1.
Dermatol Surg
; 37(1): 116-8, 2011 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21091826
2.
Semin Diagn Pathol
; 25(4): 262-73, 2008 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19013892
RESUMO
The article reviews the main molecular pathology alterations of endometrial and ovarian carcinomas and melanoma. Several promising drugs targeting the genes most frequently altered in these tumors are under consideration. The most promising signaling pathways to be targeted for therapies in these tumors are the tyrosine kinase receptor (EGFR, HER2, c-KIT), the RAS/B-RAF/MAPK, the PI3K-mTOR, and apoptosis signaling pathways.