Hearing Assessment After Total Annular Excision Tympanoplasty- Our Institutional Experience.

Objective: The objectives of this study were to record graft uptake, hearing status and any complication(s) after total annular excision (TAE) tympanoplasty and to compare them with previously operated underlay tympanoplasty patients. Design: Prospective study. Methods: Patients with chronic otitis media mucosal type aged between 15-45 years attending our outpatient department were assessed and eligible patients who gave consent for the study were included. Result: Patients of chronic otitis media mucosal type who underwent TAE tympanoplasty had 80% graft uptake. Post TAE tympanoplasty patients had good hearing assessed by tuning fork test and pure tone audiometry. Maximum improvement in hearing was seen at 500Hz frequency by pure tone audiometry in TAE tympanoplasty group. Histopathological examination of remnant tympanic membrane showed mucosalization. Conclusion: TAE tympanoplasty can effectively prevent development of granular myringitis. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-023-04083-8.

Treatment of deep-seated palatal vascular malformations by bleomycin sclerotherapy.

BACKGROUND: Vascular malformations of the head and neck are common. The management of these lesions is complex and challenging due to the high complication rate and recurrence following treatment. Palatal vascular malformations (PVMs) are infrequent and present as slow growing lesions in the palate with recurrent bleeding and pain. These lesions are best managed by sclerotherapy due to their posterior location and risk of bleeding if surgery is attempted. Many sclerosants have been used for treating PVMs but the use of intralesional bleomycin for these lesions has not been reported at length. This paper describes the use of intralesional bleomycin injections for the treatment of deep-seated palatal vascular malformations. METHODS: Intralesional bleomycin injections were given directly into the lesion with the patients under short general anaesthesia. The total dose of bleomycin ranged between 8 and 15 IU, which depends upon the body weight and was repeated every four weeks till the resolution of lesion was observed. RESULTS: All the lesions in 12 patients regressed significantly with serial bleomycin injections. Clinically, the involved palatal mucosa became normal and magnetic resonance imaging demonstrated the significant regression of the lesion in all the cases. No complications were encountered with the use of intralesional bleomycin. CONCLUSIONS: Intralesional bleomycin injections have proved to be an emerging modality in the management of remotely situated palatal vascular malformations. Their rapid regressive effect on the lesion coupled with a high safety margin makes bleomycin sclerotherapy the first choice of treatment for palatal vascular malformations.

Level of hyperlipidemia in blood donors: A correlative study in North Indian population.

BACKGROUND: Hyperlipidemia can be caused by abnormal elevation of lipids and lipoproteins in the blood. This increased can lead to heart disease. Risks which can be controlled include alcohol intake, physical activity, smoking, high blood pressure and genetic factors. Markers of increased cardiovascular risk appear to be lower in regular blood donor compared with single time donors as reflected by significantly lower total cholesterol and LDL levels. And it has been thought that there will be a direct relationship between lower risks of Heart diseases with repeated blood donation. AIM: The aim of the present study is to determine the effect of blood donation on single time and repeat donors by assessing their lipid levels and their family history of heart diseases. MATERIAL & METHODS: This cross-sectional study was carried out on (n = 80) random blood donors from the department of Transfusion Medicine KGMU. RESULTS: A significant correlation was found amongst hyperlipidemic level in single time donor & repeat donors and in donors with family history of heart diseases (p < 0.05). A positive association was found between hyperlipidemia with donor's weight (p < 0.05). CONCLUSION: Screening random donor platelets for hyperlipidemia and correlating the condition with other donor criteria like family history of heart diseases, types of donors, donors weight age and gender will help in making the patients safe as well as the donor deferral criteria more stringent to improve the quality of blood supply and will enable blood bankers to supply safe blood and improve the guidelines for blood safety.