RESUMEN
We describe the successful management of Anncaliia algerae microsporidial myositis in a man with graft versus host disease after hemopoietic stem cell transplantation. We also summarize clinical presentation and management approaches and discuss the importance of research into the acquisition of this infection and strategies for prevention.
Asunto(s)
Albendazol/uso terapéutico , Antiprotozoarios/uso terapéutico , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Microsporidios/aislamiento & purificación , Miositis/tratamiento farmacológico , Esporas Fúngicas/aislamiento & purificación , Anciano , Enfermedad Injerto contra Huésped/tratamiento farmacológico , Enfermedad Injerto contra Huésped/etiología , Enfermedad Injerto contra Huésped/inmunología , Enfermedad Injerto contra Huésped/patología , Humanos , Inmunosupresores/uso terapéutico , Masculino , Microsporidios/efectos de los fármacos , Microsporidios/patogenicidad , Miositis/diagnóstico , Miositis/inmunología , Miositis/microbiología , Nueva Gales del Sur , Esporas Fúngicas/efectos de los fármacos , Esporas Fúngicas/patogenicidad , Trasplante HomólogoRESUMEN
Members of the phylum Microspora are all obligate intracellular parasites. Little is known concerning metabolic pathways in these parasites, some of which pose serious problems in immunocompromised patients. We investigated polyamine metabolism in the systemic pathogen Enterocytozoon cuniculi using intact pre-emergent spores, and cell-free preparations. We found both polyamine synthetic and interconversion pathways to be operative, as evidenced by conversion of ornithine into polyamines, and production of spermidine from spermine by pre-emergent spores. Recent developments in the antitumour field have highlighted the ability of bis-ethylated polyamine analogues to reduce polyamine levels and block growth of tumour cells. In light of enhanced polyamine uptake in Enc. cuniculi, we have begun to study bis-aryl 3-7-3 and bis-ethyl oligoamine analogues as leads for chemotherapy of microsporidia.
Asunto(s)
Poliaminas Biogénicas/metabolismo , Microsporidios/efectos de los fármacos , Microsporidios/metabolismo , Animales , Antiprotozoarios/química , Antiprotozoarios/farmacología , Poliaminas Biogénicas/antagonistas & inhibidores , Poliaminas Biogénicas/biosíntesis , Enterocytozoon/efectos de los fármacos , Enterocytozoon/metabolismo , Humanos , Concentración 50 Inhibidora , Poliaminas/química , Poliaminas/farmacologíaRESUMEN
The first case of microspotidiosis in Central America is describes in en AIDS patient from Costa Rica. Electronic microscopy studies indicate that the spores were not included in a parasitophorous vacuole, but they are in direct contact with the cell cytoptasm. Sporogonic proliferative plasmodial forms presence and localization of the polar tubes in the anterior region of the spore, confirmed the specie Enterocytozoon bieneusi as the cause of this microsporidian infection