Expression of human epidermal growth factor receptor 2 in bladder urothelial carcinoma.

BACKGROUND: Urothelial bladder carcinoma (UBC) is one of the most prevalent cancers in men worldwide. Human epidermal growth factor receptor 2 (HER2) expression has been detected in a wide range of urothelial carcinoma. Despite many reports in the literature, the prognostic significance of this overexpression remains unclear. The aim of this study was to assess the expression of HER2 in urothelial bladder carcinomas and its association with clinical and pathological parameters. METHODS: 103 cases of UBC were diagnosed in our department between January 2014 and December 2015. The tumor specimens obtained by transurethral resection or cystectomy were evaluated by immunohistochemistry using HER2 antibody. RESULTS: HER2 protein overexpression was present in 11.7% of cases and associated with tumor grade (p = 0.003) and pathological stage (p = 0.015). In multivariate analysis, HER2 overexpression was associated only with tumor grade (P = 0.04). CONCLUSION: HER2 protein overexpression is noted in patients with high grade cancer. This expression may select patients for anti HER2 targeted therapy. Future larger and prospective studies will verify the frequency of HER2 alteration and the role of HER2 in the aggressive behavior.

Upper urinary tract lipoma: A case report.

Upper urinary tract (UUT) benign tumours are rare. We present a case of UUT lipoma in a 41-year-old man with left flank pain. A computed tomographic urography scan revealed an irregular thickening of the left renal collecting system wall extending from the upper calices to the renal pelvis. The diagnosis of UUT was made and the patient underwent a nephroureterectomy with bladder cuff excision, as standard treatment. However, macroscopic and histological examination revealed a lipomatous tumour with no sign of malignancy. To our knowledge this is the first reported case of its kind of a UUT managed first with a minimally invasive approach.

WITHDRAWN: Endorectal MRI accuracy in auguring tumour location, tumour extent, capsular perforation and seminal vesicle invasion of prostate cancer in north-African men.

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[Hydatid cyst of the kidney based on a series of 34 cases]. / Le kyste hydatique du rein. Traitement à propos de 34 cas.

AIM: Hydatid disease is endemic in some countries, where it constitutes a real public health problem. It can affect any, but the kidney is a relatively rare site, representing 2% to 4% of all visceral sites. Renal hydatid cyst only presents at the stage of complications. Laboratory tests may suggest the diagnosis, which is confirmed by radiology. Renal hydatid cyst raises therapeutic problems making conservative surgery difficult. The objective of this paper is the find the best adapted treatment. MATERIAL AND METHOD: 34 consecutive cases of renal hydatid cyst (1980-2001) were observed in 23 men and 11 women with a mean age of 42 years (range: 15-73 years). The clinical features were dominated by pain (63%), a mass (26%), hydaturia (11.4%), haematuria (31.4%), prolonged fever (23%) and hypertension (3%). Intravenous urography performed in all patients showed calcifications in 5 cases, a mass syndrome in 11 cases and silent kidney in 2 cases. Abdominal CT, performed in 8 patients, was necessary whenever the diagnosis remained uncertain, particularly in the case of pseudoneoplastic cysts. However, ultrasonography, performed in 30 patients, remains the preferred diagnostic examination. RESULTS: Treatment consisted of resection of the prominent dome in 23 cases, pericystectomy in 5 cases, 1 partial nephrectomy and 6 total nephrectomies. An associated procedure was performed during the same operation (hepatic, peritoneal hydatid cyst) in 3 cases, and was deferred (pulmonary hydatid cyst) in 1 case. The postoperative course was marked by urinary fistula in 2 cases and suppuration of the residual cavity in 1 case, treated by ultrasound-guided aspiration-drainage. CONCLUSION: The resection of the prominent dome is the most adapted treatment whenever possible.

[Genital Buschke Loewenstein tumors. Report of 4 cases]. / Tumeurs de Buschke Loewenstein à localisation génitale. A propos de quatre observations.

The authors present four cases of Buschke Loewenstein tumor. In three cases, the outcome was good despite areas of anaplasic change are seen in one of them. The outcome of the fourth patient was fatal because of multiples recurrences. Clinical features, diagnosis and treatment of this rare disease are discussed.

[Dermoid cyst of the testis]. / Le kyste dermoïde du testicule.

The authors report a case of a 30-year-old patient presenting with a right testicular mass. The presumptive diagnosis was that of a malignant tumour. The definitive diagnosis, confirmed by histological examination of the orchidectomy specimen, was that of a dermoid cyst. The aetiopathogenic, diagnostic and therapeutic characteristics of this exceptional disease are reported.