Delayed Diagnosis of Acromegaly in the Context of Post-Traumatic Stress Disorder due to Symptoms Mimicking Known Psychotropic Medication Side Effects.

BACKGROUND: Acromegaly is caused by elevated secretion of human growth hormone, which is frequently because of intracranial tumors. This diagnosis is fairly uncommon with an incidence of 3 to 4 cases per million patients per year. We are presenting a case of acromegaly diagnosed in an active duty Chief Petty Officer. MATERIALS AND METHODS: A 38-year-old male Chief Petty Officer with no previous mental health diagnosis experienced post-traumatic stress disorder (PTSD)-like symptoms in early 2012 after deploying to Iraq and Afghanistan from 2010 to 2011. Initially he self-managed his symptoms, but in July 2012 he required a reduction mammoplasty because of gynecomastia. The metabolic workup revealed elevated prolactin, but this was not further investigated. His recovery from anesthesia was complicated by intensified PTSD-like symptoms, which continued to worsen after the surgery. On self-referral to mental health, he was diagnosed with PTSD and managed for 6 months with cognitive behavioral therapy. Because of persistent and worsening symptoms, his therapy was augmented to include continued cognitive behavioral therapy, alpha-blockers, antidepressants, antihistamines, and sleep aids. Because of night sweats, the selective serotonin reuptake inhibitors doses were modified. Night sweats persisted, and the patient was re-evaluated for other potential etiologies. On evaluation, the patient endorsed a history of obstructive sleep apnea, cervicalgia, visual changes, depressed mood, as well as multiple physical symptoms including coarsened facial features, large hands/feet, and increased interdental distance. On laboratory analysis, insulin-like growth factor 1 was noted to be 3 times the upper limit of normal, and a prolactin level was five times the upper limit of normal. A brain magnetic resonance imaging revealed a cystic pituitary lesion with suprasellar extension, compression of the infundibulum without invasion of the cavernous sinus, or displacement of the optic chiasm. Based on clinical history, physical examination, laboratory data, and the pituitary lesion, this patient was diagnosed with acromegaly. He was referred to neurosurgery for further evaluation and management. RESULTS AND CONCLUSION: This case shows that side effects of medications can easily mimic some medical conditions. The possibility of unrecognized disease should not be overlooked simply because a patient's symptoms that develop after starting a medication correspond well the side effect profile of the prescribed medications. This is especially true if side effects do not stop with alteration of medication dose, cessation of the medication, or changing to another medication. Pituitary adenomas are rare in patients treated for PTSD. However, attribution of PTSD patient's symptoms to the side effects of selective serotonin reuptake inhibitors therapy without considering a broader differential may lead to a missed diagnosis of an endocrine disease. In this case, the presence of an undiagnosed pituitary lesion resulted in ineffective medical management of PTSD in the patient. Mental health providers should remain allied with their primary care counterparts and consider directing patients to primary care for periodic physical re-evaluation to provide the most effective approach to symptom evaluation and management.

Magnetic Resonance Imaging Findings After Acute Patellar Dislocation in Children.

BACKGROUND: Acute patellar dislocation (APD) is a common knee injury in children. The pattern and frequency of injury to the medial patellofemoral ligament (MPFL) is different in pediatric compared with adult populations. PURPOSE: To report on injury patterns sustained to the MPFL after APD in children and to determine whether predisposing factors for APD cited in adults hold true in the pediatric population. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Magnetic resonance imaging (MRI) studies were reviewed for 36 children sustaining APD. Evidence of injury to the MPFL was documented, and when the MPFL was torn, the location of tear was determined. Presence of trochlear dysplasia, patella alta, tibial tubercle-trochlear groove (TTTG) distance, and thickness of the lateral patellofemoral retinaculum (LPR) were recorded and correlated with MPFL tear. RESULTS: Of the 36 patients sustaining APD, only 16 tore the MPFL. The location of MPFL tear was equally divided between the origin, the insertion, or both, with no case of midsubstance tear. There was a significant correlation identified between MPFL rupture and both LPR thickness greater than 3 mm and TTTG distance greater than 19 mm. CONCLUSION: The MPFL does not always tear in children who sustain APD, and the tear location is variable. A thickened LPR and increased TTTG distance predispose to MPFL tear.