[Delayed hypersensitivity to house dust-storage mites Thyrophagus putrescentiae in experimental allergic dermatoses]. / Zamedlennyi tip povyshennoi chuvstvitel'nosti k kleshcham ambarno-zernovogo kompleksa Tyrophagus putrescentiae v éksperimental'nykh allergodermatozakh.

House dust mites and storage mites proved to be one of the main allergens causing hypersensitivity in atopic dermatitis in allergic patients. The authors reproduced experimental allergic dermatosis on the model of delayed type hypersensitivity in guinea pigs, caused by sensitization to the allergen from the mite's bodies Tyrophagus putrescentiae--species having wide distribution in the country. The results characteristic for T-cell type hypersensitivity have been obtained: delayed positive skin tests after 24 hours, typical histomorphological picture (strong allergic alteration, epidermis desquamation, vasculitis, dermis T-cell infiltration and spongiosis--Waksman's syndrome). It is concluded that side by side with humoral IgE-mediated reaction there is strong delayed T-cell hypersensitivity to the storage mites Tyrophagus putrescentiae.

[Comparative study of the toxic, anaphylactoid, and sensitizing properties of 5-sulfo-8-mercaptoquinolinates of metals of the 8th and 3d groups of the periodic table]. / Sravnitel'noe issledovanie toksicheskikh, anafilaktoidnykh i sensibiliziruiushchikh svoistv 5-sul 'fo-8-merkap tokhinolinatov metallov VIII i III grupp periodicheskoi tablitsy.

Pronounced allergizing action of the compounds of group VIII metals of the periodic system, observed in occupational pathology and commencement of their wide clinical application as cancerostatic agents require a comprehensive study of the properties of these substances. Anaphylactoid, toxic and genuine sensitizing action of 5-sulfo-8-mercapto-quinolinates of group YIII metals and those of group III metals having similar properties was studied and compared with reference to 8 compounds. It was shown that histamine liberation from mast cells induced by these substances as well as inhibition of the respiration of mast cells depend on the central atom and electronic structure of the ligand. The mechanism of histamine liberation observed was similar to that of specific antigen and was related to the preservation of the respiratory processes, the system of microtubules and cell cyclic nucleotides. The compounds tested were also capable of sensitizing the animal in intracutaneous injection of the substance without exogenous carrier. Sensitization developed according to the reaction of both the immediate and delayed types.