Disruption of the left anterior ventrolateral temporal cortex along with the inferior longitudinal fasciculus impairs the ability to retrieve famous face names: Evidence from three longitudinal case studies.

The cortical distribution of the proper name (PN) retrieval network has been widely studied contrary to its connectional anatomy. Here, we report the case of three patients with a low-grade glioma damaging the mid-to-anterior part of the left temporal lobe. A longitudinal behavioural assessment showed that the surgery caused a long-lasting decline in PN retrieval performances in all patients. Furthermore, a detailed analysis of surgery-related structural disconnections revealed that interruption of the inferior longitudinal fasciculus was the unique common denominator.

Imputation of race and ethnicity categories using genetic ancestry from real-world genomic testing data.

The incompleteness of race and ethnicity information in real-world data (RWD) hampers its utility in promoting healthcare equity. This study introduces two methods-one heuristic and the other machine learning-based-to impute race and ethnicity from genetic ancestry using tumor profiling data. Analyzing de-identified data from over 100,000 cancer patients sequenced with the Tempus xT panel, we demonstrate that both methods outperform existing geolocation and surname-based methods, with the machine learning approach achieving high recall (range: 0.859-0.993) and precision (range: 0.932-0.981) across four mutually exclusive race and ethnicity categories. This work presents a novel pathway to enhance RWD utility in studying racial disparities in healthcare.

Notas sobre o pesquisar em cena(s) / Notes on researching in scenes / Notas sobre la investigación en escena(s)

O presente artigo tem como objetivo apresentar a construção metodológica desenvolvida em uma pesquisa de mestrado, na qual sustentamos a escrita de cenas como método de pesquisa da escuta clínica. As cenas do trabalho em questão foram recolhidas ao longo do tempo, no contorno da experiência de um projeto de extensão universitária de atenção à infância e adolescência em situação de vulnerabilidade social, situado em uma comunidade periférica. Apresentamos, neste texto, as interrogações que se elaboraram em torno da escolha pelo trabalho com cenas, e compartilhamos o resgate histórico dessas como um método de escrever a clínica, bem como a retomada de sua análise a partir da tradição psicanalítica. Amparadas nesta teoria e em leituras e contribuições do filósofo francês Jacques Derrida, embasamos a noção de que a cena se constitui como um lugar de produção, ao engendrar a configuração particular de elementos significantes nos processos de subjetivação e de construção social. A cena não é, então, compreendida aqui como uma representação do que acontece na clínica, mas como um modo de produzir a escuta e os seus processos de investigação.(AU)

This article aims to present the methodological construction developed in a master's research, in which the writing of scenes as a method of clinical listening research was endorsed. The scenes from the study in question were collected over time, from the experience gained in a project conducted within a university extension program on care in childhood and adolescence in social vulnerability, in a peripheral community. In this study, we present some questions that were elaborated surrounding the choices of working with scenes; and we share the historical rescue of this work as a method of writing on clinic practices and resuming their analysis from the psychoanalytic tradition. Based on the psychoanalytic theory and on the readings and contributions of the French philosopher Jacques Derrida, we corroborate the notion that the scene is constituted as a place of production, engendering the particular configuration of significant elements in the processes of subjectivation and social construction. Here, the scene is not a representation of clinical practice but one mode of producing listening and its research processes.(AU)

Este artículo tiene como objetivo presentar la construcción metodológica desarrollada en una investigación de maestría, en la que sostenemos la escritura de escenas como método de investigación de la escucha clínica. Las escenas del trabajo en cuestión se recogieron a lo largo del tiempo desde la experiencia en un proyecto de extensión universitario de atención a la niñez y adolescencia en situación de vulnerabilidad social aplicado en una comunidad periférica. En este texto, presentamos los interrogantes que se elaboraron en torno a la elección por el trabajo con escenas y compartimos el rescate histórico de las mismas como un método de escribir la clínica y la reanudación del análisis a partir de la tradición psicoanalítica. Amparadas en el psicoanálisis y en lecturas y contribuciones del filósofo francés Jacques Derrida, nos basaremos en la noción de que la escena se constituye como un lugar de producción, engendrando la configuración particular de elementos significantes en los procesos de subjetivación y de construcción social. La escena no es aquí una representación de lo que pasa en la clínica, sino un modo de producir escucha y sus procesos de investigación.(AU)

Etnia e nominação: ancestralidades em disputa e recomposições / Ethnicity and nomination: disputed ancestries and recompositions / Ethnicité et nomination: ascendances contestées et recompositions / Etnicidad y nominación: ascendencias en disputa y recomposiciones

O nome próprio, para além de designativo de uma identidade transmitida intergeracionalmente, pode abrigar memórias sociais consubstanciais às representações de uma genealogia familiar, entrecruzada a processos históricos transgeracionais. Neste estudo de caso, as ressonâncias de sentidos atrelados ao significante "Terena" são analisadas à luz do processo social onomástico de transformação de etnônimos em sobrenomes, com base em fundamentos teóricos e metodológicos etnopsicanalíticos. Encontrou-se não haver transparência nem correspondência linear, pelo menos neste caso, entre o significante Terena na qualidade de etnônimo e na condição de sobrenome familiar, ficando em aberto em que medida a sua multivocidade se prende ao recalque da memória familiar e/ou a resistências a uma identificação genealógica que em diferentes momentos históricos terá assumido valorações distintas e eventualmente antagônicas

The proper name, in addition to designating an identity transmitted intergenerationally, can harbor social memories consubstantial with the representations of a family genealogy, intertwined with transgenerational historical processes. In this case study, the resonances of meanings linked to the signifier "Terena" are analyzed in the light of the onomastic social process of transforming ethnonyms into surnames, based on ethnopsychoanalytic theoretical and methodological foundations. It was found that there was no transparency or linear correspondence, at least in this case, between the signifier Terena as an ethnonym and the same as a family surname, leaving open the extent to which its multivocality is linked to the repression of family memory and/or to resistance to a genealogical identification that at different historical moments will have assumed different and eventually antagonistic valuations

Le nom propre, en plus de désigner une identité transmise intergénérationnellement, peut abriter des mémoires sociales consubstantielles aux représentations d'une généalogie familiale, entremêlées de processus historiques transgénérationnels. Dans cette étude de cas, les résonances des significations liées au signifiant « Terena ¼ sont analysées à la lumière du processus social onomastique de transformation des ethnonymes en noms de famille, sur la base de fondements théoriques et méthodologiques ethnopsychanalytiques. Il a été constaté qu'il n'y avait pas de transparence ou de correspondance linéaire, du moins dans ce cas, entre le signifiant Terena en tant qu'ethnonyme et le même en tant que nom de famille, laissant ouverte la mesure dans laquelle sa multivocalité est liée au refoulement de la mémoire familiale et /ou à la résistance à une identification généalogique qui, à différents moments historiques, aura assumé des valorisations différentes et éventuellement antagonistes

El nombre propio, además de designar una identidad transmitida intergeneracionalmente, puede albergar memorias sociales consustanciales a las representaciones de una genealogía familiar, entrelazadas con procesos históricos transgeneracionales. En este estudio de caso se analizan las resonancias de significados vinculados al significante "Terena" a la luz del proceso social onomástico de transformación de etnónimos en apellidos, a partir de fundamentos teóricos y metodológicos etnopsicoanalíticos. Se constató que no existe transparencia ni correspondencia lineal, al menos en este caso, entre el significante Terena como etnónimo y el mismo como apellido familiar, dejando abierta la medida en que su multivocalidad está ligada a la represión de la memoria familiar y /oa la resistencia a una identificación genealógica que en diferentes momentos históricos habrá asumido valoraciones distintas y eventualmente antagónicas

A Collective Intelligence Platform to Support Older Cancer Survivors: Towards the Definition of LifeChamps System and Big Data Reference Architecture.

Within the most recent years, most of the cancer patients are older age, which implies the necessity to a better understanding of aging and cancer connection. This work presents the LifeChamps solution built on top of cutting-edge Big Data architecture and HPC infrastructure concepts. An innovative architecture was envisioned supported by the Big Data Value Reference Model and answering the system requirements from high to low level and from logical to physical perspective, following the "4+1 architectural model".

"Clara, esta sou eu!" Nome, acesso à saúde e sofrimento social entre pessoas transgênero / "Clara, that's me!" Name, access to health care and social suffering among transgender people / "¡Clara, esta soy yo!" Nombre, acceso a la salud y sufrimiento social entre personas transgénero

Esta pesquisa qualitativa objetivou compreender as relações entre acesso a serviços de saúde e experiências de sofrimento social entre pessoas trans. Foram conduzidas entrevistas semiestruturadas com cinco interlocutores e observações participantes. Os dados foram analisados por meio da codificação temática, originando duas categorias: "A negação do nome" e "Acesso à saúde e transfobia institucionalizada no Sistema Único de Saúde (SUS)". As narrativas das/os interlocutores permitiram localizar tais relações na sociogênese de experiências de sofrimento social. A negação do nome implica negação da humanidade da pessoa trans, bem como patologização de sua identidade e prejuízos no acesso à saúde, colocando a automedicação como uma possibilidade de agência. Concluiu-se que a transfobia institucionalizada no setor de saúde reproduz a precarização da cidadania de pessoas trans, destacando quanto a ação estatal com vistas a mitigar o sofrimento social pode, por vezes, intensificá-lo. (AU)

The aim of this qualitative study was to understand the relationships between access to health services and experiences of social suffering among trans people. We conducted semi-structured interviews with five participants and participant observation. The data were analyzed using thematic coding, giving rise to two categories: "Name denial" and "Access to health care and institutionalized transphobia in Brazilian National Health System". The participants' narratives allowed the researchers to situate these relationships within the sociogenesis of social suffering experiences. Name denial implies the negation of the humanity of trans people and pathologization of their identity, and compromises access to health care, making self-medication a possibility of agency. We conclude that institutionalized transphobia in the public health care system reproduces the precariousness of the citizenship of trans people, highlighting how government actions aimed at mitigating social suffering can sometimes intensify it. (AU)

Esta investigación cualitativa tuvo el objetivo de comprender las relaciones entre acceso a servicios de salud y experiencias de sufrimiento social entre personas trans. Se realizaron entrevistas semiestructuradas con cinco interlocutores y observaciones participantes. Los datos se analizaron por medio de la codificación temática originando dos categorías: "La negación del nombre" y "Acceso a la salud y transfobia institucionalizada en el Sistema Único de Salud". Las narrativas de los interlocutores permitieron localizar tales relaciones en la sociogénesis de experiencias de sufrimiento social. La negación del nombre implica la negación de la humanidad de la persona trans, así como la patologización de su identidad y prejuicios en el acceso a la salud, planteando la automedicación como una posibilidad de agencia. Se concluyó que la transfobia institucionalizada en el sector de la salud reproduce la precarización de la ciudadanía de personas trans, destacando hasta qué punto la acción estatal dirigida a mitigar el sufrimiento social puede, algunas veces, intensificarlo. (AU)

Online pathology request platform at the Semmelweis University / Online patológiai vizsgálatkéro felület létrehozása a Semmelweis Egyetemen.

Összefoglaló. Bevezetés: Az I. Patológiai és Kísérleti Rákkutató Intézet - a Semmelweis Egyetemen belüli diagnosztikai szolgáltatásnyújtás mellett - kiterjedt külso partneri hálózattal (vizsgálatmegrendelovel) bír. Az Intézet a napi muködése során párhuzamosan használja az egyetem központi informatikai rendszerét, valamint belso, folyamattámogató alkalmazását (workflow management). A külsos partnerek hozzáférése vizsgálatfeladásra az egyetemi központi informatikai rendszerhez nincs biztosítva. A vizsgálatok rendelése papíralapú, a minta érkeztetésekor a klinikai adatok rögzítése manuális, kifejezetten humáneroforrás-igényes. Célkituzés: Célunk volt a patológiai minták regisztrációjának egyszerusítése és felgyorsítása, az adminisztratív folyamatok hatékonyságának javítása. Módszer: A kituzött célt a minoségfejlesztésbol ismert Plan-Do-Check-Act (Tervezés-Cselekvés-Ellenorzés-Beavatkozás) ciklus módszereit alkalmazva kívántuk elérni, online, a mintavétel helyén elérheto, a meglévo belso folyamattámogató alkalmazáshoz kapcsolódó, szakterület-specifikus vizsgálatkéro felület kifejlesztésével. Eredmények: A vizsgálati minták regisztrációjának átlagos ideje 65%-kal csökkent az online vizsgálatkéro rendszerhez csatlakozott klinikai partnerek körében. Megbeszélés: Az elmúlt években tapasztalható volt, hogy kisebb, nem hatékonyan muködtetheto patológiai osztályok megszuntek, részben vagy egészben beolvadtak nagyobb diagnosztikai egységekbe. A humáneroforrás-problémák (elöregedo szakma a patológia) a fenti folyamatot minden bizonnyal tovább erosítik. Várható, hogy a nagyobb patológiai osztályokon a következo években a mintaszám tovább növekszik, a vizsgálatkérések egyre nagyobb hányada érkezik majd intézményen kívülrol. Következtetés: A patológiai informatika fejlesztésekor figyelembe kell venni, hogy szükséges már a mintavétel helyén biztosítani az informatikai támogatást a minta nyomon követéséhez, nem elégséges csak a laboron belüli folyamatok kiszolgálása. Orv Hetil. 2021; 162(49): 1962-1967. INTRODUCTION: The 1st Department of Pathology and Experimental Cancer Research, Semmelweis University (Budapest, Hungary) has a broad network of clinical partners, many of which are non-university hospitals. A separate hospital information system and a local laboratory workflow management system is used at the Department. University clinics use the hospital information system for electronic requesting of tests. Non-university partners have no access to the systems, requesting tests is paper-based, registration of the requests at the pathology lab is manual and laborious. OBJECTIVE: Our main objective was to improve the efficiency of the sample registration step of the pathology workflow. METHOD: Applying the Plan-Do-Check-Act procedure, a quality improvement project has been carried out and an online, subspecialty-based requesting application tool, interfaced with the current laboratory information system, was developed. RESULTS: The average sample registration time improved with 65% among the early user partners. DISCUSSION: The past years have shown smaller, inefficient pathology labs decreasing in number and integrated into larger regional diagnostic centers. Both issues of efficiency and quality assurance and problems rooted in human resources are drivers of further centralisation. The numbers of test requests and samples from non in-house partners are expected to be increased in the pathology labs in the future. CONCLUSION: Efficient and safe sample tracking has to start at the site of sample acquisition. State of the art laboratory information systems should support this expansion of competence. Orv Hetil. 2021; 162(49): 1962-1967.

What's in a Name? Implicit Bias Affects Patient Perception of Surgeon Skill.

BACKGROUND: Implicit bias is the unconscious associations and beliefs held toward specific demographic groups. Instagram is commonly used by plastic surgeons to market their practice. This study investigates whether a surgeon's name on a social media platform influences perception of their competence and their likelihood of gaining a new patient. METHODS: A mock Instagram post was created using before-and-after photographs of a breast augmentation patient. Eight different ethnicities were selected, and common female and male names were selected based on U.S. Census data for each ethnicity. Surveys using the Instagram post were distributed asking responders to evaluate the competency of the surgeon and how likely they are to become a patient of that plastic surgeon. The surgeon's name was the only variable in the survey. RESULTS: A total of 2965 survey responses were analyzed. The majority of responders were Caucasian (57 percent); 55 percent were men and 45 percent were women. Overall, competence and recruitment likelihood scores between surgeons of different ethnicities were not significantly different. Caucasian and Latinx responders both assigned higher competence and recruitment likelihood scores to their own respective ethnicities. CONCLUSIONS: Implicit bias plays a role in whether or not a patient is likely to seek care from a surgeon with an ethnically identifiable name. The two most common cosmetic surgery demographic groups, Caucasians and Latinxs, were also the only two ethnic groups to display in-group favoritism. Public education should be directed toward surgeon qualifications and experience in an effort to reduce implicit bias on patient decision-making.

MULTIMAP: Multilingual picture naming test for mapping eloquent areas during awake surgeries.

Picture naming tasks are currently the gold standard for identifying and preserving language-related areas during awake brain surgery. With multilingual populations increasing worldwide, patients frequently need to be tested in more than one language. There is still no reliable testing instrument, as the available batteries have been developed for specific languages. Heterogeneity in the selection criteria for stimuli leads to differences, for example, in the size, color, image quality, and even names associated with pictures, making direct cross-linguistic comparisons difficult. Here we present MULTIMAP, a new multilingual picture naming test for mapping eloquent areas during awake brain surgery. Recognizing that the distinction between nouns and verbs is necessary for detailed and precise language mapping, MULTIMAP consists of a database of 218 standardized color pictures representing both objects and actions. These images have been tested for name agreement with speakers of Spanish, Basque, Catalan, Italian, French, English, German, Mandarin Chinese, and Arabic, and have been controlled for relevant linguistic features in cross-language combinations. The MULTIMAP test for objects and verbs represents an alternative to the Oral Denomination 80 (DO 80) monolingual pictorial set currently used in language mapping, providing an open-source, standardized set of up-to-date pictures, where relevant linguistic variables across several languages have been taken into account in picture creation and selection.

Evaluating Bias in Speaker Introductions at the American Society for Radiation Oncology Annual Meeting.

PURPOSE: Introducing a physician without a professional title may reinforce bias in medicine by influencing perceived credibility. We evaluated differences in the use of professional titles in introductions of speakers at recent American Society for Radiation Oncology (ASTRO) Annual Meetings. METHODS AND MATERIALS: We reviewed recordings from the 2017 to 2019 ASTRO Annual Meetings and included complete introductions of speakers with a doctoral degree. Professional introduction was defined as "Doctor" or "Professor" followed by the speaker's full or last name. We collected use of professional introduction, introducer gender, speaker gender, and speaker professional and demographic variables. Identified speakers were sent surveys to collect self-reported demographic data. Analysis was performed using χ2 tests and multivariable logistic regression (MVA). RESULTS: Of 3267 presentations reviewed, 1226 (38%) met the inclusion criteria. Overall, 805 (66%) speakers and 710 (58%) introducers were men. Professional introductions were used in 74% (2017), 71% (2018), and 69% (2019) of the presentations. There was no difference in the use of professional introductions for male and female speakers (71% vs 73%; P = .550). On MVA, male introducers were associated with decreased use of professional address (odds ratio [OR], 0.36; 95% confidence interval [CI], 0.26-0.49; P < .001). At the 2019 conference, professional introduction was less likely to be used (2019 vs 2017: OR, 0.68; 95% CI, 0.49-0.96; P = 0.026). Those who self-identified as Asian/Pacific Islander were twice as likely to receive a professional introduction compared with those who identified as white (OR, 1.95; 95% CI, 1.07-3.64; P = .033). CONCLUSION: Male introducers were significantly less likely to introduce any speaker, regardless of gender, by their professional title, and overall use of professional introductions decreased from 2017 to 2019. Furthermore, no difference in professional introduction use by speaker gender was identified at the recent ASTRO meetings. Implementing speaker guidelines could increase the use of professional introductions and raise awareness of unconscious bias at future ASTRO meetings.