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Cerebellum ; 15(2): 213-32, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25823827

RESUMO

In the last few years, a lot of publications suggested that disabling cerebellar ataxias may develop through immune-mediated mechanisms. In this consensus paper, we discuss the clinical features of the main described immune-mediated cerebellar ataxias and address their presumed pathogenesis. Immune-mediated cerebellar ataxias include cerebellar ataxia associated with anti-GAD antibodies, the cerebellar type of Hashimoto's encephalopathy, primary autoimmune cerebellar ataxia, gluten ataxia, Miller Fisher syndrome, ataxia associated with systemic lupus erythematosus, and paraneoplastic cerebellar degeneration. Humoral mechanisms, cell-mediated immunity, inflammation, and vascular injuries contribute to the cerebellar deficits in immune-mediated cerebellar ataxias.


Assuntos
Ataxia Cerebelar/fisiopatologia , Cerebelo/fisiopatologia , Consenso , Encefalite/fisiopatologia , Doença de Hashimoto/fisiopatologia , Neuroimunomodulação/fisiologia , Animais , Ataxia Cerebelar/diagnóstico , Glutens/metabolismo , Humanos
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