or surgery. While the cognitive component of AI is far superior to that of human intelligence, it lacks consciousness, feelings, intuition and adaptation to unexpected situations. Furthermore, fundamental questions arise with regard to data security, the impact on healthcare professions, and the distribution of roles between physicians and AI especially concerning consent to medical care and liability in the event of a therapeutic accident.

Trends in Representation of Female Applicants and Matriculants in Canadian Residency Programs Across Specialties, 1995 to 2019.

Importance: Disparities in representation between sexes have been shown at multiple career stages in medicine despite increasing representation in the overall physician workforce. Objective: To assess sex representation of applicants to the Canadian R-1 entry match for postgraduate training programs from 1995 to 2019, comparing distribution between different specialties as well as applied vs matched applicants. Design, Setting, and Participants: This cross-sectional analysis of aggregate data provided by the Canadian Resident Matching Service between 1995 and 2019 analyzed aggregate data for the Canadian R-1 residency match from 1995 through 2019. Exposures: Applicant sex as reported in the Canadian Resident Matching Service database. Main Outcomes and Measures: The sex representation of applicants was compared and the longitudinal trends in sex representation were analyzed by specialty between 1995 and 2019. The sex representation of overall applicants to the Canadian R-1 entry match were compared with matched applicants, and both were stratified by specialty. Results: A total of 48 424 applicants were identified (26 407 [54.5%] female applicants), of which 41 037 were matched applicants. Using specialty groupings, female applicants were most highly represented in obstetrics and gynecology (1776 of 2090 [85.0%]) and least represented in radiology (658 of 2055 [32.0%]). Within individual subspecialties, female applicants had the lowest representation in neurosurgery (90 of 394 [22.8%]). While female applicants represented an increasing proportion of the overall applicant population between 1995 and 2019 (z = 2.71; P = .007), significant increases were seen in some, but not all, individual specialties. Differences by sex were found among Canadian medical graduate match rates to their top-ranked specialty: female applicants had a lower likelihood of being rejected for family medicine (rejection of male applicants: OR, 0.46; 95% CI, 0.39-0.54; P < .001) and psychiatry (OR, 0.59; 95% CI, 0.46-0.76; P < .001) and were more likely to be rejected for all-encompassing surgery (acceptance of male applicants: OR, 1.19; 95% CI, 1.10-1.28; P < .001). Conclusions and Relevance: Increasing representation of female residency applicants over time was seen in some, but not all, medical specialties in Canada, and sex-based differences in successful match rates were observed in some specialties. The reasons for these disparities require further investigation for corrective strategies to be identified.

LifeTime and improving European healthcare through cell-based interceptive medicine.

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

Structuring Mentoring in Medicine and Surgery. A Systematic Scoping Review of Mentoring Programs Between 2000 and 2019.

INTRODUCTION: Evidence of novice mentoring's successes in having senior clinicians support junior doctors and/or medical students in their clinical, academic, and research goals has spurred efforts to include mentoring in the core medical curriculum. However, lack of effective structuring threatens the viability of mentoring programs, precipitating ethical concerns about mentoring. This review aims to answer the question "what is known about mentoring structures in novice mentoring among medical students and junior doctors in medicine and surgery postings?," which will guide the design of a consistent structure to novice mentoring. METHODS: Levac (2010)'s framework was used to guide this systematic scoping review of mentoring programs in medicine and surgery published between 1 January 2000 and 31 December 2019 in PubMed, ScienceDirect, ERIC, Embase, Scopus, Mednar, and OpenGrey. A "split approach" involving concurrent independent use of a directed content analysis and thematic approach was used to analyze included articles. RESULTS: Three thousand three hundred ninety-five abstracts were identified. There was concordance between the 3 themes and categories identified in analyzing the 71 included articles. These were the host organization, mentoring stages, and evaluations. CONCLUSION: The data reveal the need for balance between ensuring consistency and flexibility to meet the individual needs of stakeholders throughout the stages of the mentoring process. The Generic Mentoring Framework provides a structured approach to "balancing" flexibility and consistency in mentoring processes. The Generic Mentoring Framework is reliant upon appropriate, holistic, and longitudinal assessments of the mentoring process to guide adaptations to mentoring processes and ensure effective support and oversight of the program.

Metal complexes in medicine and pharmacy - the past and the present III.

Bioactive metal complexes represent a promising and rapidly evolving area of pharmacotherapy. After the first part of our survey on metallopharmaceuticals dealing with antimicrobial activity of metal complexes and their application in diagnostics and the second part dedicated to anticancer properties of these compounds, this third and last part of the review focuses on several other applications of metals in therapy (mainly on the therapy of rheumatoid arthritis, some mental diseases, diabetes, as well as on chelation therapy). Following a brief account of the historical development of clinical use of the respective category of drugs, their chemical properties, toxicity, clinical applications and mechanism of action are discussed. The aim of this brief survey is to provide basic outline of the area of metallopharmacy, aimed at specialists in pharmacy and chemistry as well as at the general educated public.

Comportamiento del proceso de evaluación externa de las especialidades médicas en la Universidad de Matanzas / Behavior of the external evaluation process of medical specialties at the University of Matanzas

RESUMEN Introducción: la acreditación en las especialidades de posgrado es la expresión de la calidad de un programa educativo. Establece entre sus procedimientos la autoevaluación de los propios ejecutores del programa y la evaluación externa, con vistas a la acreditación. Objetivo: describir según el patrón de calidad de El Sistema de Evaluación y Acreditación de las Especialidades de Posgrado, el comportamiento del proceso de evaluación externa para la acreditación de las especialidades médicas en la Universidad de Ciencias Médicas de Matanzas, en el 2018-2019. Materiales y métodos: se realizó un estudio de carácter exploratorio descriptivo, predominantemente cualitativo para describir el comportamiento de la evaluación externa de los programas de Formación de las Especialidades Médicas en la Universidad de Ciencias Médicas de Matanzas. Se aplicaron métodos teóricos como el análitico-sintético, inductivo-deductivo e histórico-lógico; así como empíricos y el de revisión documental. Resultados: se constató insuficiencias relacionadas con la obtención de grados científicos, bajo índice de publicaciones del claustro, insuficiente publicación de los resultados científicos de los estudiantes. Se evidenció que los indicadores evaluados se aproximan a los estándares establecidos por la metodología empleada. Conclusiones: durante el proceso de autoevaluación se identificaron fortalezas y debilidades de la universidad, para enfrentar el proceso de acreditación de las especialidades de posgrado. La elaboración del plan de mejora y su control suelen ser las vías idóneas para asegurar la gestión de la calidad y el resultado final obtenido (AU).

ABSTRACT Introduction: the accreditation of postgraduate specialties is the expression of quality of an educative program. Among its procedures, it establishes the auto-evaluation by the proper program executors and the external evaluation with a view to accreditation. Objective: to describe, according to the quality pattern on The System of Evaluation and Accreditation of Postgraduate Specialties, the behavior of the external evaluation process for the accreditation of medical specialties in the University of Medical Sciences of Matanzas, in 2018-2019. Materials and methods: a descriptive exploratory, predominantly qualitative study to describe the behavior of the external evaluation of the programs of Training Medical Specialties in the University of Medical Sciences of Matanzas. The used theoretical methods were the analytic-synthetic one, the inductive-deductive, and the historical-logical; empiric methods and documental reviewing were also used. Results: Insufficiencies were found related to obtaining scientific degrees, low publication rates of the training staff and poor publication of the students' scientific results. It was evidenced that the evaluated indicators were close to the standards set up for the used methodology. Conclusions: several strengths and weaknesses of the university to affront the accreditation process of the postgraduate specialties were found during the process of auto evaluation. The elaboration of the improvement plan and its control are usually the suitable ways to achieve the quality management and the final result (AU).

Practical implications of the 2019 Nobel Prize in Physiology or Medicine: from molecular adaptation to hypoxia to novel anti-anemic drugs in the clinic.

The 2019 Nobel Prize for Medicine or Physiology was assigned to three prestigious physician-scientists, Gregg L. Semenza, William G. Kaelin, and Peter J. Ratcliffe, who clarified the molecular mechanisms of hypoxia adaptation. This viewpoint traces their fundamental findings, which have paved the way for the development of innovative drugs for a wide range of common diseases, including cancer and anemia.

[Hegemonic medical model: Possible trends, and more or less imaginary trends]. / Modelo médico hegemónico: tendencias posibles y tendencias más o menos imaginarias.

The purpose of this article is to analyze the possibilities that the hegemonic medical model will continue to prevail in the future or if significant changes will take place. The discussion will take as a starting point the characteristics and current functions of the hegemonic medical model, and reexamine them through a look at advancements in artificial intelligence, genetic research, and robotics in health-illness-care-prevention processes. The analysis takes on issues such as possible increases in life expectancy, what is needed to "cure old age," as well as processes that are modifying the doctor-patient relationship. It is concluded that although significant changes are taking place, the characteristics and functions of the hegemonic medical model remain unmoved.

El objetivo de este texto es analizar la posibilidad futura de que el modelo médico hegemónico siga perpetuándose o se generen cambios significativos. Para ello, se parte de las características y funciones actuales del modelo médico hegemónico y se las observa a través de algunos de los aportes de la inteligencia artificial, de las investigaciones genéticas y de la robótica, referidas a procesos de salud-enfermedad-atención-prevención, entre los que se analizan las posibilidades de fuertes incrementos en la esperanza de vida, las necesidades de "curar la senectud", así como los procesos que están modificando la relación médico-paciente, llegando a la conclusión de que si bien se observan algunas modificaciones sustantivas, las características y funciones del modelo médico hegemónico siguen siendo las mismas.

XIth EPR Workshop on Applications of EPR in Biology and Medicine.

We are pleased and honored to present this special issue for CBBI on the broad topic of biomedical EPR. The papers herein resulted from the most recent October 2019 EPR Workshop in Kraków that encompasses work from outstanding researchers in the field. Before describing the range of articles, we have briefly summarized the history of these workshops and the publications that resulted.

The potential for use of non-thermal plasma in microbiology and medicine.

The overview provides basic information on non-thermal plasma, its properties, and methods of its generation. It gives examples of its use in the inactivation of bacteria including biofilms, fungi, and prions. Related applications in human medicine, namely in wound healing, antitumor therapy, dental medicine, and dermatomycosis therapy are also mentioned.

Exercise medicine in cancer care.

BACKGROUND: Every four minutes, an Australian is diagnosed with cancer. Early detection and effective treatment means that many of these people are living with the side effects of cancer and its treatment for numerous years. OBJECTIVE: The aim of this article is to summarise the evidence examining the role of exercise in cancer care. DISCUSSION: Exercise is a safe and effective adjunct therapy in cancer care. Patients with cancer who regularly engage in moderate-intensity exercise are more likely to have: fewer and less severe treatment-related side effects; a lower relative risk of developing other chronic diseases; and, in some cases, a lower relative risk of cancer recurrence and mortality. Available evidence highlights the benefits of general practitioners (GPs) discussing and recommending exercise to their patients with cancer. To optimise the therapeutic effect of exercise, GPs may consider referring patients with cancer to an exercise physiologist or physiotherapist who has experience in cancer care.

Implementation of artificial intelligence in medicine: Status analysis and development suggestions.

The general public's attitudes, demands, and expectations regarding medical AI could provide guidance for the future development of medical AI to satisfy the increasing needs of doctors and patients. The objective of this study is to investigate public perceptions, receptivity, and demands regarding the implementation of medical AI. An online questionnaire was designed to investigate the perceptions, receptivity, and demands of general public regarding medical AI between October 13 and October 30, 2018. The distributions of the current achievements, public perceptions, receptivity, and demands among individuals in different lines of work (i.e., healthcare vs non-healthcare) and different age groups were assessed by performing descriptive statistics. The factors associated with public receptivity of medical AI were assessed using a linear regression model. In total, 2,780 participants from 22 provinces were enrolled. Healthcare workers accounted for 54.3 % of all participants. There was no significant difference between the healthcare workers and non-healthcare workers in the high proportion (99 %) of participants expressing acceptance of AI (p = 0.8568), but remarkable distributional differences were observed in demands (p < 0.001 for both demands for AI assistance and the desire for AI improvements) and perceptions (p < 0.001 for safety, validity, trust, and expectations). High levels of receptivity (approximately 100 %), demands (approximately 80 %), and expectations (100 %) were expressed among different age groups. The receptivity of medical AI among the non-healthcare workers was associated with gender, educational qualifications, and demands and perceptions of AI. There was a very large gap between current availability of and public demands for intelligence services (p < 0.001). More than 90 % of healthcare workers expressed a willingness to devote time to learning about AI and participating in AI research. The public exhibits a high level of receptivity regarding the implementation of medical AI. To date, the achievements have been rewarding, and further advancements are required to satisfy public demands. There is a strong demand for intelligent assistance in many medical areas, including imaging and pathology departments, outpatient services, and surgery. More contributions are imperative to facilitate integrated and advantageous implementation in medical AI.

Editorial: A New Bright Era for Evolutionary Medicine.

Evolutionary Medicine is a fast-growing research field providing biomedical scientists with valuable information on molecular and pathophysiological mechanisms of disease. Evolutionary theory explains many medical conditions and it can contribute to new innovative treatments. This is the reason that Journal of Molecular Evolution has devoted this issue to Evolutionary Medicine. Nine detailed review papers are included in this issue, analyzing topics that are among the "hottest" subjects of Evolutionary Medicine. All information is up to date and highly valuable for scientists that would like to start their career or get updated on this field.