Is there a change in trend towards pyogenous spondylodiscitis compared to tubercular spondylodiscitis in India-A study of percutaneous biopsy evaluation in spondylodiscitis.

BACKGROUND: In Indian subcontinent where tuberculosis is endemic, the spinal infection was thought to be due to mycobacterium tuberculosis in most of the cases. Hence there is a practice of treating these patients with empirical antitubercular treatment. However, recent guidelines advice biopsy and tissue diagnosis before starting antibiotics. OBJECTIVE OF STUDY: Our retrospective study analyses the role of biopsy in establishing the microbiological diagnosis and thus identifying the incidence of pyogenic and tubercular spondylodiscitis presented to a tertiary care centre. MATERIALS AND METHODS: All patients who were diagnosed as spondylodiscitis by clinical and radiological criteria and who underwent biopsy were included in the study and data was retrieved from medical records and PACS. Criteria for tubercular spondylodiscitis included presence of mycobacterium tuberculosis either in smear/gene Xpert, or histopathological evidence of tuberculosis. Organism isolation other than MTB or absence of tubercular granuloma and response to antibiotics were considered as non-tubercular aetiology. RESULTS: Our study achieved 84% (n-63) accuracy for first biopsy and 34 patients (53.96%) were diagnosed as pyogenic spondylodiscitis. Organisms were isolated in 11 cases (32%) of pyogenic spondylodiscitis and tubercular bacilli in 17 cases (65%) of tubercular spondylodiscitis. Aspiration of pus yielded better isolation of organisms (P < 0.001) in pyogenic spondylodiscitis. 11% of cases showed drug resistant tuberculosis. CONCLUSION: We conclude that there is an increasing trend of pyogenous spondylodiscitis compared to tubercular spondylodiscitis in patients presenting to tertiary care centre, hence biopsy is essential to start antimicrobials.

Role of Percutaneous Image Guided Biopsy in Spinal Lesions: Adequacy and Correlation with MRI Findings.

INTRODUCTION: Although, MRI has increased our understanding of spinal pathologies, accurate diagnosis of spinal lesions need biopsy, so that early treatment can be initiated. AIM: To evaluate the accuracy of biopsy, safety and yield of percutaneously done image guided spinal biopsy using a large bore needle and correlate between MRI findings and biopsy as well as the importance of various MRI findings in establishing the diagnosis. MATERIALS AND METHODS: All spinal lesions after clinical and MRI evaluation were subjected to Jamshidi Needle biopsy using 11 gauge needles. Biopsy material was sent for culture/sensitivity, AFB smear and histopathological examination. The outcome assessment included percentage of patients in whom diagnosis was changed after biopsy, yield in biopsy and complications of biopsy. MRI findings, biopsy findings and final diagnosis were correlated to know the sensitivity and specificity of MRI and biopsy diagnosis. Logistic regression analysis was used to study the importance of each of MRI findings in making a diagnosis. RESULTS: Forty five patients with spinal lesions underwent biopsy using an 11 gauge Jamshidi needle. Initial biopsy was inconclusive in 4 patients giving a positive yield in about 91.2% of cases and a repeat biopsy ensured conclusive report in all cases. Following biopsy there was a change in diagnosis in 8% cases. MRI showed sensitivity of 85.71% and specificity of 93.54% for the diagnosis of malignancy and sensitivity of 85.71% and specificity of 86.48% for the diagnosis of tuberculosis. In contrast, initial biopsy had sensitivity of 92.85% and specificity of 100% for the diagnosis of malignancy and sensitivity of 71.42% and specificity of 100 % for the diagnosis of infection. Logistic regression analysis showed good correlation between malignancy and posterior bugle in the vertebral body in the absence of a fracture (p = 0.007), involvement of pedicles and posterior elements (p = 0.001) and soft tissue extension (p = 0.002); there was good correlation between infection and epidural abscess (p<0.001) as well as paradiscal involvement (p<0.001). CONCLUSION: Image guided biopsy done with good technique helps in accuracy of diagnosis thus ensuring the correct treatment at the earliest and has minimal complications. This study also shows that presence of epidural abscess and paradiscal involvement in MRI are highly suggestive of infection, while pedicle involvement and posterior bulge of vertebral body before the onset of pathological fracture are suggestive of malignancy, but all spinal lesions should be biopsied to confirm the diagnosis.

Difficulties in using Oswestry Disability Index in Indian patients and validity and reliability of translator-assisted Oswestry Disability Index.

BACKGROUND AND AIM OF THE STUDY: In Indian patients, in view of language plurality and illiteracy, self-reporting of English version of Oswestry Disability Index (ODI) is not practical. Our study aim was to find out to what extent self-reporting of ODI was possible and in cases where self-reporting was not possible, to see validity and reliability of a translator-assisted ODI score. MATERIALS AND METHODS: Fifty patients with low backache and who could not use the English version were assessed with ODI with the use of two translators at a gap of 3 h in a test and retest manner. Patients were also asked to report the most important disabling activity in their day-to-day life. RESULTS: A total of 58 questionnaires were filled during the study period out of which eight patients (14%) self-reported English version; while 50 patients needed a translator. The Cronbach's alpha between two translators for the ODI scores of 50 patients was 0.866, but aggregate of difference between two scores for each ODI component shows high difference between two translators for question nos. 3, 9, and 10. Cronbach's alpha was best when item no. 3 was deleted (0.875, translator 1; 0.777, translator 2). Thirty-seven people did not answer the question related to sexual activity. Agreement between two values was assessed using Kendall's tau and was found good (0.585, Spearman's coefficient 0.741). Kendall's tau values correlating total ODI score and individual components show that all the items move together, but correlation was poor for question no. 3 (P value 0.16 for translator 2). CONCLUSIONS: Translator-assisted ODI is a good outcome assessment tool in backache assessment in places where validated local language versions are not available, but in Indian patients, inclusion of question nos. 3 and 8 related to weight lifting and sexual function needs to be reviewed.