RESUMO
BACKGROUND: Premature graying of hair as a risk marker among young smokers has a potential of identifying coronary artery disease (CAD) at a very early stage. There is absence of literature that assesses premature graying of hair as an independent marker of CAD in smokers. MATERIAL AND METHODS: The present single-centre case control study enrolled a total of 62 consecutive chronic smokers (≤ 45 years) (Group I) and 60 consecutive young CAD patients (≤45 years) who were chronic smokers (Group II). Another group comprising of 114 patients (≤45 years) having no smoking history and no cardiac ailments either (Group III) was enrolled as control population. All subjects were males. A detailed history and clinical examination regarding conventional coronary risk factors and carotid intima media thickness was done in both groups. RESULTS: The carotid intima media thickness, dyslipidemia and blood pressure were significantly higher in group I and II as compared to group III. When the groups were compared for graying of hair, it was found that the group II (i.e., smokers and CAD) had maximum prevalence of graying which was significantly higher than the control as well as smoker groups. The presence of premature graying of hair was associated with 3.24 times the risk of CAD on multiple logistic regression analysis. CONCLUSION: The presence of premature graying of hair was associated with an increased risk of CAD in young smokers. Premature graying of hair can be used as preliminary evidence by clinicians for classifying patients at risk for premature CAD especially in smokers.
Assuntos
Senilidade Prematura/complicações , Doença da Artéria Coronariana/etiologia , Cor de Cabelo/fisiologia , Fumar/efeitos adversos , Adulto , Senilidade Prematura/fisiopatologia , Pressão Sanguínea , Espessura Intima-Media Carotídea , Estudos de Casos e Controles , Doença da Artéria Coronariana/diagnóstico por imagem , Dislipidemias/complicações , Humanos , Modelos Logísticos , Masculino , Estudos Retrospectivos , Fatores de RiscoAssuntos
Hiperemia , Hipotensão , Pescoço/irrigação sanguínea , Veias/patologia , Adulto , Tamponamento Cardíaco/diagnóstico , Cardiomegalia/diagnóstico , Diagnóstico Diferencial , Eletrocardiografia , Feminino , Humanos , Hipopituitarismo/diagnóstico , Derrame Pericárdico/cirurgia , Radiografia TorácicaRESUMO
Acute lymphatic leukemia (ALL) was diagnosed in a pregnant patient after she presented with features of superior vena cava obstruction. Patient received chemotherapy during the course of pregnancy. A premature but normal female child was born. A brief review of literature with respect to the toxicity of cytostatic drugs to fetus and mother is made. Although adults with ALL frequently achieve a complete remission, the decision about conception and pregnancy need to be individualized because of unpredictable course.
Assuntos
Leucemia-Linfoma Linfoblástico de Células Precursoras/terapia , Complicações Neoplásicas na Gravidez/terapia , Adulto , Feminino , Humanos , GravidezRESUMO
Benign intracranial hypertension may occasionally be associated with various cranial nerve palsies. A case with multiple cranial nerve involvement is presented.