Asunto(s)
Seronegatividad para VIH/inmunología , Cefalea/inmunología , Enfermedad de Hodgkin/inmunología , Síndromes de Inmunodeficiencia/diagnóstico , Síndromes de Inmunodeficiencia/inmunología , Recuento de Leucocitos , Migraña con Aura/diagnóstico , Migraña con Aura/inmunología , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/inmunología , Trasplante de Células Madre , Tuberculosis del Sistema Nervioso Central/diagnóstico , Tuberculosis del Sistema Nervioso Central/inmunología , Adulto , Corteza Cerebral/patología , Diagnóstico Diferencial , Resultado Fatal , Enfermedad Injerto contra Huésped/diagnóstico , Enfermedad Injerto contra Huésped/inmunología , Enfermedad de Hodgkin/tratamiento farmacológico , Enfermedad de Hodgkin/radioterapia , Humanos , Imagen por Resonancia Magnética , Masculino , Sudáfrica/etnología , Reino UnidoRESUMEN
BACKGROUND/AIMS: Migraine headache is one of the most frequent types of headache in children in which multiple factors, including environmental and genetic, are involved. Celiac disease is an autoimmune-mediated disease with intolerance to gluten. The clinical spectrum of celiac disease is wide. Patients may present with malabsorption symptoms or extra-intestinal involvement, or can be totally asymptomatic. The association of migraine headache and celiac disease is not well known. The aim of this study was to assess the prevalence of celiac disease in children with migraine headache, in order to detect any relationship between them. METHODS: A total of 100 patients with migraine headache according to the International Headache Society criteria were enrolled in the study. 1500 children without history of headache or other medical diseases participating in another study for detection of the prevalence of celiac disease were selected in this study as a control group. Serum total IgA and anti-tissue transglutaminase IgA (anti-tTGA) antibodies were measured. In cases with positive serologic tests, duodenal biopsy was performed for confirmation of celiac disease. RESULTS: Two of 100 patients (2%) were found to have positive serologic tests for celiac disease, compared with 30 of 1500 children (2%) in the control group who had celiac disease. CONCLUSIONS: The results of this study showed that the prevalence of celiac disease was not higher in patients with migraine compared with the control group. Therefore, diagnostic tests for celiac disease are not necessary as a part of the management of migraine headache.
Asunto(s)
Enfermedad Celíaca/epidemiología , Migraña con Aura/epidemiología , Migraña sin Aura/epidemiología , Adolescente , Adulto , Enfermedad Celíaca/inmunología , Femenino , Humanos , Inmunoglobulina A/sangre , Masculino , Migraña con Aura/inmunología , Migraña sin Aura/inmunología , Prevalencia , Estudios Seroepidemiológicos , Transglutaminasas/inmunología , Adulto JovenRESUMEN
Migraine without aura (MO) and migraine with aura (MA) are disorders involving multiple environmental and genetic factors. The A/G polymorphism located within exon 1 of the gene encoding the cytotoxic T lymphocyte antigen 4 (CTLA-4) is associated with several HLA-associated multifactorial diseases. The CTLA-4 family shows a negative control on T-cell proliferation and cytokine production (TNF-alpha and IL-10). In the present study we investigated the contribution of the candidate gene CTLA-4 in migraine pathophysiology. Included in the study were 96 MO and 39 MA migraine patients and 106 healthy individuals as control group. The results showed no statistical difference of allele frequencies between patient group and control group. These results would indicate no association between MA and MO migraine and CTLA-4 polymorphism, excluding any possible role of the CTLA-4 gene as a genetic factor determining susceptibility to migraine.